Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma

Proungvitaya,Siriporn; Sombattheera,Sutthikan; Boonsiri,Patcharee; Limpaiboon,Temduang; Wongkham,Sopit; Wongkham,Chaisiri; Titapun,Attapol; Proungvitaya,Tanakorn

doi:10.3892/ol.2017.6763

October-2017 Volume 14 Issue 4

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October-2017 Volume 14 Issue 4

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Article

Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma

Authors:
- Siriporn Proungvitaya
- Sutthikan Sombattheera
- Patcharee Boonsiri
- Temduang Limpaiboon
- Sopit Wongkham
- Chaisiri Wongkham
- Attapol Titapun
- Tanakorn Proungvitaya
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Affiliations: Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand, Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand, Liver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen 40002, Thailand
Pages: 4943-4948
|
Published online on: August 17, 2017

https://doi.org/10.3892/ol.2017.6763
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Abstract

Cholangiocarcinoma (CCA) is a cancer of biliary epithelial cell origin, which is prevalent in northeastern Thailand. The majority of patients with CCA are diagnosed at the advanced‑stage of the disease. Although the early detection and diagnosis of CCA is critical to improve the prognosis of patients, there are presently no specific tumor markers for CCA. A previous study demonstrated that the total serum bile acid (TSBA) levels of patients with CCA are significantly increased, compared with those of healthy controls. In addition, although statistically insignificant, the TSBA levels in the sera of patients with CCA tended to be increased, as compared with the sera of patients with benign biliary disease (BBD). In the present study, the high performance liquid chromatographic (HPLC) patterns of bile acid composition were compared in the sera of patients with CCA, patients with BBD and normal controls. The results revealed that serum bile acid patterns in patients with CCA varied, compared with those in patients with BBD and normal controls. As hypothesized, glycocholic acid (GCA) levels in the sera of patients with CCA and BBD were high, compared with those in healthy controls. In addition, GCA levels in the sera of patients with CCA tended to be higher, as compared with patients with BBD; however, this result was not statistically significant. Therefore, determination of the bile acid patterns and GCA levels in sera using HPLC is feasible, and may aid the diagnosis of CCA.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma

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