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Article Open Access

Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor

  • Authors:
    • Gen Inoue
    • Takayuki Imura
    • Masayuki Miyagi
    • Wataru Saito
    • Ryo Tazawa
    • Toshiyuki Nakazawa
    • Masashi Takaso
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252‑0374, Japan
    Copyright: © Inoue et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4005-4010
    |
    Published online on: July 24, 2017
       https://doi.org/10.3892/ol.2017.6655
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Abstract

Although denosumab has been reported to induce effective clinical results with respect to tumor shrinkage in a short‑term follow‑up clinical study, total spondylectomy is recognized as the treatment of choice for eradicating giant cell tumors (GCTs) of the spine. The present study reports the case involving a GCT in the 11th thoracic vertebra complicated by idiopathic scoliosis and treated using total en bloc spondylectomy (TES) with preoperative denosumab therapy. A 35‑year‑old woman received preoperative denosumab therapy for 8 months, followed by surgery using a computed tomography (CT)‑based navigation system that optimized accuracy by recognizing the area of the detached parietal pleura, the irregular border of the collapsed vertebra, and the adjacent vertebra. Complete en bloc resection of the vertebra could be performed, suggesting denosumab can be an effective adjuvant therapy which can reduce the complexity of TES and CT‑navigation system facilitated the safe use of this surgical method in a patient with idiopathic scoliosis.
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1 

Rockberg J, Bach BA, Amelio J, Hernandez RK, Sobocki P, Engellau J, Bauer HC and Liede A: Incidence Trends in the diagnosis of giant cell tumor of bone in Sweden since 1958. J Bone Joint Surg Am. 97:1756–1766. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Gong L, Liu W, Sun X, Sajdik C, Tian X, Niu X and Huang X: Histological and clinical characteristics of malignant giant cell tumor of bone. Virchows Arch. 460:327–334. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Shimada Y, Hongo M, Miyakoshi N, Kasukawa Y, Ando S, Itoi E and Abe E: Giant cell tumor of fifth lumbar vertebrae: Two case reports and review of the literature. Spine J. 7:499–505. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Niu X, Zhang Q, Hao L, Ding Y, Li Y, Xu H and Liu W: Giant cell tumor of the extremity: Retrospective analysis of 621 Chinese patients from one institution. J Bone Joint Surg Am. 94:461–467. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wang K, Zhu B, Yang S, Liu Z, Yu M and Liu X: Primary diffuse-type tenosynovial giant cell tumor of the spine: A report of 3 cases and systemic review of the literature. Turk Neurosurg. 24:804–813. 2014.PubMed/NCBI

6 

Xu W, Li X, Huang W, Wang Y, Han S, Chen S, Xu L, Yang X, Liu T and Xiao J: Factors affecting prognosis of patients with giant cell tumors of the mobile spine: Retrospective analysis of 102 patients in a single center. Ann Surg Oncol. 20:804–810. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Goldschlager T, Dea N, Boyd M, Reynolds J, Patel S, Rhines LD, Mendel E, Pacheco M, Ramos E, Mattei TA and Fisher CG: Giant cell tumors of the spine: Has denosumab changed the treatment paradigm? J Neurosurg Spine. 22:526–533. 2015. View Article : Google Scholar : PubMed/NCBI

8 

de Carvalho Cavalcante RA, Silva Marques RA, dos Santos VG, Sabino E, Fraga AC Jr, Zaccariotti VA, Arruda JB and Fernandes YB: Lumbar spondylectomy for giant cell tumor after denosumab therapy. Spine (Phila Pa 1976). 41:E178–E182. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Müller DA, Beltrami G, Scoccianti G, Campanacci DA, Franchi A and Capanna R: Risks and benefits of combining denosumab and surgery in giant cell tumor of bone-a case series. World J Surg Oncol. 14:2812016. View Article : Google Scholar : PubMed/NCBI

10 

Deveci MA, Paydaş S, Gönlüşen G, Özkan C, Biçer ÖS and Tekin M: Clinical and pathological results of denosumab treatment for giant cell tumors of bone: Prospective study of 14 cases. Acta Orthop Traumatol Turc. 51:1–6. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, et al: Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: Interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 14:901–908. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Tomita K, Kawahara N, Murakami H and Demura S: Total en bloc spondylectomy for spinal tumors: Improvement of the technique and its associated basic background. J Orthop Sci. 11:3–12. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Fisher CG, Saravanja DD, Dvorak MF, Rampersaud YR, Clarkson PW, Hurlbert J, Fox R, Zhang H, Lewis S, Riaz S, et al: Surgical management of primary bone tumors of the spine: Validation of an approach to enhance cure and reduce local recurrence. Spine (Phila Pa 1976). 36:830–836. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Bandiera S, Boriani S, Donthineni R, Amendola L, Cappuccio M and Gasbarrini A: Complications of en bloc resections in the spine. Orthop Clin North Am. 40:125–131, vii. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Arbeitsgemeinschaft Knochentumoren, . Becker WT, Dohle J, Bernd L, Braun A, Cserhati M, Enderle A, Hovy L, Matejovsky Z, Szendroi M, et al: Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. J Bone Joint Surg Am. 90:1060–1067. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, et al: Denosumab in patients with giant-cell tumour of bone: An open-label, phase 2 study. Lancet Oncol. 11:275–280. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Agarwal A, Larsen BT, Buadu LD, Dunn J, Crawford R, Daniel J and Bishop MC: Denosumab chemotherapy for recurrent giant-cell tumor of bone: A case report of neoadjuvant use enabling complete surgical resection. Case Rep Oncol Med. 2013:4963512013.PubMed/NCBI

18 

Aponte-Tinao LA, Piuzzi NS, Roitman P and Farfalli GL: A high-grade sarcoma arising in a patient with recurrent benign giant cell tumor of the proximal tibia while receiving treatment with denosumab. Clin Orthop Relat Res. 473:3050–3055. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Broehm CJ, Garbrecht EL, Wood J and Bocklage T: Two cases of sarcoma arising in giant cell tumor of bone treated with denosumab. Case Rep Med. 2015:7671982015. View Article : Google Scholar : PubMed/NCBI

20 

Kotani Y, Abumi K, Ito M, Takahata M, Sudo H, Ohshima S and Minami A: Accuracy analysis of pedicle screw placement in posterior scoliosis surgery: Comparison between conventional fluoroscopic and computer-assisted technique. Spine (Phila Pa 1976). 32:1543–1550. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Sakai Y, Matsuyama Y, Nakamura H, Katayama Y, Imagama S, Ito Z and Ishiguro N: Segmental pedicle screwing for idiopathic scoliosis using computer-assisted surgery. J Spinal Disord Tech. 21:181–186. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Takahashi J, Hirabayashi H, Hashidate H, Ogihara N and Kato H: Accuracy of multilevel registration in image-guided pedicle screw insertion for adolescent idiopathic scoliosis. Spine (Phila PA 1976). 35:347–352. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Krettek C, Geerling J, Bastian L, Citak M, Rücker F, Kendoff D and Hüfner T: Computer aided tumor resection in the pelvis. Injury. 35:S-A79–S-A83. 2004. View Article : Google Scholar

24 

Hüfner T, Kfuri M Jr, Galanski M, Bastian L, Loss M, Pohlemann T and Krettek C: New indications for computer-assisted surgery: Tumor resection in the pelvis. Clin Orthop Relat Res. 426:219–225. 2004. View Article : Google Scholar

25 

Wong KC and Kumta SM: Joint-preserving tumor resection and reconstruction using image-guided computer navigation. Clin Orthop Relat Res. 471:762–773. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Cho HS, Oh JH, Han I and Kim HS: Joint-preserving limb salvage surgery under navigation guidance. J Surg Oncol. 100:227–232. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Li J, Wang Z, Guo Z, Chen GJ, Yang M and Pei GX: Irregular osteotomy in limb salvage for juxta-articular osteosarcoma under computer-assisted navigation. J Surg Oncol. 106:411–416. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Tian W, Weng C, Liu B, Li Q, Sun YQ, Yuan Q, Zhang B, Wang YQ and He D: Intraoperative 3-dimensional navigation and ultrasonography during posterior decompression with instrumented fusion for ossification of the posterior longitudinal ligament in the thoracic spine. J Spinal Disord Tech. 26:E227–E234. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Inoue G, Imura T, Miyagi M, Saito W, Tazawa R, Nakazawa T and Takaso M: Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncol Lett 14: 4005-4010, 2017.
APA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., & Takaso, M. (2017). Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncology Letters, 14, 4005-4010. https://doi.org/10.3892/ol.2017.6655
MLA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14.4 (2017): 4005-4010.
Chicago
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14, no. 4 (2017): 4005-4010. https://doi.org/10.3892/ol.2017.6655
Copy and paste a formatted citation
x
Spandidos Publications style
Inoue G, Imura T, Miyagi M, Saito W, Tazawa R, Nakazawa T and Takaso M: Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncol Lett 14: 4005-4010, 2017.
APA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., & Takaso, M. (2017). Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor. Oncology Letters, 14, 4005-4010. https://doi.org/10.3892/ol.2017.6655
MLA
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14.4 (2017): 4005-4010.
Chicago
Inoue, G., Imura, T., Miyagi, M., Saito, W., Tazawa, R., Nakazawa, T., Takaso, M."Total en bloc spondylectomy of the eleventh thoracic vertebra following denosumab therapy for the treatment of a giant cell tumor". Oncology Letters 14, no. 4 (2017): 4005-4010. https://doi.org/10.3892/ol.2017.6655
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