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Article

Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer

  • Authors:
    • Libo Si
    • Hui Tian
    • Weiming Yue
    • Lin Li
    • Shuhai Li
    • Cun Gao
    • Lei Qi
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 4325-4330
    |
    Published online on: July 25, 2017
       https://doi.org/10.3892/ol.2017.6667
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Abstract

MicroRNAs (miRNAs/miRs) are a class of small, highly conserved non‑coding RNAs that can serve either oncogenic or tumor‑suppressive roles in a wide variety of tumors. miR‑200c is a member of the miR‑200 family whose specific role in non‑small cell lung cancer (NSCLC) has not yet been elucidated. The purpose of the present study was to detect the expression level of miR‑200c in NSCLC, and to analyze its association with clinicopathological factors and patient prognosis. The present study determined the expression levels of miR‑200c in 110 tumor samples collected from patients diagnosed with NSCLC who underwent complete tumor resection with regional lymph node dissection, as assessed by reverse transcription‑quantitative polymerase chain reaction. The association between the expression level of miR‑200c and clinicopathological features and patient prognosis was also analyzed. The results showed that miR‑200c overexpression was detected in 66 of the 110 cases and was significantly associated with positive lymph node metastasis (P<0.001). Univariate survival analysis demonstrated that high miR‑200c expression, positive lymph node metastasis and advanced Tumor‑Node‑Metastasis (TNM) classification stage significantly predicted decreased 5‑year disease‑free survival rates (all P<0.05) and poor 5‑year overall survival rates (all P<0.01), respectively. The results of multivariate Cox regression analysis showed that TNM stage and miR‑200c expression retained its significance as an independent prognostic factor for unfavorable 5‑year disease‑free survival rates (P<0.05) and poor 5‑year overall survival rates (P<0.01). The present findings suggest that miR‑200c overexpression is significantly associated with poor survival rates in NSCLC and that miR‑200c could play an oncogenic role. miR‑200c may have clinical potential as a promising prognostic predictor for patients with NSCLC.
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1 

Sibille A, Paulus A, Martin M, Bourhaba M, Barthélemy N, Radermecker M, Corhay JL, Louis R and Duysinx B: Management of non-small cell lung cancer. Rev Med Liege. 70:432–441. 2015.(In French). PubMed/NCBI

2 

Venkatesulu BP, Mallick S, Singh A and Julka PK: Non small cell carcinoma of lung with metachronous breast metastasis and cardiac tamponade: Unusual presentation of a common cancer. J Egypt Natl Canc Inst. 27:165–169. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Sun Z, Wang Z, Liu X and Wang D: New development of inhibitors targeting the PI3K/AKT/mTOR pathway in personalized treatment of non-small-cell lung cancer. Anticancer Drugs. 26:1–14. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wu CF, Fu JY, Yeh CJ, Liu YH, Hsieh MJ, Wu YC, Wu CY, Tsai YH and Chou WC: Recurrence risk factors analysis for stage I non-small cell lung cancer. Medicine (Baltimore). 94:e13372015. View Article : Google Scholar : PubMed/NCBI

5 

Bartel DP: MicroRNAs: Target recognition and regulatory functions. Cell. 136:215–233. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Feng B, Zhang K, Wang R and Chen L: Non-small-cell lung cancer and miRNAs: Novel biomarkers and promising tools for treatment. Clin Sci (Lond). 128:619–634. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ghasemkhani N, Shadvar S, Masoudi Y, Talaei AJ, Yahaghi E, Goudarzi PK and Shakiba E: Down-regulated MicroRNA 148b expression as predictive biomarker and its prognostic significance associated with clinicopathological features in non-small-cell lung cancer patients. Diagn Pathol. 10:1642015. View Article : Google Scholar : PubMed/NCBI

8 

Bai T, Dong DS and Pei L: Synergistic antitumor activity of resveratrol and miR-200c in human lung cancer. Oncol Rep. 31:2293–2297. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Shi L, Zhang S, Wu H, Zhang L, Dai X, Hu J, Xue J, Liu T, Liang Y and Wu G: MiR-200c increases the radiosensitivity of non-small-cell lung cancer cell line A549 by targeting VEGF-VEGFR2 pathway. PLoS One. 8:e783442013. View Article : Google Scholar : PubMed/NCBI

10 

Li J, Li X, Ren S, Chen X, Zhang Y, Zhou F, Zhao M, Zhao C, Chen X, Cheng N, et al: miR-200c overexpression is associated with better efficacy of EGFR-TKIs in non-small cell lung cancer patients with EGFR wild-type. Oncotarget. 5:7902–7916. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Liu XG, Zhu WY, Huang YY, Ma LN, Zhou SQ, Wang YK, Zeng F, Zhou JH and Zhang YK: High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer. Med Oncol. 29:618–626. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kim MK, Jung SB, Kim JS, Roh MS, Lee JH, Lee EH and Lee HW: Expression of microRNA miR-126 and miR-200c is associated with prognosis in patients with non-small cell lung cancer. Virchows Arch. 465:463–471. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Li D, Zhuang Y, Shi Q, Wei W and Ju X: Overexpression of miR-708 and its targets in the childhood common precursor B-cell ALL. Pediatr Blood Cancer. 60:2060–2067. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Hansen O, Schytte T, Nielsen M and Brink C: Age dependent prognosis in concurrent chemo-radiation of locally advanced NSCLC. Acta Oncol. 54:333–339. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Strøm HH, Bremnes RM, Sundstrøm SH, Helbekkmo N and Aasebø U: Poor prognosis patients with inoperable locally advanced NSCLC and large tumors benefit from palliative chemoradiotherapy: A subset analysis from a randomized clinical phase III trial. J Thorac Oncol. 9:825–833. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Liu CM, Peng CY, Liao YW, Lu MY, Tsai ML, Yeh JC, Yu CH and Yu CC: Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction. J Formos Med Assoc. 116:41–48. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Xie Y, Wehrkamp CJ, Li J, Wang Y, Wang Y, Mott JL and Oupický D: Delivery of miR-200c Mimic with Poly (amido amine) CXCR4 antagonists for combined inhibition of cholangiocarcinoma cell invasiveness. Mol Pharm. 13:1073–1080. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Zhang H, Liu J, Qu D, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe GL, Lee HK, et al: Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes. 65:1196–1207. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Mutlu M, Raza U, Saatci Ö, Eyüpoğlu E, Yurdusev E and Şahin Ö: MiR-200c: A versatile watchdog in cancer progression, EMT, and drug resistance. J Mol Med (Berl). 94:629–644. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Dimri M, Kang M and Dimri GP: A miR-200c/141-BMI1 autoregulatory loop regulates oncogenic activity of BMI1 in cancer cells. Oncotarget. 7:36220–36234. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Ceppi P, Mudduluru G, Kumarswamy R, Rapa I, Scagliotti GV, Papotti M and Allgayer H: Loss of miR-200c expression induces an aggressive, invasive, and chemoresistant phenotype in non-small cell lung cancer. Mol Cancer Res. 8:1207–1216. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Tejero R, Navarro A, Campayo M, Viñolas N, Marrades RM, Cordeiro A, Ruíz-Martínez M, Santasusagna S, Molins L, Ramirez J and Monzó M: miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma. PLoS One. 9:e1018992014. View Article : Google Scholar : PubMed/NCBI

24 

Brücher BL and Jamall IS: Cell-cell communication in the tumor microenvironment, carcinogenesis, and anticancer treatment. Cell Physiol Biochem. 34:213–243. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wang L, Li G, Yao ZQ, Moorman JP and Ning S: MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV. Rev Med Virol. 25:320–341. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Bizzarri M and Cucina A: Tumor and the microenvironment: A chance to reframe the paradigm of carcinogenesis? Biomed Res Int. 2014:9340382014. View Article : Google Scholar : PubMed/NCBI

27 

Liu S, Tetzlaff MT, Wang T, Yang R, Xie L, Zhang G, Krepler C, Xiao M, Beqiri M, Xu W, et al: miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Pigment Cell Melanoma Res. 28:431–441. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Tamagawa S, Beder LB, Hotomi M, Gunduz M, Yata K, Grenman R and Yamanaka N: Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma. Int J Mol Med. 33:879–886. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Rajabi H, Alam M, Takahashi H, Kharbanda A, Guha M, Ahmad R and Kufe D: MUC1-C oncoprotein activates the ZEB1/miR-200c regulatory loop and epithelial-mesenchymal transition. Oncogene. 33:1680–1689. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Knezevic J, Pfefferle AD, Petrovic I, Greene SB, Perou CM and Rosen JM: Expression of miR-200c in claudin-low breast cancer alters stem cell functionality, enhances chemosensitivity and reduces metastatic potential. Oncogene. 34:5997–6006. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Gravgaard KH, Lyng MB, Laenkholm AV, Søkilde R, Nielsen BS, Litman T and Ditzel HJ: The miRNA-200 family and miRNA-9 exhibit differential expression in primary versus corresponding metastatic tissue in breast cancer. Breast Cancer Res Treat. 134:207–217. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celià-Terrassa T, Mercatali L, Khan Z, Goodarzi H, Hua Y, et al: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med. 17:1101–1108. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Vilming Elgaaen B, Olstad OK, Haug KB, Brusletto B, Sandvik L, Staff AC, Gautvik KM and Davidson B: Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker. BMC Cancer. 14:802014. View Article : Google Scholar : PubMed/NCBI

34 

Toiyama Y, Hur K, Tanaka K, Inoue Y, Kusunoki M, Boland CR and Goel A: Serum miR-200c is a novel prognostic and metastasis-predictive biomarker in patients with colorectal cancer. Ann Surg. 259:735–743. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Zhang HP, Sun FB and Li SJ: Serum miR-200c expression level as a prognostic biomarker for gastric cancer. Genet Mol Res. 14:15913–15920. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Valladares-Ayerbes M, Reboredo M, Medina-Villaamil V, Iglesias-Díaz P, Lorenzo-Patiño MJ, Haz M, Santamarina I, Blanco M, Fernández-Tajes J, Quindós M, et al: Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer. J Transl Med. 10:1862012. View Article : Google Scholar : PubMed/NCBI

37 

Antolin S, Calvo L, Blanco-Calvo M, Santiago MP, Lorenzo-Patiño MJ, Haz-Conde M, Santamarina I, Figueroa A, Antón-Aparicio LM and Valladares-Ayerbes M: Circulating miR-200c and miR-141 and outcomes in patients with breast cancer. BMC Cancer. 15:2972015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Si L, Tian H, Yue W, Li L, Li S, Gao C and Qi L: Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncol Lett 14: 4325-4330, 2017.
APA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., & Qi, L. (2017). Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncology Letters, 14, 4325-4330. https://doi.org/10.3892/ol.2017.6667
MLA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14.4 (2017): 4325-4330.
Chicago
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14, no. 4 (2017): 4325-4330. https://doi.org/10.3892/ol.2017.6667
Copy and paste a formatted citation
x
Spandidos Publications style
Si L, Tian H, Yue W, Li L, Li S, Gao C and Qi L: Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncol Lett 14: 4325-4330, 2017.
APA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., & Qi, L. (2017). Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer. Oncology Letters, 14, 4325-4330. https://doi.org/10.3892/ol.2017.6667
MLA
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14.4 (2017): 4325-4330.
Chicago
Si, L., Tian, H., Yue, W., Li, L., Li, S., Gao, C., Qi, L."Potential use of microRNA‑200c as a prognostic marker in non‑small cell lung cancer". Oncology Letters 14, no. 4 (2017): 4325-4330. https://doi.org/10.3892/ol.2017.6667
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