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Mechanisms of CXCR7 induction in malignant melanoma development

  • Authors:
    • Xiao‑Jing Li
    • Pai Liu
    • Wei‑Wei Tian
    • Zhi‑Feng Li
    • Bao‑Guo Liu
    • Jian‑Fang Sun
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. China, Department of Dermatology, Jiangxi Province Dermatosis Special Hospital, Nanchang, Jiangxi 330000, P.R. China, Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, Jiangsu 210042, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4106-4114
    |
    Published online on: August 4, 2017
       https://doi.org/10.3892/ol.2017.6720
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Abstract

Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C‑X‑C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development. First, CXCR7 expression levels were assessed in the skin tumor tissue of patients with MM. Then, CXCR7 small hairpin RNA was used in M14 melanoma cells in a Transwell culture model and in a transplanted mouse model to test the effects of CXCR7. In addition, immunohistochemistry staining, reverse transcription‑quantitative polymerase chain reaction and western blotting were used. The results revealed that CXCR7 expression levels were significantly higher in MM tissue compared with squamous cell carcinoma or basal cell carcinoma tissue. Knocking down CXCR7 in M14 cells significantly inhibited cell migration and invasion in the Transwell culture model. Furthermore, CXCR7 knockdown also significantly reduced the transplanted tumor size, weight and vascular number in the mouse model. It was concluded that CXCR7 interacts with C‑X‑C motif chemokine ligand 12 to activate the chemokine receptor signaling pathway, and to increase melanoma cell migration, invasion and development.
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1 

Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, Cascinelli N, Urist M, McMasters KM, Ross MI, Kirkwood JM, et al: Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 19:3622–3634. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Balch CM, Soong SJ, Smith T, Ross MI, Urist MM, Karakousis CP, Temple WJ, Mihm MC, Barnhill RL, Jewell WR, et al: Long-term results of a prospective surgical trial comparing 2 cm vs. 4 cm excision margins for 740 patients with 1–4 mm melanomas. Ann Surg Oncol. 8:101–108. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Slominski A, Wortsman J, Carlson AJ, Matsuoka LY, Balch CM and Mihm MC: Malignant melanoma. Arch Pathol Lab Med. 125:1295–1306. 2001.PubMed/NCBI

4 

Balch CM, Buzaid AC, Soong SJ, Atkins MB, Cascinelli N, Coit DG, Fleming ID, Gershenwald JE, Houghton A Jr, Kirkwood JM, et al: Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma. J Clin Oncol. 19:3635–3648. 2001. View Article : Google Scholar : PubMed/NCBI

5 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK, Foshag LJ and Cochran AJ: Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg. 127:392–399. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Baggiolini M and Loetscher P: Chemokines in inflammation and immunity. Immunol Today. 21:418–420. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Balkwill F: Cancer and the chemokine network. Nat Rev Cancer. 4:540–550. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Rossi D and Zlotnik A: The biology of chemokines and their receptors. Annu Rev Immunol. 18:217–242. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Sánchez-Martin L, Sánchez-Mateos P and Cabañas C: CXCR7 impact on CXCL12 biology and disease. Trends Mol Med. 19:12–22. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Beutner KR, Geisse JK, Helman D, Fox TL, Ginkel A and Owens ML: Therapeutic response of basal cell carcinoma to the immune response modifier imiquimod 5% cream. J Am Acad Dermatol. 41:1002–1007. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Rowe DE, Carroll RJ and Day CL Jr: Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. Implications for treatment modality selection. J Am Acad Dermatol. 26:976–990. 1992. View Article : Google Scholar : PubMed/NCBI

13 

Shaw LM: Tumor cell invasion assays. Methods Mol Biol. 294:97–105. 2005.PubMed/NCBI

14 

Yang FC, Atkinson SJ, Gu Y, Borneo JB, Roberts AW, Zheng Y, Pennington J and Williams DA: Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization. Proc Natl Acad Sci USA. 98:5614–5618. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Tsareva SA, Moriggl R, Corvinus FM, Wiederanders B, Schütz A, Kovacic B and Friedrich K: Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia. 9:279–291. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Giard DJ, Aaronson SA, Todaro GJ, Arnstein P, Kersey JH, Dosik H and Parks WP: In vitro cultivation of human tumors: Establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst. 51:1417–1423. 1973. View Article : Google Scholar : PubMed/NCBI

17 

Sulit HL, Golub SH, Irie RF, Gupta RK, Grooms GA and Morton DL: Human tumor cells grown in fetal calf serum and human serum: Influences on the tests for lymphocyte cytotoxicity, serum blocking and serum arming effects. Int J Cancer. 17:461–468. 1976. View Article : Google Scholar : PubMed/NCBI

18 

Larionov A, Krause A and Miller W: A standard curve based method for relative real time PCR data processing. BMC Bioinformatics. 6:622005. View Article : Google Scholar : PubMed/NCBI

19 

Sun X, Cheng G, Hao M, Zheng J, Zhou X, Zhang J, Taichman RS, Pienta KJ and Wang J: CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 29:709–722. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Wang J, Shiozawa Y, Wang J, Wang Y, Jung Y, Pienta KJ, Mehra R, Loberg R and Taichman RS: The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J Biol Chem. 283:4283–4294. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Huggenberger R and Detmar M: The cutaneous vascular system in chronic skin inflammation. J Investig Dermatol Symp Proc. 15:24–32. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Tarnowski M, Liu R, Wysoczynski M, Ratajczak J, Kucia M and Ratajczak MZ: CXCR7: A new SDF-1-binding receptor in contrast to normal CD34(+) progenitors is functional and is expressed at higher level in human malignant hematopoietic cells. Eur J Haematol. 85:472–483. 2010. View Article : Google Scholar : PubMed/NCBI

23 

D'Alterio C, Consales C, Polimeno M, Franco R, Cindolo L, Portella L, Cioffi M, Calemma R, Marra L, Claudio L, et al: Concomitant CXCR4 and CXCR7 expression predicts poor prognosis in renal cancer. Curr Cancer Drug Targets. 10:772–781. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Pinto S, Martinez-Romero A, O'Connor JE, Gil-Benso R, San-Miguel T, Terrádez L, Monteagudo C and Callaghan RC: Intracellular coexpression of CXC- and CC-chemokine receptors and their ligands in human melanoma cell lines and dynamic variations after xenotransplantation. BMC Cancer. 14:1182014. View Article : Google Scholar : PubMed/NCBI

25 

Richmond A, Yang J and Su Y: The good and the bad of chemokines/chemokine receptors in melanoma. Pigment Cell Melanoma Res. 22:175–186. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Longo-Imedio MI, Longo N, Treviño I, Lázaro P and Sánchez-Mateos P: Clinical significance of CXCR3 and CXCR4 expression in primary melanoma. Int J Cancer. 117:861–865. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Monteagudo C, Martin JM, Jorda E and Llombart-Bosch A: CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: Correlation with clinicopathological prognostic factors. J Clin Pathol. 60:596–599. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Levoye A, Balabanian K, Baleux F, Bachelerie F and Lagane B: CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood. 113:6085–6093. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Lee E, Han J, Kim K, Choi H, Cho EG and Lee TR: CXCR7 mediates SDF1-induced melanocyte migration. Pigment Cell Melanoma Res. 26:58–66. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Sierro F, Biben C, Martinez-Muñoz L, Mellado M, Ransohoff RM, Li M, Woehl B, Leung H, Groom J, Batten M, et al: Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc Natl Acad Sci USA. 104:14759–14764. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Salazar N, Muñoz D, Kallifatidis G, Singh RK, Jordà M and Lokeshwar BL: The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Mol Cancer. 13:1982014. View Article : Google Scholar : PubMed/NCBI

32 

Singh RK and Lokeshwar BL: The IL-8-regulated chemokine receptor CXCR7 stimulates EGFR signaling to promote prostate cancer growth. Cancer Res. 71:3268–3277. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li XJ, Liu P, Tian WW, Li ZF, Liu BG and Sun JF: Mechanisms of CXCR7 induction in malignant melanoma development. Oncol Lett 14: 4106-4114, 2017.
APA
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., & Sun, J. (2017). Mechanisms of CXCR7 induction in malignant melanoma development. Oncology Letters, 14, 4106-4114. https://doi.org/10.3892/ol.2017.6720
MLA
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., Sun, J."Mechanisms of CXCR7 induction in malignant melanoma development". Oncology Letters 14.4 (2017): 4106-4114.
Chicago
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., Sun, J."Mechanisms of CXCR7 induction in malignant melanoma development". Oncology Letters 14, no. 4 (2017): 4106-4114. https://doi.org/10.3892/ol.2017.6720
Copy and paste a formatted citation
x
Spandidos Publications style
Li XJ, Liu P, Tian WW, Li ZF, Liu BG and Sun JF: Mechanisms of CXCR7 induction in malignant melanoma development. Oncol Lett 14: 4106-4114, 2017.
APA
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., & Sun, J. (2017). Mechanisms of CXCR7 induction in malignant melanoma development. Oncology Letters, 14, 4106-4114. https://doi.org/10.3892/ol.2017.6720
MLA
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., Sun, J."Mechanisms of CXCR7 induction in malignant melanoma development". Oncology Letters 14.4 (2017): 4106-4114.
Chicago
Li, X., Liu, P., Tian, W., Li, Z., Liu, B., Sun, J."Mechanisms of CXCR7 induction in malignant melanoma development". Oncology Letters 14, no. 4 (2017): 4106-4114. https://doi.org/10.3892/ol.2017.6720
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