Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma

  • Authors:
    • Siriporn Proungvitaya
    • Sutthikan Sombattheera
    • Patcharee Boonsiri
    • Temduang Limpaiboon
    • Sopit Wongkham
    • Chaisiri Wongkham
    • Attapol Titapun
    • Tanakorn Proungvitaya
  • View Affiliations

  • Published online on: August 17, 2017     https://doi.org/10.3892/ol.2017.6763
  • Pages: 4943-4948
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Abstract

Cholangiocarcinoma (CCA) is a cancer of biliary epithelial cell origin, which is prevalent in northeastern Thailand. The majority of patients with CCA are diagnosed at the advanced‑stage of the disease. Although the early detection and diagnosis of CCA is critical to improve the prognosis of patients, there are presently no specific tumor markers for CCA. A previous study demonstrated that the total serum bile acid (TSBA) levels of patients with CCA are significantly increased, compared with those of healthy controls. In addition, although statistically insignificant, the TSBA levels in the sera of patients with CCA tended to be increased, as compared with the sera of patients with benign biliary disease (BBD). In the present study, the high performance liquid chromatographic (HPLC) patterns of bile acid composition were compared in the sera of patients with CCA, patients with BBD and normal controls. The results revealed that serum bile acid patterns in patients with CCA varied, compared with those in patients with BBD and normal controls. As hypothesized, glycocholic acid (GCA) levels in the sera of patients with CCA and BBD were high, compared with those in healthy controls. In addition, GCA levels in the sera of patients with CCA tended to be higher, as compared with patients with BBD; however, this result was not statistically significant. Therefore, determination of the bile acid patterns and GCA levels in sera using HPLC is feasible, and may aid the diagnosis of CCA.
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October-2017
Volume 14 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Proungvitaya S, Sombattheera S, Boonsiri P, Limpaiboon T, Wongkham S, Wongkham C, Titapun A and Proungvitaya T: Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma. Oncol Lett 14: 4943-4948, 2017
APA
Proungvitaya, S., Sombattheera, S., Boonsiri, P., Limpaiboon, T., Wongkham, S., Wongkham, C. ... Proungvitaya, T. (2017). Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma. Oncology Letters, 14, 4943-4948. https://doi.org/10.3892/ol.2017.6763
MLA
Proungvitaya, S., Sombattheera, S., Boonsiri, P., Limpaiboon, T., Wongkham, S., Wongkham, C., Titapun, A., Proungvitaya, T."Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma". Oncology Letters 14.4 (2017): 4943-4948.
Chicago
Proungvitaya, S., Sombattheera, S., Boonsiri, P., Limpaiboon, T., Wongkham, S., Wongkham, C., Titapun, A., Proungvitaya, T."Diagnostic value of serum bile acid composition patterns and serum glycocholic acid levels in cholangiocarcinoma". Oncology Letters 14, no. 4 (2017): 4943-4948. https://doi.org/10.3892/ol.2017.6763