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Article

Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer

  • Authors:
    • Yu‑Qian Wang
    • Qiong‑Jie Zhi
    • Xin‑Yue Wang
    • Dong‑Sheng Yue
    • Kai Li
    • Ri‑Cheng Jiang
  • View Affiliations / Copyright

    Affiliations: Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Hexi, Tianjin 300060, P.R. China
  • Pages: 4331-4338
    |
    Published online on: July 24, 2017
       https://doi.org/10.3892/ol.2017.6660
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Abstract

The aim of the present study was to investigate the prognostic value of the combined platelet (PLT), fibrinogen (FBG), neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) (CO‑NPF) for postoperative outcomes in patients with lung adenosquamous cancer (ASC). Test results from patients who presented at The Cancer Institute and Hospital of Tianjin Medical University between January 2005 and December 2013 were retrospectively reviewed. CO‑NPF was scored between 0 and 4 according to increased PLT, FBG, NLR and PLR prior to being split into two groups based on the presence (≥2) or absence (<2) of the combination of increased inflammatory indexes. In total, data from 134 patients with ASC were reviewed for the present study. Multivariate analysis identified that increased CO‑NPF (P=0.001 and P<0.001, respectively), PLR (P=0.011 and P=0.001, respectively) and FBG (P=0.001 and P<0.001, respectively) were independently associated with shorter disease‑free survival (DFS) and overall survival (OS). NLR (P=0.006) and PLT (P=0.001) were independent prognostic factors for OS. The area under the receiver operating characteristic curves of CO‑NPF (area under the curve, 0.652, P=0.008, 95% confidence interval, 0.551‑0.752) was increased compared with NLR, PLR, PLT and FBG individually, suggesting that CO‑NPF has greater predictive value. CO‑NPF was significantly and independently associated with shorter DFS and OS, and had greater predictive value compared with NLR, PLR, PLT and FBG in patients with ASC who underwent surgery.
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1 

Chang S, Dai M, Ren JS, Chen YH and Guo LW: Estimates and prediction on incidence, mortality and prevalence of lung cancer in China in 2008. Zhonghua Liu Xing Bing Xue Za Zhi. 33:391–394. 2012.(In Chinese). PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. In J Cancer. 127:2893–2917. 2010.

3 

Fitzgibbons PL and Kern WH: Adenosquamous carcinoma of the lung: A clinical and pathologic study of seven cases. Hum Pathol. 16:463–466. 1985. View Article : Google Scholar : PubMed/NCBI

4 

Ishida T, Kaneko S, Yokoyama H, Inoue T, Sugio K and Sugimachi K: Adenosquamous carcinoma of the lung. Clinicopathologic and immunohistochemical features. Am J Clin Pathol. 97:678–685. 1992. View Article : Google Scholar : PubMed/NCBI

5 

Shimizu J, Oda M, Hayashi Y, Nonomura A and Watanabe Y: A clinicopathologic study of resected cases of adenosquamous carcinoma of the lung. Chest. 109:989–994. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Gibbs AR and Thunnissen FB: Histological typing of lung and pleural tumours: Third edition. J Clin Pathol. 54:498–499. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Sridhar KS, Bounassi MJ, Raub W Jr and Richman SP: Clinical features of adenosquamous lung carcinoma in 127 patients. Am Rev Respir Dis. 142:19–23. 1990. View Article : Google Scholar : PubMed/NCBI

8 

Lee Y, Chung JH, Kim SE, Kim TJ and Lee KW: Adenosquamous carcinoma of the lung: CT, FDG PET, and clinicopathologic findings. Clin Nucl Med. 39:107–112. 2014.PubMed/NCBI

9 

Maeda H, Matsumura A, Kawabata T, Suito T, Kawashima O, Watanabe T, Okabayashi K and Kubota I: Japan National Hospital Organization Study Group for Lung Cancer: Adenosquamous carcinoma of the lung: Surgical results as compared with squamous cell and adenocarcinoma cases. Eur J Cardiothorac Surg. 41:357–361. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Mordant P, Grand B, Cazes A, Foucault C, Dujon A, Le Pimpec Barthes F and Riquet M: Adenosquamous carcinoma of the lung: Surgical management, pathologic characteristics, and prognostic implications. Ann Thorac Surg. 95:1189–1195. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Coussens LM and Werb Z: Inflammation and cancer. Nature. 420:860–867. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Ji Y, Sheng L, Du X, Qiu G and Su D: Elevated platelet count is a strong predictor of poor prognosis in stage I non-small cell lung cancer patients. Platelets. 26:138–142. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Jiang HG, Li J, Shi SB, Chen P, Ge LP, Jiang Q and Tang XP: Value of fibrinogen and D-dimer in predicting recurrence and metastasis after radical surgery for non-small cell lung cancer. Med Oncol. 31:222014. View Article : Google Scholar : PubMed/NCBI

15 

Kim KH, Park TY, Lee JY, Lee SM, Yim JJ, Yoo CG, Kim YW, Han SK and Yang SC: Prognostic significance of initial platelet counts and fibrinogen level in advanced non-small cell lung cancer. J Korean Med Sci. 29:507–511. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Kos M, Hocazade C, Kos FT, Uncu D, Karakas E, Dogan M, Uncu HG, Yildirim N and Zengin N: Prognostic role of pretreatment platelet/lymphocyte ratio in patients with non-small cell lung cancer. Wien Klin Wochenschr. 128:635–640. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kwon HC, Kim SH, Oh SY, Lee S and Lee JH, Choi HJ, Park KJ, Roh MS, Kim SG, Kim HJ and Lee JH: Clinical significance of preoperative neutrophil-lymphocyte versus platelet-lymphocyte ratio in patients with operable colorectal cancer. Biomarkers. 17:216–222. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Pinato DJ, Shiner RJ, Seckl MJ, Stebbing J, Sharma R and Mauri FA: Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer. Br J Cancer. 110:1930–1935. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Sheng L, Luo M, Sun X, Lin N, Mao W and Su D: Serum fibrinogen is an independent prognostic factor in operable nonsmall cell lung cancer. Int J Cancer. 133:2720–2725. 2013.PubMed/NCBI

20 

Yao Y, Yuan D, Liu H, Gu X and Song Y: Pretreatment neutrophil to lymphocyte ratio is associated with response to therapy and prognosis of advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy. Cancer Immunol Immunother. 62:471–479. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Yu D, Liu B, Zhang L and Du K: Platelet count predicts prognosis in operable non-small cell lung cancer. Exp Ther Med. 5:1351–1354. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Zhu JF, Cai L, Zhang XW, Wen YS, Su XD, Rong TH and Zhang LJ: High plasma fibrinogen concentration and platelet count unfavorably impact survival in non-small cell lung cancer patients with brain metastases. Chin J Cancer. 33:96–104. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Unal D, Eroglu C, Kurtul N, Oguz A and Tasdemir A: Are neutrophil/lymphocyte and platelet/lymphocyte rates in patients with non-small cell lung cancer associated with treatment response and prognosis? Asian Pac J Cancer Prev. 14:5237–5242. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Vallières E, Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, Chansky K, Shaikh Z and Goldstraw P: International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions: The IASLC Lung Cancer Staging Project: Proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol. 4:1049–1059. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Dubernard V, Arbeille BB, Lemesle MB and Legrand C: Evidence for an alpha-granular pool of the cytoskeletal protein alpha-actinin in human platelets that redistributes with the adhesive glycoprotein thrombospondin-1 during the exocytotic process. Arterioscler Thromb Vasc Biol. 17:2293–2305. 1997. View Article : Google Scholar : PubMed/NCBI

26 

Kaplan KL, Broekman MJ, Chernoff A, Lesznik GR and Drillings M: Platelet alpha-granule proteins: Studies on release and subcellular localization. Blood. 53:604–618. 1979.PubMed/NCBI

27 

Qian X and Tuszynski GP: Expression of thrombospondin-1 in cancer: A role in tumor progression. Proc Soc Exp Biol Med. 212:199–207. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Zheng S, Shen J, Jiao Y, Liu Y, Zhang C, Wei M, Hao S and Zeng X: Platelets and fibrinogen facilitate each other in protecting tumor cells from natural killer cytotoxicity. Cancer Sci. 100:859–865. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Zhang J, Huang SH, Li H, Li Y, Chen XL, Zhang WQ, Chen HG and Gu LJ: Preoperative lymphocyte count is a favorable prognostic factor of disease-free survival in non-small-cell lung cancer. Med Oncol. 30:3522013. View Article : Google Scholar : PubMed/NCBI

30 

Zhang H, Zhang L, Zhu K, Shi B, Yin Y, Zhu J, Yue D, Zhang B and Wang C: Prognostic significance of combination of preoperative platelet count and neutrophil-lymphocyte ratio (COP-NLR) in patients with non-small cell lung cancer: Based on a large cohort study. PLoS One. 10:e01264962015. View Article : Google Scholar : PubMed/NCBI

31 

McMillan DC: The systemic inflammation-based Glasgow prognostic score: A decade of experience in patients with cancer. Cancer Treat Rev. 39:534–540. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Wu PF, Huang WC, Yang JC, Lu YS, Shih JY, Wu SG, Lin CH and Cheng AL: Phosphorylated insulin-like growth factor-1 receptor (pIGF1R) is a poor prognostic factor in brain metastases from lung adenocarcinomas. J Neurooncol. 115:61–70. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Kwon KY, Ro JY, Singhal N, Killen DE, Sienko A, Allen TC, Zander DS, Barrios R, Haque A and Cagle PT: MUC4 expression in non-small cell lung carcinomas: Relationship to tumor histology and patient survival. Arch Pathol Lab Med. 131:593–598. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang YQ, Zhi QJ, Wang XY, Yue DS, Li K and Jiang RC: Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncol Lett 14: 4331-4338, 2017.
APA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., & Jiang, R. (2017). Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncology Letters, 14, 4331-4338. https://doi.org/10.3892/ol.2017.6660
MLA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14.4 (2017): 4331-4338.
Chicago
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14, no. 4 (2017): 4331-4338. https://doi.org/10.3892/ol.2017.6660
Copy and paste a formatted citation
x
Spandidos Publications style
Wang YQ, Zhi QJ, Wang XY, Yue DS, Li K and Jiang RC: Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncol Lett 14: 4331-4338, 2017.
APA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., & Jiang, R. (2017). Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer. Oncology Letters, 14, 4331-4338. https://doi.org/10.3892/ol.2017.6660
MLA
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14.4 (2017): 4331-4338.
Chicago
Wang, Y., Zhi, Q., Wang, X., Yue, D., Li, K., Jiang, R."Prognostic value of combined platelet, fibrinogen, neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in patients with lung adenosquamous cancer". Oncology Letters 14, no. 4 (2017): 4331-4338. https://doi.org/10.3892/ol.2017.6660
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