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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer

  • Authors:
    • Changcai Teng
    • Hong Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China
  • Pages: 4277-4281
    |
    Published online on: August 3, 2017
       https://doi.org/10.3892/ol.2017.6714
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Abstract

MicroRNAs (miRs) serve important roles in cancer genesis and progression. The expression of miR‑1908 has been reported in a number of types of cancer; however, the clinical significance of miR‑1908 in human ovarian cancer (OC) remains unclear. A total of 491 patients with OC from The Cancer Genome Atlas project cohort were selected and divided into two groups according to the median expression level of miR‑1908. Univariate and multivariate analyses, using the Kaplan‑Meier method and Cox regression, were performed to identify the characteristics that predict OC prognosis. Bioinformatics tools were used to identify potential targets of miR‑1908. It was identified that the low expression of miR‑1908 is associated with a poor prognosis for OC (P<0.05). The potential target genes of miR‑1908 included podocan‑like 1, JunB AP‑1 transcription factor subunit, homeobox B8, SET binding factor 1 and sirtuin 2; high expression of these five genes additionally predicted a poor prognosis. These results suggest that miR‑1908 may be a suitable target for the development of novel approaches in OC diagnosis and therapy in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Teng C and Zheng H: Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncol Lett 14: 4277-4281, 2017.
APA
Teng, C., & Zheng, H. (2017). Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncology Letters, 14, 4277-4281. https://doi.org/10.3892/ol.2017.6714
MLA
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14.4 (2017): 4277-4281.
Chicago
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14, no. 4 (2017): 4277-4281. https://doi.org/10.3892/ol.2017.6714
Copy and paste a formatted citation
x
Spandidos Publications style
Teng C and Zheng H: Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncol Lett 14: 4277-4281, 2017.
APA
Teng, C., & Zheng, H. (2017). Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer. Oncology Letters, 14, 4277-4281. https://doi.org/10.3892/ol.2017.6714
MLA
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14.4 (2017): 4277-4281.
Chicago
Teng, C., Zheng, H."Low expression of microRNA‑1908 predicts a poor prognosis for patients with ovarian cancer". Oncology Letters 14, no. 4 (2017): 4277-4281. https://doi.org/10.3892/ol.2017.6714
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