Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2017 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer

  • Authors:
    • Xia Liu
    • Xiaogang Chen
    • Jiezuan Yang
    • Renyong Guo
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Laboratory Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 3787-3794
    |
    Published online on: July 20, 2017
       https://doi.org/10.3892/ol.2017.6619
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Coagulative and fibrinolytic disorders appear to be associated with the development of lung cancer. The aim of the present study was to determine plasma levels of von Willebrand factor (VWF) and a disintegrin and metalloproteinase with a thrombospondin type 1 motif 13 (ADAMTS‑13), and factor VIII (FVIII) activity, in association with O and non‑O blood groups in patients with lung cancer. Plasma levels of VWF and ADAMTS‑13, and FVIII activity were measured in 115 patients with lung cancer and 98 healthy subjects. Phenotyping of the ABO blood groups was also performed for the two groups. Significantly increased VWF levels and FVIII activity, as well as significantly decreased ADAMTS‑13 levels, were observed in patients with distant metastasis as compared with those without distant metastasis and the healthy controls. Plasma VWF levels and FVIII activity were significantly increased in subjects with non‑O type blood compared with those with type O blood in the two groups. However, a significant decrease in ADAMTS‑13 levels was observed only in the control group among those with non‑O type blood, compared with those with type O blood. The results of the present study indicate that increased VWF and decreased ADAMTS‑13 levels facilitate the invasiveness and metastasis of lung cancer. Non‑O blood groups constitute a risk factor for increased VWF and FVIII in plasma. Continued monitoring of VWF and ADAMTS‑13 levels, and of FVIII activity in patients with lung cancer with distinct blood groups may help to minimize the incidence of thrombotic events and improve assessment of disease progression.
View Figures

Figure 1

View References

1 

Gabazza EC, Taguchi O, Yamakami T, Machishi M, Ibata H and Suzuki S: Evaluating prethrombotic state in lung cancer using molecular markers. Chest. 103:196–200. 1993. View Article : Google Scholar : PubMed/NCBI

2 

Masago K, Fujita S, Mio T, Togashi Y, Kim YH, Hatachi Y, Fukuhara A, Irisa K, Sakamori Y and Mishima M: Clinical significance of the ratio between the alpha 2 plasmin inhibitor-plasmin complex and the thrombin-antithrombin complex in advanced non-small cell lung cancer. Med Oncol. 28:351–356. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Tas F, Kilic L, Serilmez M, Keskin S, Sen F and Duranyildiz D: Clinical and prognostic significance of coagulation assays in lung cancer. Respir Med. 107:451–457. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Terraube V, O'Donnell JS and Jenkins PV: Factor VIII and von Willebrand factor interaction: Biological, clinical and therapeutic importance. Haemophilia. 16:3–13. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Sporn LA, Marder VJ and Wagner DD: Inducible secretion of large, biologically potent von Willebrand factor multimers. Cell. 46:185–190. 1986. View Article : Google Scholar : PubMed/NCBI

6 

Sadler JE: Biochemistry and genetics of von Willebrand factor. Annu Rev Biochem. 67:395–424. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Fujikawa K, Suzuki H, McMullen B and Chung D: Purification of human von Willebrand factor-cleaving protease and its identification as a new member of the metalloproteinase family. Blood. 98:1662–1666. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Moake JL: Thrombotic microangiopathies. N Engl J Med. 347:589–600. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Franchini M, Favaloro EJ, Targher G and Lippi G: ABO blood group, hypercoagulability, and cardiovascular and cancer risk. Crit Rev Clin Lab Sci. 49:137–149. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Jenkins PV and O'Donnell JS: ABO blood group determines plasma von Willebrand factor levels: A biologic function after all? Transfusion. 46:1836–1844. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Sousa NC, Anicchino-Bizzacchi JM, Locatelli MF, Castro V and Barjas-Castro ML: The relationship between ABO groups and subgroups, factor VIII and von Willebrand factor. Haematologica. 92:236–239. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Terraube V, Marx I and Denis CV: Role of von Willebrand factor in tumor metastasis. Thromb Res. 120:(Suppl 2). S64–S70. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Martini F, Ferroni P, Guadagni F, Basili S, Spila A, D'Alessandro R, Mineo D, Laudisi A, Portarena I, Mariotti S, et al: Plasma von Willebrand factor antigen levels in non-small cell lung cancer patients. Anticancer Res. 25:403–407. 2005.PubMed/NCBI

14 

Brambilla E, Travis WD, Colby TV, Corrin B and Shimosato Y: The new World Health Organization classification of lung tumours. Eur Respir J. 18:1059–1068. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Bais R and Philcox M: Approved recommendation on IFCC methods for the measurement of catalytic concentration of enzymes. Part 8. IFCC method for lactate dehydrogenase (l-lactate: NAD+oxidoreductase, EC 1.1.1.27). International Federation of Clinical Chemistry (IFCC). Eur J Clin Chem Clin Biochem. 32:639–655. 1994.PubMed/NCBI

17 

Okuno T and Selenko V: Plasma fibrinogen determination by automated thrombin time. Am J Med Technol. 38:196–201. 1972.PubMed/NCBI

18 

Elf JL, Strandberg K and Svensson PJ: Performance of two relatively new quantitative D-dimer assays (Innovance D-dimer and AxSYM D-dimer) for the exclusion of deep vein thrombosis. Thromb Res. 124:701–705. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Barrowcliffe TW, Raut S, Sands D and Hubbard AR: Coagulation and chromogenic assays of factor VIII activity: General aspects, standardization, and recommendations. Semin Thromb Hemost. 28:247–256. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Goad KE and Gralnick HR: Coagulation disorders in cancer. Hematol Oncol Clin North Am. 10:457–484. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Guadagni F, Ferroni P, Basili S, Facciolo F, Carlini S, Crecco M, Martini F, Spila A, D'Alessandro R, Aloe S, et al: Correlation between tumor necrosis factor-alpha and D-dimer levels in non-small cell lung cancer patients. Lung Cancer. 44:303–310. 2004. View Article : Google Scholar : PubMed/NCBI

22 

Oleksowicz L, Bhagwati N and DeLeon-Fernandez M: Deficient activity of von Willebrand's factor-cleaving protease in patients with disseminated malignancies. Cancer Res. 59:2244–2250. 1999.PubMed/NCBI

23 

Unsal E, Atalay F, Atikcan S and Yilmaz A: Prognostic significance of hemostatic parameters in patients with lung cancer. Respir Med. 98:93–98. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Sugimoto Y, Watanabe M, Oh-Hara T, Sato S, Isoe T and Tsuruo T: Suppression of experimental lung colonization of a metastatic variant of murine colon adenocarcinoma 26 by a monoclonal antibody 8F11 inhibiting tumor cell-induced platelet aggregation. Cancer Res. 51:921–925. 1991.PubMed/NCBI

25 

Oleksowicz L, Bhagwati N, Fernandez MD, Seno R and Etkind P: Prognostic significance of platelet immunorelated GPIb expression in breast cancer. Cancer J Sci Am. 4:247–253. 1998.PubMed/NCBI

26 

León-Atance P, Moreno-Mata N, González-Aragoneses F, Cañizares-Carretero MÁ, Poblet-Martínez E, Genovés-Crespo M, García-Jiménez MD, Honguero-Martínez AF, Rombolá CA, Simón-Adiego CM, et al: Prognostic influence of loss of blood group A antigen expression in pathologic stage I non-small-cell lung cancer. Arch Bronconeumol. 48:49–54. 2012.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

27 

Joh HK, Cho E and Choueiri TK: ABO blood group and risk of renal cell cancer. Cancer Epidemiol. 36:528–532. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Oguz A, Unal D, Tasdemir A, Karahan S, Aykas F, Mutlu H, Cihan YB and Kanbay M: Lack of any association between blood groups and lung cancer, independent of histology. Asian Pac J Cancer Prev. 14:453–456. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Urun Y, Utkan G, Cangir AK, Oksuzoglu OB, Ozdemir N, Oztuna DG, Kocaman G, Coşkun HŞ, Kaplan MA, Yuksel C, et al: Association of ABO blood group and risk of lung cancer in a multicenter study in Turkey. Asian Pac J Cancer Prev. 14:2801–2803. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, Fuchs CS, Petersen GM, Arslan AA, Bueno-de-Mesquita HB, Gross M, Helzlsouer K, Jacobs EJ, et al: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 41:986–990. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Suadicani P, Hein HO and Gyntelberg F: ABO phenotypes and inflammation-related predictors of lung cancer mortality: The Copenhagen Male Study-a 16-year follow-up. Eur Respir J. 30:13–20. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Klarmann D, Eggert C, Geisen C, Becker S, Seifried E, Klingebiel T and Kreuz W: Association of ABO(H) and I blood group system development with von Willebrand factor and factor VIII plasma levels in children and adolescents. Transfusion. 50:1571–1580. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Bowen DJ: An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13. J Thromb Haemost. 1:33–40. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Wagner DD, Mayadas T and Marder VJ: Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor. J Cell Biol. 102:1320–1324. 1986. View Article : Google Scholar : PubMed/NCBI

35 

Choi Q, Kim JE, Kim SY, Han KS and Kim HK: Influence of ABO type on global coagulation assay results: Effect of coagulation factor VIII. Clin Chem Lab Med. 53:1425–1432. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Mannucci PM, Capoferri C and Canciani MT: Plasma levels of von Willebrand factor regulate ADAMTS-13, its major cleaving protease. Br J Haematol. 126:213–218. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu X, Chen X, Yang J and Guo R: Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer. Oncol Lett 14: 3787-3794, 2017.
APA
Liu, X., Chen, X., Yang, J., & Guo, R. (2017). Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer. Oncology Letters, 14, 3787-3794. https://doi.org/10.3892/ol.2017.6619
MLA
Liu, X., Chen, X., Yang, J., Guo, R."Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer". Oncology Letters 14.3 (2017): 3787-3794.
Chicago
Liu, X., Chen, X., Yang, J., Guo, R."Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer". Oncology Letters 14, no. 3 (2017): 3787-3794. https://doi.org/10.3892/ol.2017.6619
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Chen X, Yang J and Guo R: Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer. Oncol Lett 14: 3787-3794, 2017.
APA
Liu, X., Chen, X., Yang, J., & Guo, R. (2017). Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer. Oncology Letters, 14, 3787-3794. https://doi.org/10.3892/ol.2017.6619
MLA
Liu, X., Chen, X., Yang, J., Guo, R."Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer". Oncology Letters 14.3 (2017): 3787-3794.
Chicago
Liu, X., Chen, X., Yang, J., Guo, R."Association of ABO blood groups with von Willebrand factor, factor VIII and ADAMTS‑13 in patients with lung cancer". Oncology Letters 14, no. 3 (2017): 3787-3794. https://doi.org/10.3892/ol.2017.6619
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team