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Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study

  • Authors:
    • Jianhong Peng
    • Junzhong Lin
    • Zhifan Zeng
    • Xiaojun Wu
    • Gong Chen
    • Liren Li
    • Zhenhai Lu
    • Peirong Ding
    • Desen Wan
    • Zhizhong Pan
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiation Oncology, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4543-4550
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    Published online on: August 17, 2017
       https://doi.org/10.3892/ol.2017.6764
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Abstract

Our previous study reported the favorable short‑term outcome and good tolerance of integrating oxaliplatin into capecitabine‑based (XELOX regimen) preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). The present study reported the long‑term oncological outcome of this phase II study. A total of 47 patients with rectal adenocarcinoma (stage II or III) were enrolled and received radiotherapy (46 Gy in 23 fractions) in combination with capecitabine (1,000 mg/m2, twice daily, on days 1‑14 and 22‑35) and oxaliplatin (130 mg/m2 on days 1 and 22). Overall survival (OS) rate, disease‑free survival (DFS) rate and cumulative incidence of recurrences and long‑term complications were calculated or observed. As a result, 41 patients underwent surgery after preoperative CRT, and the cumulative OS rates at 1, 3 and 5 years for these patients were 100.0, 84.5 and 81.8%, respectively. For the 38 patients who received R0 resection, the cumulative OS rates at 1, 3 and 5 years were 100.0, 89.0 and 86.2%, respectively, while the cumulative DFS rates at 1, 3 and 5 years were 94.6, 75.3 and 69.7%, respectively. After follow‑up at 84 months, the cumulative incidence rates of local and distant recurrences at 5 years were 6.6 and 28.2%, respectively. Oxaliplatin‑associated long‑term complications were seldom observed. Overall, the addition of oxaliplatin to capecitabine‑based preoperative radiotherapy achieved favorable OS and DFS without increased long‑term complications in patients with LARC. Therefore, this preoperative CRT strategy is a feasible option for such patients.
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Copy and paste a formatted citation
Spandidos Publications style
Peng J, Lin J, Zeng Z, Wu X, Chen G, Li L, Lu Z, Ding P, Wan D, Pan Z, Pan Z, et al: Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study. Oncol Lett 14: 4543-4550, 2017.
APA
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L. ... Pan, Z. (2017). Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study. Oncology Letters, 14, 4543-4550. https://doi.org/10.3892/ol.2017.6764
MLA
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L., Lu, Z., Ding, P., Wan, D., Pan, Z."Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study". Oncology Letters 14.4 (2017): 4543-4550.
Chicago
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L., Lu, Z., Ding, P., Wan, D., Pan, Z."Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study". Oncology Letters 14, no. 4 (2017): 4543-4550. https://doi.org/10.3892/ol.2017.6764
Copy and paste a formatted citation
x
Spandidos Publications style
Peng J, Lin J, Zeng Z, Wu X, Chen G, Li L, Lu Z, Ding P, Wan D, Pan Z, Pan Z, et al: Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study. Oncol Lett 14: 4543-4550, 2017.
APA
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L. ... Pan, Z. (2017). Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study. Oncology Letters, 14, 4543-4550. https://doi.org/10.3892/ol.2017.6764
MLA
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L., Lu, Z., Ding, P., Wan, D., Pan, Z."Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study". Oncology Letters 14.4 (2017): 4543-4550.
Chicago
Peng, J., Lin, J., Zeng, Z., Wu, X., Chen, G., Li, L., Lu, Z., Ding, P., Wan, D., Pan, Z."Addition of oxaliplatin to capecitabine‑based preoperative chemoradiotherapy for locally advanced rectal cancer: Long‑term outcome of a phase II study". Oncology Letters 14, no. 4 (2017): 4543-4550. https://doi.org/10.3892/ol.2017.6764
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