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Article

Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle

  • Authors:
    • Changjiang Yin
    • Xiaoxia Qi
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Shandong Traffic Hospital, Jinan, Shandong 250031, P.R. China, Department of Obstetrics and Gynecology, Maternal and Child Health Care of Shandong, Jinan, Shandong 250031, P.R. China
  • Pages: 4873-4877
    |
    Published online on: August 16, 2017
       https://doi.org/10.3892/ol.2017.6756
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Abstract

Pituitary tumors may secrete hormones that affect pregnancy. Pregnancy also induces pituitary tumor growth; however, how pregnancy increases the growth of pituitary tumors remains unclear. The present study investigated pregnant female mice with subcutaneous pituitary tumors. The time of tumor occurrence and tumor weight were detected in pregnant and control mice. Tumor weights were measured at the end of the experiment. Blood was collected from pregnant and control mice. Brain‑derived neurotrophic factor (BDNF) levels in the blood were detected using an ELISA kit. The in vitro effects of BDNF on pituitary tumor AtT‑20 cell proliferation and cell cycle were investigated. It was revealed that pregnancy promoted the growth of pituitary tumors. In comparison to non‑pregnant mice, the pregnant mice exhibited increased BDNF levels in the blood. In vitro BDNF treatment was able to increase the rate of proliferation of pituitary tumor cells. Additional cell cycle analysis revealed that BDNF was able to alter the cell cycle distribution of pituitary tumor cells. These results indicated that pregnancy was able to increase the BDNF level and promote the growth of pituitary tumor cells by increasing the rate of the cell cycle, leading to increased tumor growth rate in vivo. The present study provides insights into how pregnancy affects the growth of pituitary tumors. Therefore, it may be beneficial to perform pituitary tumor diagnosis or therapy on pregnant patients.
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1 

Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML and McCutcheon IE: ‘The prevalence of pituitary adenomas’: A systematic review. Cancer. 101:613–619. 2004. View Article : Google Scholar

2 

Karavitaki N: Prevalence and incidence of pituitary adenomas. Ann Endocrinol (Paris). 73:79–80. 2012. View Article : Google Scholar

3 

Heaney AP: Clinical review: Pituitary carcinoma: Difficult diagnosis and treatment. J Clin Endocrinol Metab. 96:3649–3660. 2011. View Article : Google Scholar

4 

Scheithauer BW, Kovacs KT, Laws ER Jr and Randall RV: Pathology of invasive pituitary tumors with special reference to functional classification. J Neurosurg. 65:733–744. 1986. View Article : Google Scholar

5 

Levy MJ, Matharu MS, Meeran K, Powell M and Goadsby PJ: The clinical characteristics of headache in patients with pituitary tumours. Brain. 128:1921–1930. 2005. View Article : Google Scholar

6 

Milos P, Havelius U and Hindfelt B: Clusterlike headache in a patient with a pituitary adenoma. With a review of the literature. Headache. 36:184–188. 1996. View Article : Google Scholar

7 

Kirk LF Jr, Hash RB, Katner HP and Jones T: Cushing's disease: Clinical manifestations and diagnostic evaluation. Am Fam Physician. 62(1119–1127): 1133–1134. 2000.

8 

Kumar V, Abbas A, Fausto N and Aster J: Robbins and Cotran pathologic basis of disease. 9th. Elsevier Health Sciences. ISBN 9780323296397 (eBook).

9 

Lee NM and Saha S: Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 40:309–334, vii. 2011. View Article : Google Scholar

10 

Sharma JB, Roy KK, Mohanraj P, Kumar S, Karmakar D and Barua J: Pregnancy outcome in pituitary tumors. Arch Gynecol Obstet. 280:401–404. 2009. View Article : Google Scholar

11 

Molitch ME: Pituitary tumors and pregnancy. Growth Horm IGF Res. 13:Suppl A. S38–S44. 2003. View Article : Google Scholar

12 

Kumar P and Magon N: Hormones in pregnancy. Niger Med J. 53:179–183. 2012. View Article : Google Scholar

13 

Karaca Z, Tanriverdi F, Unluhizarci K and Kelestimur F: Pregnancy and pituitary disorders. Eur J Endocrinol. 162:453–475. 2010. View Article : Google Scholar

14 

Molitch ME: Pituitary disorders during pregnancy. Endocrinol Metab Clin North Am. 35:99–116, vi. 2006. View Article : Google Scholar

15 

Mirshokraei P, Hassanpour H, Rahnama A and Foster WG: Gene expression of BDNF and its receptors, TrkB and p75 in the uterus and oviduct of pregnant and non-pregnant ewes. Res Vet Sci. 95:164–168. 2013. View Article : Google Scholar

16 

Okamura K, Harada T, Wang S, Ijichi K, Furuyama K, Koga T, Okamoto T, Takayama K, Yano T and Nakanishi Y: Expression of TrkB and BDNF is associated with poor prognosis in non-small cell lung cancer. Lung Cancer. 78:100–106. 2012. View Article : Google Scholar

17 

U.S. National Institutes of Health: Laboratory animal welfare: Public health service policy on humane care and use of laboratory animals by awardee institutions; notice. Fed Regist. 50:19584–19585. 1985.

18 

Ma H, Guo J, Xia J, Niu C, Shen X, Sun H and Zheng Y: Preparation and application of rabbit anti-mouse Setd8 polyclonal antibody. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 33:246–251. 2017.(In Chinese).

19 

Tomura M, Sakaue-Sawano A, Mori Y, Takase-Utsugi M, Hata A, Ohtawa K, Kanagawa O and Miyawaki A: Contrasting quiescent G0 phase with mitotic cell cycling in the mouse immune system. PLoS One. 8:e738012013. View Article : Google Scholar

20 

Prager D and Braunstein GD: Pituitary disorders during pregnancy. Endocrinol Metab Clin North Am. 24:1–14. 1995.

21 

Nader S: Pituitary disorders and pregnancy. Semin Perinatol. 14:24–33. 1990.

22 

Fung J, Gelaye B, Zhong QY, Rondon MB, Sanchez SE, Barrios YV, Hevner K, Qiu C and Williams MA: Association of decreased serum brain-derived neurotrophic factor (BDNF) concentrations in early pregnancy with antepartum depression. BMC Psychiatry. 15:432015. View Article : Google Scholar

23 

Evan GI and Vousden KH: Proliferation, cell cycle and apoptosis in cancer. Nature. 411:342–348. 2001. View Article : Google Scholar

24 

Beck B and Blanpain C: Unravelling cancer stem cell potential. Nat Rev Cancer. 13:727–738. 2013. View Article : Google Scholar

25 

Nguyen LV, Vanner R, Dirks P and Eaves CJ: Cancer stem cells: An evolving concept. Nat Rev Cancer. 12:133–143. 2012.

26 

Dean M: Cancer stem cells: Implications for cancer causation and therapy resistance. Discov Med. 5:278–282. 2005.

27 

Yang Y, Xu H, Huang W, Ding M, Xiao J, Yang D, Li H, Liu XY and Chu L: Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus. J Cell Mol Med. 19:915–923. 2015. View Article : Google Scholar

28 

Martín V, Sanchez-Sanchez AM, Herrera F, Gomez-Manzano C, Fueyo J, Alvarez-Vega MA, Antolín I and Rodriguez C: Melatonin-induced methylation of the ABCG2/BCRP promoter as a novel mechanism to overcome multidrug resistance in brain tumour stem cells. Br J Cancer. 108:2005–2012. 2013. View Article : Google Scholar

29 

Li N, Yang Y, Ding M, Huang W, Li H, Ye J, Xiao J, Zha X and Xu H: GFP stable transfection facilitated the characterization of lung cancer stem cells. Mol Biotechnol. 56:1079–1088. 2014. View Article : Google Scholar

30 

Chen K, Huang YH and Chen JL: Understanding and targeting cancer stem cells: Therapeutic implications and challenges. Acta Pharmacol Sin. 34:732–740. 2013. View Article : Google Scholar

31 

Andoniadou CL, Matsushima D, Gharavy Mousavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P, Jacques TS, Le Tissier P, et al: Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential. Cell Stem Cell. 13:433–445. 2013. View Article : Google Scholar

32 

Tunici P and Yu JS: Pituitary adenoma stem cells. Methods Mol Biol. 568:195–201. 2009. View Article : Google Scholar

33 

Chen SQ, Cai Q, Shen YY, Cai XY and Lei HY: Combined use of NGF/BDNF/bFGF promotes proliferation and differentiation of neural stem cells in vitro. Int J Dev Neurosci. 38:74–78. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yin C and Qi X: Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle. Oncol Lett 14: 4873-4877, 2017.
APA
Yin, C., & Qi, X. (2017). Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle. Oncology Letters, 14, 4873-4877. https://doi.org/10.3892/ol.2017.6756
MLA
Yin, C., Qi, X."Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle". Oncology Letters 14.4 (2017): 4873-4877.
Chicago
Yin, C., Qi, X."Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle". Oncology Letters 14, no. 4 (2017): 4873-4877. https://doi.org/10.3892/ol.2017.6756
Copy and paste a formatted citation
x
Spandidos Publications style
Yin C and Qi X: Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle. Oncol Lett 14: 4873-4877, 2017.
APA
Yin, C., & Qi, X. (2017). Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle. Oncology Letters, 14, 4873-4877. https://doi.org/10.3892/ol.2017.6756
MLA
Yin, C., Qi, X."Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle". Oncology Letters 14.4 (2017): 4873-4877.
Chicago
Yin, C., Qi, X."Pregnancy promotes pituitary tumors by increasing the rate of the cell cycle". Oncology Letters 14, no. 4 (2017): 4873-4877. https://doi.org/10.3892/ol.2017.6756
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