Open Access

Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor

  • Authors:
    • Gen Inoue
    • Takayuki Imura
    • Masayuki Miyagi
    • Wataru Saito
    • Ryo Tazawa
    • Toshiyuki Nakazawa
    • Masashi Takaso
  • View Affiliations

  • Published online on: July 24, 2017     https://doi.org/10.3892/ol.2017.6655
  • Pages: 4005-4010
  • Copyright: © Inoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Although denosumab has been reported to induce effective clinical results with respect to tumor shrinkage in a short‑term follow‑up clinical study, total spondylectomy is recognized as the treatment of choice for eradicating giant cell tumors (GCTs) of the spine. The present study reports the case involving a GCT in the 11th thoracic vertebra complicated by idiopathic scoliosis and treated using total en bloc spondylectomy (TES) with preoperative denosumab therapy. A 35‑year‑old woman received preoperative denosumab therapy for 8 months, followed by surgery using a computed tomography (CT)‑based navigation system that optimized accuracy by recognizing the area of the detached parietal pleura, the irregular border of the collapsed vertebra, and the adjacent vertebra. Complete en bloc resection of the vertebra could be performed, suggesting denosumab can be an effective adjuvant therapy which can reduce the complexity of TES and CT‑navigation system facilitated the safe use of this surgical method in a patient with idiopathic scoliosis.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Inoue G, Imura T, Miyagi M, Saito W, Tazawa R, Nakazawa T and Takaso M: Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncol Lett 14: 4005-4010, 2017
APA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., & Takaso, M. (2017). Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncology Letters, 14, 4005-4010. https://doi.org/10.3892/ol.2017.6655
MLA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14.4 (2017): 4005-4010.
Chicago
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14, no. 4 (2017): 4005-4010. https://doi.org/10.3892/ol.2017.6655