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Article Open Access

Metastatic gastric cancer from breast carcinoma: A report of 78 cases

  • Authors:
    • Liang Xu
    • Shujing Liang
    • Ningning Yan
    • Le Zhang
    • Hailiang Gu
    • Xiaochun Fei
    • Yingchun Xu
    • Fengchun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine, Suzhou, Jiangsu 215021, P.R. China, Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Pathology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China, Department of Oncology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4069-4077
    |
    Published online on: August 2, 2017
       https://doi.org/10.3892/ol.2017.6703
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Abstract

The metastatic spread of breast carcinoma to the stomach is rare. There are a small number of previous studies that report metastases from the breast to the stomach and these provide limited information regarding this infrequent event. Consequently, the clinicopathological features, clinical outcomes and the optimal treatment for these patients remain to be elucidated. In the present study, 78 cases of gastric metastases from breast cancer, including the current case, were identified from previous studies between 1960 and 2015. The clinicopathological features of primary breast tumors and metastatic gastric lesions, including initial stage, tumor size, hormone receptor status, treatment modalities and overall survival (OS) rate, were analyzed. The patients were all female and the median age at the time of gastric metastasis diagnosis was 59 years old (range, 38‑86 years). The majority of the patients initially presented with stage II breast cancer (35.9%) and abdominal pain was the most common symptom of gastric metastases (75.6%). A total of 51/78 patients (65.4%) were identified to have a history of invasive lobular breast carcinoma and the majority of gastric tumors were positive for hormonal receptors and human epidermal growth factor receptor 2 (HER‑2) negative (estrogen receptor, 94.0%; progesterone receptor, 68.3%; HER‑2, 5.9%). Furthermore, in the univariate analysis, multiple organs involved prior to or at the time of gastric metastases were diagnosed and multiple gastric lesions and peritoneal carcinomatosis were significantly correlated with OS. Additionally, salvage hormonal therapy, but not surgery or chemotherapy, significantly extended OS. However, in the multivariate analysis, metastasis prior to stomach involvement was the only independent indicator of poor OS. In conclusion, physicians must be vigilant when patients with breast cancer history present with gastrointestinal symptoms, despite gastric metastasis from breast cancer being rare. An appropriate systemic therapeutic strategy that includes hormonal therapy may be beneficial for this group of patients.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015: CA Cancer J Clin. 65:5–29. 2015.

2 

Wang H, Zhang C, Zhang J, Kong L, Zhu H and Yu J: The prognosis analysis of different metastasis pattern in patients with different breast cancer subtypes: A SEER based study. Oncotarget. Dec 27–2016.(Epub ahead of print). View Article : Google Scholar

3 

Koike K, Kitahara K, Higaki M, Urata M, Yamazaki F and Noshiro H: Clinicopathological features of gastric metastasis from breast cancer in three cases. Breast Cancer. 21:629–634. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Cheng L and Li X: Breast imaging reporting and datasystem (BI-RADS) of magnetics resonance imaging: Breast mass. Gland Surg. 1:62–74. 2012.PubMed/NCBI

5 

Bast RC Jr, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, Berkowitz RS, Leavitt T, Griffiths CT, Parker L, et al: A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med. 309:883–887. 1983. View Article : Google Scholar : PubMed/NCBI

6 

Singletary SE, Allred C, Ashley P, Bassett LW, Berry D, Bland KI, Borgen PI, Clark GM, Edge SB, Hayes DF, et al: Staging system for breast cancer: Revisions for the 6th edition of the AJCC cancer staging manual. Surg Clin North Am. 83:803–819. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Almubarak MM, Laé M, Cacheux W, de Cremoux P, Pierga JY, Reyal F, Bennett SP, Falcou MC, Salmon RJ, Baranger B and Mariani P: Gastric metastasis of breast cancer: A single centre retrospective study. Dig Liver Dis. 43:823–827. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Abid A, Moffa C and Monga DK: Breast cancer metastasis to the GI tract may mimic primary gastric cancer. J Clin Oncol. 31:e106–e107. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Taal BG, Boot H, van Heerde P, de Jong D, Hart AA and Burgers JM: Primary non-Hodgkin lymphoma of the stomach: Endoscopic pattern and prognosis in low versus high grade malignancy in relation to the MALT concept. Gut. 39:556–561. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Zelek L, Cottu PH, Mignot L, de Roquancourt A, Fizazi K, Cojean-Zelek I, Espie M and Marty M: Gastric metastases from breast cancer: A retrospective series of 12 patients. Am J Clin Oncol. 24:363–365. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Takeuchi H, Hiroshige S, Yoshikawa Y, Kusumoto T and Muto Y: A case of synchronous metastasis of breast cancer to stomach and colon. Anticancer Res. 32:4051–4055. 2012.PubMed/NCBI

12 

Taal BG, Peterse H and Boot H: Clinical presentation, endoscopic features and treatment of gastric metastases from breast carcinoma. Cancer. 89:2214–2221. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Kim GH, Ahn JY, Jung HY, Park YS, Kim MJ, Choi KD, Lee JH, Choi KS, do Kim H, Lim H, et al: Clinical and endoscopic features of metastatic tumors in the stomach. Gut Liver. 9:615–622. 2015.PubMed/NCBI

14 

Namikawa T and Hanazaki K: Clinicopathological features and treatment outcomes of metastatic tumors in the stomach. Surg Today. 44:1392–1399. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Van Trappen P, Serreyn R, Elewaut AE, Cocquyt V and Van Belle S: Abdominal pain with anorexia in patients with breast carcinoma. Ann Oncol. 9:1243–1245. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Schwarz RE, Klimstra DS and Turnbull AD: Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol. 93:111–114. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Borst MJ and Ingold JA: Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery. 114:637–642. 1993.PubMed/NCBI

18 

Arpino G, Bardou VJ, Clark GM and Elledge RM: Infiltrating lobular carcinoma of the breast: Tumor characteristics and clinical outcome. Breast Cancer Res. 6:R149–R156. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Sobinsky JD, Willson TD, Podbielski FJ and Connolly MM: Unusual metastatic patterns of invasive lobular carcinoma of the breast. Case Rep Oncol Med. 2013:9865172013.PubMed/NCBI

20 

Gruel N, Lucchesi C, Raynal V, Rodrigues MJ, Pierron G, Goudefroye R, Cottu P, Reyal F, Sastre-Garau X, Fourquet A, et al: Lobular invasive carcinoma of the breast is a molecular entity distinct from luminal invasive ductal carcinoma. Eur J Cancer. 46:2399–2407. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Fernandes GS, Corrêa TS, Carvalho EP, Katz A and Hoff PM: Gastric and endobronchial metastases in a case of lobular breast cancer. Case Rep Oncol. 6:555–560. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Arrangoiz R, Papavasiliou P, Dushkin H and Farma JM: Case report and literature review: Metastatic lobular carcinoma of the breast an unusual presentation. Int J Surg Case Rep. 2:301–305. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Bharat A, Gao F and Margenthaler JA: Tumor characteristics and patient outcomes are similar between invasive lobular and mixed invasive ductal/lobular breast cancers but differ from pure invasive ductal breast cancers. Am J Surg. 198:516–519. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Pectasides D, Psyrri A, Pliarchopoulou K, Floros T, Papaxoinis G, Skondra M, Papatsibas G, Macheras A, Athanasas G, Arapantoni-Datioti P and Economopoulos T: Gastric metastases originating from breast cancer: Report of 8 cases and review of the literature. Anticancer Res. 29:4759–4763. 2009.PubMed/NCBI

25 

Ricciuti B, Leonardi GC, Ravaioli N, De Giglio A, Brambilla M, Prosperi E, Ribacchi F, Meacci M, Crinò L, Maiettini D, et al: Ductal breast carcinoma metastatic to the stomach resembling primary linitis plastica in a male patient. J Breast Cancer. 19:324–329. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Yoshida Y: Metastases and primary neoplasms of the stomach in patients with breast cancer. Am J Surg. 125:738–743. 1973. View Article : Google Scholar : PubMed/NCBI

27 

Sataloff DM, Dentchev D, Henry DH and Weese JL: Isolated breast metastases from primary gastric adenocarcinoma. Breast J. 6:622000. View Article : Google Scholar : PubMed/NCBI

28 

Sato T, Muto I, Fushiki M, Hasegawa M, Hasegawa M, Sakai T and Sekiya M: Metastatic breast cancer from gastric and ovarian cancer, mimicking inflammatory breast cancer: Report of two cases. Breast Cancer. 15:315–320. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Sarkut P, Ozer A, Gulcu B, Ozturk E, Gokgoz S and Ugras N: An extremely rare cause of gastric outlet: Breast lobular carcinoma metastases to stomach. Breast J. 20:312–313. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Tot T: The role of cytokeratins 20 and 7 and estrogen receptor analysis in separation of metastatic lobular carcinoma of the breast and metastatic signet ring cell carcinoma of the gastrointestinal tract. APMIS. 108:467–472. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Martin V, Cappuzzo F, Mazzucchelli L and Frattini M: HER2 in solid tumors: More than 10 years under the microscope; where are we now? Future Oncol. 10:1469–1486. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Brown RW, Campagna LB, Dunn JK and Cagle PT: Immunohistochemical identification of tumor markers in metastatic adenocarcinoma. A diagnostic adjunct in the determination of primary site. Am J Clin Pathol. 107:12–19. 1997. View Article : Google Scholar : PubMed/NCBI

33 

Guarneri V, Giovannelli S, Ficarra G, Bettelli S, Maiorana A, Piacentini F, Barbieri E, Dieci MV, D'Amico R, Jovic G and Conte P: Comparison of HER-2 and hormone receptor expression in primary breast cancers and asynchronous paired metastases: Impact on patient management. Oncologist. 13:838–844. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Dassen AE, Lips DJ, Hoekstra CJ, Pruijt JF and Bosscha K: FDG-PET has no definite role in preoperative imaging in gastric cancer. Eur J Surg Oncol. 35:449–455. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Gadde R, Tamariz L, Hanna M, Avisar E, Livingstone A, Franceschi D and Yakoub D: Metastatic gastric cancer (MGC) patients: Can we improve survival by metastasectomy? A systematic review and meta-analysis. J Surg Oncol. 112:38–45. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wasif N, Maggard MA, Ko CY and Giuliano AE: Invasive lobular vs. ductal breast cancer: A stage-matched comparison of outcomes. Ann Surg Oncol. 17:1862–1869. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Ambroggi M, Stroppa EM, Mordenti P, Biasini C, Zangrandi A, Michieletti E, Belloni E and Cavanna L: Metastatic breast cancer to the gastrointestinal tract: Report of five cases and review of the literature. Int J Breast Cancer. 2012:4390232012. View Article : Google Scholar : PubMed/NCBI

38 

Spackman E, Rice S, Norman G, Suh DC, Eastwood A and Palmer S: Trastuzumab for the treatment of HER2-positive metastatic gastric cancer: A NICE single technology appraisal. Pharmacoeconomics. 31:185–194. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Liang S, Yan N, Zhang L, Gu H, Fei X, Xu Y and Zhang F: Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncol Lett 14: 4069-4077, 2017.
APA
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X. ... Zhang, F. (2017). Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncology Letters, 14, 4069-4077. https://doi.org/10.3892/ol.2017.6703
MLA
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X., Xu, Y., Zhang, F."Metastatic gastric cancer from breast carcinoma: A report of 78 cases". Oncology Letters 14.4 (2017): 4069-4077.
Chicago
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X., Xu, Y., Zhang, F."Metastatic gastric cancer from breast carcinoma: A report of 78 cases". Oncology Letters 14, no. 4 (2017): 4069-4077. https://doi.org/10.3892/ol.2017.6703
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Liang S, Yan N, Zhang L, Gu H, Fei X, Xu Y and Zhang F: Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncol Lett 14: 4069-4077, 2017.
APA
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X. ... Zhang, F. (2017). Metastatic gastric cancer from breast carcinoma: A report of 78 cases. Oncology Letters, 14, 4069-4077. https://doi.org/10.3892/ol.2017.6703
MLA
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X., Xu, Y., Zhang, F."Metastatic gastric cancer from breast carcinoma: A report of 78 cases". Oncology Letters 14.4 (2017): 4069-4077.
Chicago
Xu, L., Liang, S., Yan, N., Zhang, L., Gu, H., Fei, X., Xu, Y., Zhang, F."Metastatic gastric cancer from breast carcinoma: A report of 78 cases". Oncology Letters 14, no. 4 (2017): 4069-4077. https://doi.org/10.3892/ol.2017.6703
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