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High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma

  • Authors:
    • Yu Qi
    • Ke Xin Cao
    • Fu Chen Xing
    • Chun Yang Zhang
    • Qi Huang
    • Kai Wu
    • Feng Biao Wen
    • Song Zhao
    • Xin Li
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of Oncology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3415-3420
    |
    Published online on: July 20, 2017
       https://doi.org/10.3892/ol.2017.6614
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Abstract

Melanoma-associated antigens (MAGEs) are a group of well-characterized members of the cancer/testis antigen family, which are expressed in a variety of malignant tumors. MAGE-A9, a subfamily of MAGE-As, has been studied in a number of types of cancer and have been associated with unfavorable survival outcome. However, the expression of MAGE-A9 in human esophageal squamous cell carcinoma (ESCC) and association of MAGE-A9 with the clinicopathological characteristics of ESCC, particularly prognostic characteristics, remains unknown. The present study aimed at determining the expression level of MAGE-A9 and at evaluating its clinical significance in human ESCC. Quantitative polymerase chain reaction (qPCR) and immunohistochemistry (IHC) analyses were performed to characterize the expression of MAGE-A9 in ESCC tissues. Kaplan-Meier estimator survival and Cox's regression analyses were used to evaluate the prognosis of 103 patients with ESCC. The results of qPCR and IHC analysis revealed that the expression of MAGE-A9 was significantly increased in ESCC tissues, compared with that in healthy tissues. Furthermore, the expression level of MAGE-A9 protein in ESCC was significantly associated with the pathological grade (P=0.008), tumor size (P=0.027) and lymph node metastasis (P=0.009). Multivariate analysis using Cox's regression model identified that the expression level of MAGE-A9 and lymph node metastasis were independent prognostic factors for the overall survival rate of patients with ESCC (P=0.006 and P=0.001, respectively). The results of the present study are, to the best of our knowledge, the first to indicate that MAGE-A9 expression is a valuable prognostic biomarker for ESCC and that it may serve as a targeted therapy in the treatment of ESCC. Increased expression of MAGE-A9 indicated an unfavorable survival outcome in patients with ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Qi Y, Cao KX, Xing FC, Zhang CY, Huang Q, Wu K, Wen FB, Zhao S and Li X: High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma. Oncol Lett 14: 3415-3420, 2017.
APA
Qi, Y., Cao, K.X., Xing, F.C., Zhang, C.Y., Huang, Q., Wu, K. ... Li, X. (2017). High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma. Oncology Letters, 14, 3415-3420. https://doi.org/10.3892/ol.2017.6614
MLA
Qi, Y., Cao, K. X., Xing, F. C., Zhang, C. Y., Huang, Q., Wu, K., Wen, F. B., Zhao, S., Li, X."High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma". Oncology Letters 14.3 (2017): 3415-3420.
Chicago
Qi, Y., Cao, K. X., Xing, F. C., Zhang, C. Y., Huang, Q., Wu, K., Wen, F. B., Zhao, S., Li, X."High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 3415-3420. https://doi.org/10.3892/ol.2017.6614
Copy and paste a formatted citation
x
Spandidos Publications style
Qi Y, Cao KX, Xing FC, Zhang CY, Huang Q, Wu K, Wen FB, Zhao S and Li X: High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma. Oncol Lett 14: 3415-3420, 2017.
APA
Qi, Y., Cao, K.X., Xing, F.C., Zhang, C.Y., Huang, Q., Wu, K. ... Li, X. (2017). High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma. Oncology Letters, 14, 3415-3420. https://doi.org/10.3892/ol.2017.6614
MLA
Qi, Y., Cao, K. X., Xing, F. C., Zhang, C. Y., Huang, Q., Wu, K., Wen, F. B., Zhao, S., Li, X."High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma". Oncology Letters 14.3 (2017): 3415-3420.
Chicago
Qi, Y., Cao, K. X., Xing, F. C., Zhang, C. Y., Huang, Q., Wu, K., Wen, F. B., Zhao, S., Li, X."High expression of MAGE-A9 is associated with unfavorable survival in esophageal squamous cell carcinoma". Oncology Letters 14, no. 3 (2017): 3415-3420. https://doi.org/10.3892/ol.2017.6614
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