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Article

Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist

  • Authors:
    • Xiaohong Sun
    • Yu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, Nanhua Hospital Affiliated to Nanhua University, Hengyang, Hunan 421001, P.R. China
  • Pages: 4841-4844
    |
    Published online on: August 14, 2017
       https://doi.org/10.3892/ol.2017.6754
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Abstract

The Wnt signaling pathway regulates a number of biological processes. In the present study, the association between the Wnt signaling pathway and the pathogenesis of cervical cancer was investigated in the human cervical cancer CaSki cell line. An MTT assay was used to screen various concentrations of lithium chloride for use in subsequent experiments. Following incubation of CaSki cells with 0.05 and 0.1 mol/l lithium chloride, Twist and β‑catenin were markedly upregulated at the mRNA and protein levels, respectively, compared with the untreated group, as measured by reverse transcription‑polymerase chain reaction and western blotting. The results of the present study indicate that Wnt activation (which was induced by lithium chloride) and the subsequent upregulation of Twist may represent one of the molecular mechanisms underlying the occurrence and development of cervical cancer.
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1 

Parkin DM and Bray F: Chapter 2: The burden of HPV-related cancers. Vaccine. 24 Suppl 3:S3/11–25. 2006. View Article : Google Scholar

2 

Parkin DM, Bray F, Ferlay J and Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer. 94:153–156. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Uren A, Fallen S, Yuan H, Usubutun A, Kücükali T, Schlegel R and Toretsky JA: Activation of the canonical Wnt pathway during genital keratinocyte transformation: A model for cervical cancer progression. Cancer Res. 65:6199–6206. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Perez-Plasencia C, Duenas-Gonzalez A and Alatorre-Tavera B: Second hit in cervical carcinogenesis process: Involvement of wnt/beta catenin pathway. Int Arch Med. 1:102008. View Article : Google Scholar : PubMed/NCBI

5 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms, and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Xufeng Z, Liang Y and Yi L: Wnt/β-catenin signaling pathway and its role in hepatocellular carcinoma. Front Med China. 2:216–228. 2008. View Article : Google Scholar

7 

Tan Z, Zheng H, Lin X, Zhang W, Zhu J, Wu G, Cao L, Song J, Wu S, Song L and Li J: MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/β-catenin signaling in breast cancer. Oncotarget. 7:24076–24087. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Chikazawa N, Tanaka H, Tasaka T, Nakamura M, Tanaka M, Onishi H and Katano M: Inhibition of Wnt signaling pathway decreases chemotherapy-resistant side-population colon cancer cells. Anticancer Res. 30:2041–2048. 2010.PubMed/NCBI

9 

Shinohara A, Yokoyama Y, Wan X, Takahashi Y, Mori Y, Takami T, Shimokawa K and Tamaya T: Cytoplasmic/nuclear expression without mutation of exon 3 of the beta-catenin gene is frequent in the development of the neoplasm of the uterine cervix. Gynecol Oncol. 82:450–455. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A and Weinberg RA: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 117:927–939. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Bastid J, Ciancia C, Puisieux A and Ansieau S: Role of TWIST proteins in cancer progression. Atlas Genet Cytogenet Oncol Haematol. 14:898–944. 2010.

12 

Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L and Xu J: The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 21:275–289. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Hiyama A, Sakai D, Arai F, Nakajima D, Yokoyama K and Mochida J: Effects of a glycogen synthase kinase-3β inhibitor (LiCl) on c-myc protein in intervertebral disc cells. J Cell Biochem. 112:2974–2986. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Benary U, Kofahl B, Hecht A and Wolf J: Modeling Wnt/β-catenin target gene expression in APC and Wnt gradients under wild type and mutant conditions. Front Physiol. 4:212013. View Article : Google Scholar : PubMed/NCBI

15 

Bahrami A, Hasanzadeh M, ShahidSales S, Yousefi Z, Kadkhodayan S, Farazestanian M, Mashhad Joudi M, Gharib M, Hassanian SM and Avan A: Clinical significance and prognosis value of Wnt signaling pathway in cervical cancer. J Cell Biochem. Mar 16–2017.(Epub ahead of print). doi: 10.1002/jcb.25992. View Article : Google Scholar

16 

Wang F, Huang W, Hu X, Chen C, Li X, Qiu J, Liang Z, Zhang J, Li L, Wang X, et al: Transcription factor AP-2β suppresses cervical cancer cell proliferation by promoting the degradation of its interaction partner β-catenin. Mol Carcinog. 56:1909–1923. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Ormanns S, Neumann J, Horst D, Kirchner T and Jung A: WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-catenin depend on active PI3K signaling. Oncotarget. 5:2999–3011. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ying Y and Tao Q: Epigenetic disruption of the WNT/beta-catenin signaling pathway in human cancers. Epigenetics. 4:307–312. 2009. View Article : Google Scholar

19 

Klein PS and Melton DA: A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci USA. 93:8455–8459. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Fadare O, Reddy H, Wang J, Hileeto D, Schwartz PE and Zheng W: E-cadherin and beta-catenin expression in early stage cervical carcinoma: A tissue microarray study of 147 cases. World J Surg Oncol. 3:382005. View Article : Google Scholar : PubMed/NCBI

21 

Yang L, Hou Y, Yuan J, Tang S, Zhang H, Zhu Q, Du YE, Zhou M, Wen S, Xu L, et al: Twist promotes reprogramming of glucose metabolism in breast cancer cells through PI3K/AKT and p53 signaling pathways. Oncotarget. 6:25755–25769. 2015. View Article : Google Scholar : PubMed/NCBI

22 

DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S and Kuperwasser C: A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transitionin basal-like breast cancer. Cancer Res. 69:5364–5373. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun X and Liu Y: Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist. Oncol Lett 14: 4841-4844, 2017.
APA
Sun, X., & Liu, Y. (2017). Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist. Oncology Letters, 14, 4841-4844. https://doi.org/10.3892/ol.2017.6754
MLA
Sun, X., Liu, Y."Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist". Oncology Letters 14.4 (2017): 4841-4844.
Chicago
Sun, X., Liu, Y."Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist". Oncology Letters 14, no. 4 (2017): 4841-4844. https://doi.org/10.3892/ol.2017.6754
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X and Liu Y: Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist. Oncol Lett 14: 4841-4844, 2017.
APA
Sun, X., & Liu, Y. (2017). Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist. Oncology Letters, 14, 4841-4844. https://doi.org/10.3892/ol.2017.6754
MLA
Sun, X., Liu, Y."Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist". Oncology Letters 14.4 (2017): 4841-4844.
Chicago
Sun, X., Liu, Y."Activation of the Wnt/β-catenin signaling pathway may contribute to cervical cancer pathogenesis via upregulation of Twist". Oncology Letters 14, no. 4 (2017): 4841-4844. https://doi.org/10.3892/ol.2017.6754
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