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Article

Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma

  • Authors:
    • Hong Chen
    • Zhi‑Qiang Zhang
    • Bin Zhao
    • Wen‑Long Ning
    • Xue‑Yan Wang
    • Fei Zhou
  • View Affiliations / Copyright

    Affiliations: Center of Individualized Medicine Diagnosis and Treatment, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China, Department of First General Surgery, The First Hospital of Harbin, Harbin, Heilongjiang 150010, P.R. China, Department of Anorectal Surgery, The First Hospital Affiliated of Jiamusi University, Jiamusi, Heilongjiang 154000, P.R. China, Department of Emergency, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China, Department of Public Health, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China, Department of Second General Surgery, The First Hospital of Qiqihar, Qiqihar, Heilongjiang 161005, P.R. China
  • Pages: 4878-4882
    |
    Published online on: August 10, 2017
       https://doi.org/10.3892/ol.2017.6743
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Abstract

Esophageal carcinoma is the most common type of tumor, with the incidence in China accounting for 50% of cases worldwide and the majority of patients not surviving due to tumor recurrence. According to the cancer stem cell theory, tumor development and recurrence is due to the excitation of a cancer stem cell. Aldehyde dehydrogenase 1 (ALDH1) is an appropriate marker for cancer stem cells and the present study aimed at determining the function of ALDH1 in human esophageal carcinoma. Indirect fluorescence antibody staining was used to investigate the association between the level of ALDH1 protein expression and clinicopathological parameters, including sex, age, vein invasion, degree of tumor cell differentiation and clinical stage. DAPI was used to stain the nuclei of tumor cells and exclude non‑tumor cells. The results of the present study revealed that ALDH1 expression was associated with the level of tumor cell differentiation, tumor‑node‑metastasis stage and lymphatic invasion. In addition, increased expression of ALDH1 was identified in esophageal carcinoma tissues compared with in healthy esophageal tissues. Therefore, ALDH1 may be used as a parameter for the pathology of esophageal carcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Chen H, Zhang ZQ, Zhao B, Ning WL, Wang XY and Zhou F: Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma. Oncol Lett 14: 4878-4882, 2017.
APA
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., & Zhou, F. (2017). Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma. Oncology Letters, 14, 4878-4882. https://doi.org/10.3892/ol.2017.6743
MLA
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., Zhou, F."Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma". Oncology Letters 14.4 (2017): 4878-4882.
Chicago
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., Zhou, F."Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma". Oncology Letters 14, no. 4 (2017): 4878-4882. https://doi.org/10.3892/ol.2017.6743
Copy and paste a formatted citation
x
Spandidos Publications style
Chen H, Zhang ZQ, Zhao B, Ning WL, Wang XY and Zhou F: Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma. Oncol Lett 14: 4878-4882, 2017.
APA
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., & Zhou, F. (2017). Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma. Oncology Letters, 14, 4878-4882. https://doi.org/10.3892/ol.2017.6743
MLA
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., Zhou, F."Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma". Oncology Letters 14.4 (2017): 4878-4882.
Chicago
Chen, H., Zhang, Z., Zhao, B., Ning, W., Wang, X., Zhou, F."Clinical significance of ALDH1 combined with DAPI expression in patients with esophageal carcinoma". Oncology Letters 14, no. 4 (2017): 4878-4882. https://doi.org/10.3892/ol.2017.6743
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