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Article Open Access

Characteristics of primary side population cervical cancer cells

Corrigendum in: /10.3892/ol.2025.15293
  • Authors:
    • Zhen‑Tong Wei
    • Xiao‑Wei Yu
    • Jia‑Xue He
    • Yan Liu
    • Song‑Ling Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecological Oncology, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Prenatal Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, Jilin 130021, P.R. China, Genetic Engineering Laboratory of The Chinese People's Liberation Army, Military Veterinary Institute, Acadamy of Military Medical Sciences, Changchun, Jilin 130122, P.R. China
    Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3536-3544
    |
    Published online on: July 18, 2017
       https://doi.org/10.3892/ol.2017.6606
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Abstract

The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence‑activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in vivo analysis of tumorigenicity were performed. The isolated SP cells accounted for ~4.73% of the total primary culture cells. The SP cells had a decreased prolife­ration rate and an increased distribution in G0/G1 compared with non‑SP (NSP) cells. Following isolation, SP cells exhibited increased proliferative and self‑renewal potency compared with NSP cells. Furthermore, significant ATP binding cassette subfamily G member 2 (ABCG2) expression was detected in SP cells but not in NSP cells. The tumor formation rate of SP cells was longer, and the tumor size and tumor formation rate of SP cells were increased in non‑obese diabetic/severe combined immunodeficiency mice. In conclusion, the present study demonstrated that SP cells can be isolated from primary cervical cancer cell culture, and SP cells are enriched with stem cell‑like cells that have a high capacity for colony formation and tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Wei ZT, Yu XW, He JX, Liu Y and Zhang SL: Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293. Oncol Lett 14: 3536-3544, 2017.
APA
Wei, Z., Yu, X., He, J., Liu, Y., & Zhang, S. (2017). Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293. Oncology Letters, 14, 3536-3544. https://doi.org/10.3892/ol.2017.6606
MLA
Wei, Z., Yu, X., He, J., Liu, Y., Zhang, S."Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293". Oncology Letters 14.3 (2017): 3536-3544.
Chicago
Wei, Z., Yu, X., He, J., Liu, Y., Zhang, S."Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293". Oncology Letters 14, no. 3 (2017): 3536-3544. https://doi.org/10.3892/ol.2017.6606
Copy and paste a formatted citation
x
Spandidos Publications style
Wei ZT, Yu XW, He JX, Liu Y and Zhang SL: Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293. Oncol Lett 14: 3536-3544, 2017.
APA
Wei, Z., Yu, X., He, J., Liu, Y., & Zhang, S. (2017). Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293. Oncology Letters, 14, 3536-3544. https://doi.org/10.3892/ol.2017.6606
MLA
Wei, Z., Yu, X., He, J., Liu, Y., Zhang, S."Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293". Oncology Letters 14.3 (2017): 3536-3544.
Chicago
Wei, Z., Yu, X., He, J., Liu, Y., Zhang, S."Characteristics of primary side population cervical cancer cells Corrigendum in /10.3892/ol.2025.15293". Oncology Letters 14, no. 3 (2017): 3536-3544. https://doi.org/10.3892/ol.2017.6606
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