Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet

  • Authors:
    • Kaori Fujiwara
    • Takuya Inoue
    • Yujiro Henmi
    • Yoshimasa Hirata
    • Yutaka Naka
    • Azusa Hara
    • Kazuki Kakimoto
    • Sadaharu Nouda
    • Toshihiko Okada
    • Ken Kawakami
    • Toshihisa Takeuchi
    • Kazuhide Higuchi
  • View Affiliations / Copyright

    Affiliations: Second Department of Internal Medicine, Osaka Medical College, Takatsuki, Osaka 569‑8686, Japan
  • Pages: 4355-4360
    |
    Published online on: August 1, 2017
       https://doi.org/10.3892/ol.2017.6698
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The relationship between type 2 diabetes mellitus and intestinal neoplasia has been shown epidemiologically. A high-fat diet (HFD) is also known to promote insulin resistance, which is a risk factor for intestinal neoplasia. Dipeptidyl peptidase‑4 (DPP‑4) inhibitors are used in the clinic for the treatment of type 2 diabetes and also to prolong the effects of glucagon‑like peptide‑1 (GLP‑1). However, since the intestinotrophic hormone GLP‑2 and chemokines, such as CXCL5 and stromal cell‑derived factor‑1 (SDF‑1), are also substrates of DPP‑4, DPP‑4 inhibitors may increase the risk of intestinal carcinogenesis. In this study, we evaluated the impact of a DPP‑4 inhibitor on intestinal tumorigenesis in ApcMin/+ mice fed a HFD. Six‑week‑old male ApcMin/+ mice were randomized to either a normal diet (10 kcal% fat) group, a HFD (60 kcal% fat) group, or a HFD group treated with sitagliptin (STG). The mice were euthanized nine weeks after the start of treatment. Daily treatment with STG did not increase number of intestinal tumors in the HFD group; however, this increase was not statistically significant. The mucosal concentration of total GLP‑2 was significantly increased in the HFD group. The chemokine protein array showed elevated plasma concentrations of CXCL5 and SDF‑1 in the HFD group. The administration of STG significantly suppressed the levels of plasma CXCL5 and SDF‑1 in mice fed a HFD. Since CXCL5 expression is increased in patients with type 2 diabetes, and GLP‑2, CXCL5 and SDF‑1 are associated with tumor progression, DPP‑4 inhibition may have potential as an agent for decreasing the risk of cancer in obese or diabetic patients.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Tsugane S and Inoue M: Insulin resistance and cancer: Epidemiological evidence. Cancer Sci. 101:1073–1079. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Neville SE, Boye KS, Montgomery WS, Iwamoto K, Okamura M and Hayes RP: Diabetes in Japan: A review of disease burden and approaches to treatment. Diabetes Metab Res Rev. 25:705–716. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Katanoda K, Matsuda T, Matsuda A, Shibata A, Nishino Y, Fujita M, Soda M, Ioka A, Sobue T and Nishimoto H: An updated report of the trends in cancer incidence and mortality in Japan. Jpn J Clin Oncol. 43:492–507. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Vargas AJ and Thompson PA: Diet and nutrient factors in colorectal cancer risk. Nutr Clin Pract. 27:613–623. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Huang XF and Chen JZ: Obesity, the PI3K/Akt signal pathway and colon cancer. Obes Rev. 10:610–616. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Berster JM and Göke B: Type 2 diabetes mellitus as risk factor for colorectal cancer. Arch Physiol Biochem. 114:84–98. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Reimer MK, Holst JJ and Ahrén B: Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice. Eur J Endocrinol. 146:717–727. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Nadkarni P, Chepurny OG and Holz GG: Regulation of glucose homeostasis by GLP-1. Prog Mol Biol Transl Sci. 121:23–65. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Frezza EE, Wachtel MS and Chiriva-Internati M: The multiple faces of glucagon-like peptide-1-obesity, appetite, and stress: What is next? A review. Dig Dis Sci. 52:643–649. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Takasaki K, Takada H, Nakajima T, Ueno K, Ushiki J and Higo K: Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. Eur J Pharmacol. 505:237–241. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Takasaki K, Nakajima T, Ueno K, Nomoto Y and Higo K: Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. J Pharmacol Sci. 95:291–293. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Dubé PE and Brubaker PL: Frontiers in glucagon-like peptide-2: Multiple actions, multiple mediators. Am J Physiol Endocrinol Metab. 293:E460–E465. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Drozdowski L and Thomson AB: Intestinal hormones and growth factors: Effects on the small intestine. World J Gastroenterol. 15:385–406. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Hartmann B, Thulesen J, Kissow H, Thulesen S, Orskov C, Ropke C, Poulsen SS and Holst JJ: Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice. Endocrinology. 141:4013–4020. 2000. View Article : Google Scholar : PubMed/NCBI

16 

Boushey RP, Yusta B and Drucker DJ: Glucagon-like peptide 2 decreases mortality and reduces the severity of indomethacin-induced murine enteritis. Am J Physiol. 277:E937–E947. 1999.PubMed/NCBI

17 

Fujiwara K, Inoue T, Yorifuji N, Iguchi M, Sakanaka T, Narabayashi K, Kakimoto K, Nouda S, Okada T, Ishida K, et al: Combined treatment with dipeptidyl peptidase 4 (DPP4) inhibitor sitagliptin and elemental diets reduced indomethacin-induced intestinal injury in rats via the increase of mucosal glucagon-like peptide-2 concentration. J Clin Biochem Nutr. 56:155–162. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Inoue T, Higashiyama M, Kaji I, Rudenkyy S, Higuchi K, Guth PH, Engel E, Kaunitz JD and Akiba Y: Dipeptidyl peptidase IV inhibition prevents the formation and promotes the healing of indomethacin-induced intestinal ulcers in rats. Dig Dis Sci. 59:1286–1295. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Iakoubov R, Lauffer LM, Trivedi S, Kim YI and Brubaker PL: Carcinogenic effects of exogenous and endogenous glucagon-like peptide-2 in azoxymethane-treated mice. Endocrinology. 150:4033–4043. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Lim JB and Chung HW: Serum ENA78/CXCL5, SDF-1/CXCL12, and their combinations as potential biomarkers for prediction of the presence and distant metastasis of primary gastric cancer. Cytokine. 73:16–22. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Johnson RL and Fleet JC: Animal models of colorectal cancer. Cancer Metastasis Rev. 32:39–61. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Yorifuji N, Inoue T, Iguchi M, Fujiwara K, Kakimoto K, Nouda S, Okada T, Kawakami K, Abe Y, Takeuchi T and Higuchi K: The dipeptidyl peptidase-4 inhibitor sitagliptin suppresses mouse colon tumorigenesis in type 2 diabetic mice. Oncol Rep. 35:676–682. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Sakanaka T, Inoue T, Yorifuji N, Iguchi M, Fujiwara K, Narabayashi K, Kakimoto K, Nouda S, Okada T, Kuramoto T, et al: The effects of a TGR5 agonist and a dipeptidyl peptidase IV inhibitor on dextran sulfate sodium-induced colitis in mice. J Gastroenterol Hepatol. 30:(Suppl 1). S60–S65. 2015. View Article : Google Scholar

24 

Chavey C and Fajas L: CXCL5 drives obesity to diabetes, and further. Aging (Albany NY). 1:674–677. 2009. View Article : Google Scholar : PubMed/NCBI

25 

Nunemaker CS, Chung HG, Verrilli GM, Corbin KL, Upadhye A and Sharma PR: Increased serum CXCL1 and CXCL5 are linked to obesity, hyperglycemia, and impaired islet function. J Endocrinol. 222:267–276. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Kim D, Kim J, Yoon JH, Ghim J, Yea K, Song P, Park S, Lee A, Hong CP, Jang MS, et al: CXCL12 secreted from adipose tissue recruits macrophages and induces insulin resistance in mice. Diabetologia. 57:1456–1465. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Blogowski W, Serwin K, Budkowska M, Salata D, Dolegowska B, Lokaj M, Prowans P and Starzynska T: Clinical analysis of systemic and adipose tissue levels of selected hormones/adipokines and stromal-derived factor-1. J Biol Regul Homeost Agents. 26:607–615. 2012.PubMed/NCBI

28 

Kitahara CM, Trabert B, Katki HA, Chaturvedi AK, Kemp TJ, Pinto LA, Moore SC, Purdue MP, Wentzensen N, Hildesheim A and Shiels MS: Body mass index, physical activity, and serum markers of inflammation, immunity, and insulin resistance. Cancer Epidemiol Biomarkers Prev. 23:2840–2849. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Yazbeck R, Howarth GS and Abbott CA: Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol Sci. 30:600–607. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Busso N, Wagtmann N, Herling C, Chobaz-Péclat V, Bischof-Delaloye A, So A and Grouzmann E: Circulating CD26 is negatively associated with inflammation in human and experimental arthritis. Am J Pathol. 166:433–442. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Nakagami H, Pang Z, Shimosato T, Moritani T, Kurinami H, Koriyama H, Tenma A, Shimamura M and Morishita R: The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome. Hypertens Res. 37:629–635. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Li CL, Zhao LJ, Zhou XL, Wu HX and Zhao JJ: Review on the effect of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors for the treatment of non-alcoholic fatty liver disease. J Huazhong Univ Sci Technolog Med Sci. 35:333–336. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wang JH, Inoue T, Higashiyama M, Guth PH, Engel E, Kaunitz JD and Akiba Y: Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther. 339:464–473. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Inoue T, Wang JH, Higashiyama M, Rudenkyy S, Higuchi K, Guth PH, Engel E, Kaunitz JD and Akiba Y: Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum. Am J Physiol Gastrointest Liver Physiol. 303:G810–G816. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Baldassano S, Amato A, Cappello F, Rappa F and Mulè F: Glucagon-like peptide-2 and mouse intestinal adaptation to a high-fat diet. J Endocrinol. 217:11–20. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fujiwara K, Inoue T, Henmi Y, Hirata Y, Naka Y, Hara A, Kakimoto K, Nouda S, Okada T, Kawakami K, Kawakami K, et al: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet. Oncol Lett 14: 4355-4360, 2017.
APA
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A. ... Higuchi, K. (2017). Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet. Oncology Letters, 14, 4355-4360. https://doi.org/10.3892/ol.2017.6698
MLA
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A., Kakimoto, K., Nouda, S., Okada, T., Kawakami, K., Takeuchi, T., Higuchi, K."Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet". Oncology Letters 14.4 (2017): 4355-4360.
Chicago
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A., Kakimoto, K., Nouda, S., Okada, T., Kawakami, K., Takeuchi, T., Higuchi, K."Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet". Oncology Letters 14, no. 4 (2017): 4355-4360. https://doi.org/10.3892/ol.2017.6698
Copy and paste a formatted citation
x
Spandidos Publications style
Fujiwara K, Inoue T, Henmi Y, Hirata Y, Naka Y, Hara A, Kakimoto K, Nouda S, Okada T, Kawakami K, Kawakami K, et al: Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet. Oncol Lett 14: 4355-4360, 2017.
APA
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A. ... Higuchi, K. (2017). Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet. Oncology Letters, 14, 4355-4360. https://doi.org/10.3892/ol.2017.6698
MLA
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A., Kakimoto, K., Nouda, S., Okada, T., Kawakami, K., Takeuchi, T., Higuchi, K."Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet". Oncology Letters 14.4 (2017): 4355-4360.
Chicago
Fujiwara, K., Inoue, T., Henmi, Y., Hirata, Y., Naka, Y., Hara, A., Kakimoto, K., Nouda, S., Okada, T., Kawakami, K., Takeuchi, T., Higuchi, K."Sitagliptin, a dipeptidyl peptidase-4 inhibitor, suppresses CXCL5 and SDF-1 and does not accelerate intestinal neoplasia formation in ApcMin/+ mice fed a high-fat diet". Oncology Letters 14, no. 4 (2017): 4355-4360. https://doi.org/10.3892/ol.2017.6698
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team