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Article

Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer

  • Authors:
    • Shuxia Li
    • Yanqi Yang
    • Yanping Ding
    • Xiaofei Tang
    • Zheng Sun
  • View Affiliations / Copyright

    Affiliations: Department of Oral Medicine, Beijing Stomatological Hospital of China, Capital Medical University, Beijing 100050, P.R. China, Department of Orthodontics, School of Dentistry, Hong Kong University, Hong Kong 999077, P.R. China, Institute of Stomatology, Capital Medical University, Beijing 100050, P.R. China
  • Pages: 3774-3779
    |
    Published online on: July 20, 2017
       https://doi.org/10.3892/ol.2017.6626
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Abstract

The present study aimed to investigate the impact of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer. A total of 16 oral leukoplakia cases accompanied by low‑moderate epithelial dysplasia, 12 cases of oral leukoplakia accompanied by severe epithelial dysplasia, 17 cases of high‑moderate differentiated oral squamous cell carcinoma and 10 cases of normal oral mucosa were selected. Immunohistochemistry was used to detect the expression levels of survivin, caspase‑3, and caspase inhibitor factor VIII in lesions from each group. Terminal deoxynucleotidyl transferase 2'‑deoxyuridine, 5'‑triphosphate nick end labeling was performed to detect the apoptotic index of oral leukoplakia and cancer tissue. Immunohistochemistry revealed increased expression levels of survivin in oral cancer tissues, as compared with the normal mucosa, whereas the expression of Caspase‑3 was decreased during malignant transformation. Microvascular density (MVD) was increased from 28.49±11.87 strips/mm2 (mean ± standard deviation, normal control group) to 91.98±40.20 strips/mm2 (oral cancer group). Therefore, survivin may serve an important role in oral cancer, as its expression was increased in association with a downward trend in caspase‑3 expression and apoptotic index, whereas MVD was significantly increased.
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Copy and paste a formatted citation
Spandidos Publications style
Li S, Yang Y, Ding Y, Tang X and Sun Z: Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer. Oncol Lett 14: 3774-3779, 2017.
APA
Li, S., Yang, Y., Ding, Y., Tang, X., & Sun, Z. (2017). Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer. Oncology Letters, 14, 3774-3779. https://doi.org/10.3892/ol.2017.6626
MLA
Li, S., Yang, Y., Ding, Y., Tang, X., Sun, Z."Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer". Oncology Letters 14.3 (2017): 3774-3779.
Chicago
Li, S., Yang, Y., Ding, Y., Tang, X., Sun, Z."Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer". Oncology Letters 14, no. 3 (2017): 3774-3779. https://doi.org/10.3892/ol.2017.6626
Copy and paste a formatted citation
x
Spandidos Publications style
Li S, Yang Y, Ding Y, Tang X and Sun Z: Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer. Oncol Lett 14: 3774-3779, 2017.
APA
Li, S., Yang, Y., Ding, Y., Tang, X., & Sun, Z. (2017). Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer. Oncology Letters, 14, 3774-3779. https://doi.org/10.3892/ol.2017.6626
MLA
Li, S., Yang, Y., Ding, Y., Tang, X., Sun, Z."Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer". Oncology Letters 14.3 (2017): 3774-3779.
Chicago
Li, S., Yang, Y., Ding, Y., Tang, X., Sun, Z."Impacts of survivin and caspase‑3 on apoptosis and angiogenesis in oral cancer". Oncology Letters 14, no. 3 (2017): 3774-3779. https://doi.org/10.3892/ol.2017.6626
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