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Article Open Access

The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma

  • Authors:
    • Mingming Tang
    • Xinjiang Xu
    • Juanjuan Chen
    • Jiangfei Huang
    • Bin Jiang
    • Liang Han
  • View Affiliations / Copyright

    Affiliations: Department of Head and Neck Surgery, Nantong University Affiliated Tumor Hospital, Nantong, Jiangsu 226361, P.R. China, Department of Medicine, Nantong University Affiliated Tumor Hospital, Nantong, Jiangsu 226361, P.R. China, Department of Clinical Pathology, Nantong University Affiliated Hospital, Nantong, Jiangsu 226001, P.R. China
    Copyright: © Tang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3337-3342
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/ol.2017.6604
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Abstract

Growth-related gene product β (GROβ) is an angiogenic chemokine that belongs to the CXC chemokine family, and a number of studies have suggested that GROβ is associated with tumor development and progression. However, a number of studies have investigated the association between GROβ expression and the clinical attributes of laryngeal squamous cell carcinoma (LSCC). In the present study, one‑step quantitative polymerase chain reaction and immunohistochemistry analysis were used to detect GROβ expression and evaluate the association between its expression and the clinicopathological characteristics of LSCC. The results demonstrated that the GROβ mRNA and protein expression levels were significantly increased in LSCC compared with the corresponding non‑cancerous tissues. GROβ protein expression in LSCC was associated with tumor‑node‑metastasis stage, lymph node metastasis and histopathological grade. The Kaplan‑Meier method and Cox multi‑factor analysis indicated that high GROβ expression, lymph node metastasis and histopathological grade were significantly associated with poor survival of patients with LSCC. These data indicated that GROβ may be a novel prognostic biomarker of LSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Tang M, Xu X, Chen J, Huang J, Jiang B and Han L: The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma. Oncol Lett 14: 3337-3342, 2017.
APA
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., & Han, L. (2017). The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma. Oncology Letters, 14, 3337-3342. https://doi.org/10.3892/ol.2017.6604
MLA
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., Han, L."The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma". Oncology Letters 14.3 (2017): 3337-3342.
Chicago
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., Han, L."The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 3337-3342. https://doi.org/10.3892/ol.2017.6604
Copy and paste a formatted citation
x
Spandidos Publications style
Tang M, Xu X, Chen J, Huang J, Jiang B and Han L: The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma. Oncol Lett 14: 3337-3342, 2017.
APA
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., & Han, L. (2017). The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma. Oncology Letters, 14, 3337-3342. https://doi.org/10.3892/ol.2017.6604
MLA
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., Han, L."The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma". Oncology Letters 14.3 (2017): 3337-3342.
Chicago
Tang, M., Xu, X., Chen, J., Huang, J., Jiang, B., Han, L."The prognostic implications of growth-related gene product β in laryngeal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 3337-3342. https://doi.org/10.3892/ol.2017.6604
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