miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma

  • Authors:
    • Shin Kim
    • Mei Ling Song
    • Hyeonji Min
    • Ilseon Hwang
    • Seong Kyu Baek
    • Taeg Kyu Kwon
    • Jong‑Wook Park
  • View Affiliations

  • Published online on: July 26, 2017     https://doi.org/10.3892/ol.2017.6674
  • Pages: 4379-4383
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Drosha and Dicer are important regulators of microRNA (miRNA) biogenesis, and it has been suggested that their aberrant regulation may cause colorectal cancer (CRC). The aim of the present study was to evaluate the mRNA expression levels of these two important RNase III nucleases and their association with clinical features in CRC specimens from South Korean patients. The expression levels of Drosha and Dicer mRNA were investigated in 77 CRC tissues and adjacent histologically non‑neoplastic tissues using the quantitative polymerase chain reaction. The expression levels of Drosha and Dicer mRNA were identified to be upregulated in CRC. Neither the Drosha nor the Dicer mRNA expression level was associated with any clinical parameter, including sex, age, TNM stage, body mass index and carcinoembryonic antigen titer in patients with CRC. Furthermore, the expression levels of Drosha and Dicer mRNA were not associated with each other. The miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are significantly upregulated in CRC, suggesting their importance in the pathobiology of colorectal carcinogenesis.
View Figures
View References

Related Articles

Journal Cover

October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Kim S, Song ML, Min H, Hwang I, Baek SK, Kwon TK and Park JW: miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma. Oncol Lett 14: 4379-4383, 2017
APA
Kim, S., Song, M.L., Min, H., Hwang, I., Baek, S.K., Kwon, T.K., & Park, J. (2017). miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma. Oncology Letters, 14, 4379-4383. https://doi.org/10.3892/ol.2017.6674
MLA
Kim, S., Song, M. L., Min, H., Hwang, I., Baek, S. K., Kwon, T. K., Park, J."miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma". Oncology Letters 14.4 (2017): 4379-4383.
Chicago
Kim, S., Song, M. L., Min, H., Hwang, I., Baek, S. K., Kwon, T. K., Park, J."miRNA biogenesis‑associated RNase III nucleases Drosha and Dicer are upregulated in colorectal adenocarcinoma". Oncology Letters 14, no. 4 (2017): 4379-4383. https://doi.org/10.3892/ol.2017.6674