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Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature

  • Authors:
    • Lauge Hjorth Mikkelsen
    • Simon Andreasen
    • Linea Cecilie Melchior
    • Marta Persson
    • Jeppe Dyrberg Andersen
    • Vania Pereira
    • Peter Bjerre Toft
    • Niels Morling
    • Göran Stenman
    • Steffen Heegaard
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark, Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, 4600 Køge, Denmark, Department of Pathology and Genetics, Sahlgrenska Cancer Center, University of Gothenburg, 40530 Gothenburg, Sweden, Section of Forensic Genetics, Department of Forensic Medicine, University of Copenhagen, 2100 Copenhagen, Denmark, Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital, 2100 Copenhagen, Denmark
    Copyright: © Mikkelsen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4176-4182
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/ol.2017.6713
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Abstract

The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213‑UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array‑based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified in oncocytoma and may be specific to lacrimal gland oncocytoma. Sequencing of the mitochondrial genome demonstrated multiple alterations of the NADH‑ubiquinone oxidoreductase chain 5 (ND5) gene involved in mitochondrial oxidative phosphorylation. This may support the notion of a common genetic background of oncocytic lesions in the lacrimal gland and other anatomical sites.
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1 

Østergaard J, Prause JU and Heegaard S: Oncocytic lesions of the ophthalmic region: A clinicopathological study with emphasis on cytokeratin expression. Acta Ophthalmol. 89:263–267. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Máximo V, Rios E and Sobrinho-Simoes M: Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex and parathyroid glands. Int J Surg Pathol. 22:33–36. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK and Heegaard S: An update on tumors of the lacrimal gland. Asia Pac J Ophthalmol (Phila). 6:159–172. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Gasparre G, Bonora E, Tallini G and Romeo G: Molecular features of thyroid oncocytic tumors. Mol Cell Endocrinol. 321:67–76. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Beskid M and Zarzycka M: A case of onkocytoma of the lacrimal gland. Klin Oczna. 29:311–315. 1959.(In Polish). PubMed/NCBI

6 

Riedel K, Stefani FH and Kampik A: Oncocytoma of the ocular adnexa. Klin Monatsbl Augenheilkd. 182:544–548. 1983.(In German). View Article : Google Scholar : PubMed/NCBI

7 

Hartman LJ, Mourits MP and Canninga-van Dijk MR: An unusual tumour of the lacrimal gland. Br J Ophthalmol. 87:3632003. View Article : Google Scholar : PubMed/NCBI

8 

Calle CA, Castillo IG, Eagle RC and Daza MT: Oncocytoma of the lacrimal gland: Case report and review of the literature. Orbit. 25:243–247. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Archondakis S, Skagias L, Tsakiris A, Sambaziotis D and Daskalopoulou D: Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology. Diagn Cytopathol. 37:443–445. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Economou M, Seregard S and Sahlin S: Oncocytoma of the lacrimal gland. Acta Ophthalmologica. 85:576–577. 2007. View Article : Google Scholar

11 

Kim JY, Park HY, Paik JS, Kim DC and Yang SW: Oncocytoma of the lacrimal gland: An Asian case. Jpn J Ophthalmol. 54:239–241. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Aghaji AE, Olushina DB and Okoye OI: Oxyphil cell adenoma in a Nigerian: Case report and review of the literature. Niger J Clin Pract. 14:373–376. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Limb RJ, Rosenfeld JV and McLean C: Giant orbital oncocytoma. Asian J Neurosurg. 8:192–194. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ferte A, Trechot F, Cloche V, Busby H, Maalouf T, Angioi K and George JL: Oncocytoma: An uncommon lesion of the lacrimal gland. J Fr Ophtalmol. 39:e231–e233. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Jittapiromsak N, Hou P, Williams MD and Chi TL: Orbital oncocytoma: Evaluation with dynamic contrast-enhanced magnetic resonance imaging using a time-signal intensity curve and positive enhancement integral images. Clin Imaging. 42:161–164. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Joshi S, Tolkunov D, Aviv H, Hakimi AA, Yao M, Hsieh JJ, Ganesan S, Chan CS and White E: The genomic landscape of renal oncocytoma identifies a metabolic barrier to tumorigenesis. Cell Rep. 13:1895–1908. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Gasparre G, Porcelli AM, Bonora E, Pennisi LF, Toller M, Iommarini L, Ghelli A, Moretti M, Betts CM, Martinelli GN, et al: Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Proc Natl Acad Sci USA. 104:9001–9006. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Maximo V, Lima J, Soares P, Botelho T, Gomes L and Sobrinho-Simões M: Mitochondrial D-loop instability in thyroid tumours is not a marker of malignancy. Mitochondrion. 5:333–340. 2005. View Article : Google Scholar : PubMed/NCBI

19 

World Medical Association, . World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Andreasen S, Persson M, Kiss K, Homøe P, Heegaard S and Stenman G: Genomic profiling of a combined large cell neuroendocrine carcinoma of the submandibular gland. Oncol Rep. 35:2177–2182. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Persson F, Winnes M, Andrén Y, Wedell B, Dahlenfors R, Asp J, Mark J, Enlund F and Stenman G: High-resolution array CGH analysis of salivary gland tumors reveals fusion and amplification of the FGFR1 and PLAG1 genes in ring chromosomes. Oncogene. 27:3072–3080. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lott MT, Leipzig JN, Derbeneva O, Xie HM, Chalkia D, Sarmady M, Procaccio V and Wallace DC: mtDNA variation and analysis using mitomap and mitomaster. Curr Protoc Bioinformatics. 44:1.23–1.16. 2013.

23 

Castellana S, Rónai J and Mazza T: MitImpact: An exhaustive collection of pre-computed pathogenicity predictions of human mitochondrial non-synonymous variants. Hum Mutat. 36:E2413–E2422. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Adzhubei I, Jordan DM and Sunyaev SR: Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet: Chapter 7. Unit 7.20. 2013. View Article : Google Scholar

25 

Mark J, Dahlenfors R, Havel G and Böckmann P: Benign parotid oncocytoma with the chromosomal abnormality trisomy 7. Anticancer Res. 11:1735–1737. 1991.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Mikkelsen LH, Andreasen S, Melchior LC, Persson M, Andersen JD, Pereira V, Toft PB, Morling N, Stenman G, Heegaard S, Heegaard S, et al: Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. Oncol Lett 14: 4176-4182, 2017.
APA
Mikkelsen, L.H., Andreasen, S., Melchior, L.C., Persson, M., Andersen, J.D., Pereira, V. ... Heegaard, S. (2017). Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. Oncology Letters, 14, 4176-4182. https://doi.org/10.3892/ol.2017.6713
MLA
Mikkelsen, L. H., Andreasen, S., Melchior, L. C., Persson, M., Andersen, J. D., Pereira, V., Toft, P. B., Morling, N., Stenman, G., Heegaard, S."Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature". Oncology Letters 14.4 (2017): 4176-4182.
Chicago
Mikkelsen, L. H., Andreasen, S., Melchior, L. C., Persson, M., Andersen, J. D., Pereira, V., Toft, P. B., Morling, N., Stenman, G., Heegaard, S."Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature". Oncology Letters 14, no. 4 (2017): 4176-4182. https://doi.org/10.3892/ol.2017.6713
Copy and paste a formatted citation
x
Spandidos Publications style
Mikkelsen LH, Andreasen S, Melchior LC, Persson M, Andersen JD, Pereira V, Toft PB, Morling N, Stenman G, Heegaard S, Heegaard S, et al: Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. Oncol Lett 14: 4176-4182, 2017.
APA
Mikkelsen, L.H., Andreasen, S., Melchior, L.C., Persson, M., Andersen, J.D., Pereira, V. ... Heegaard, S. (2017). Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature. Oncology Letters, 14, 4176-4182. https://doi.org/10.3892/ol.2017.6713
MLA
Mikkelsen, L. H., Andreasen, S., Melchior, L. C., Persson, M., Andersen, J. D., Pereira, V., Toft, P. B., Morling, N., Stenman, G., Heegaard, S."Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature". Oncology Letters 14.4 (2017): 4176-4182.
Chicago
Mikkelsen, L. H., Andreasen, S., Melchior, L. C., Persson, M., Andersen, J. D., Pereira, V., Toft, P. B., Morling, N., Stenman, G., Heegaard, S."Genomic and immunohistochemical characterisation of a lacrimal gland oncocytoma and review of literature". Oncology Letters 14, no. 4 (2017): 4176-4182. https://doi.org/10.3892/ol.2017.6713
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