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Article Open Access

Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma

Retraction in: /10.3892/ol.2018.7736
  • Authors:
    • Sheng‑Xing Zhu
    • Xian‑Zhou Tong
    • Shuijun Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China, Department of The Second General Surgery, People's Hospital of Zhengzhou, Zhengzhou, Henan 450000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4505-4510
    |
    Published online on: August 21, 2017
       https://doi.org/10.3892/ol.2017.6777
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Abstract

MicroRNAs (miRs) are involved in many aspects of cell biology, including cell proliferation and apoptosis, two critical aspects of tumor biology. We investigated the effect of miR‑711 on Bcl‑2 expression in human MGC803 gastric cancer cells and the mechanism of cell proliferation, apoptosis, and invasion. Expression of miR‑711 and Bcl‑2 was significantly increased in gastric adenocarcinoma compared to adjacent normal tissue. Inhibition of miR‑711 in MGC803 gastric cancer cells decreased the expression of Bcl‑2, decreased cell proliferation, decreased the invasion ability, and increased apoptosis. The expression of Bcl‑2 protein correlated with clinical staging, lymph node metastasis, and tumor differentiation in patients with gastric cancer. The expression of miR‑711 positively correlated with the expression of Bcl‑2, suggesting that miR‑711 and Bcl‑2 are co‑regulated and involved in the development of gastric cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu SX, Tong XZ and Zhang S: Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736. Oncol Lett 14: 4505-4510, 2017.
APA
Zhu, S., Tong, X., & Zhang, S. (2017). Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736. Oncology Letters, 14, 4505-4510. https://doi.org/10.3892/ol.2017.6777
MLA
Zhu, S., Tong, X., Zhang, S."Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736". Oncology Letters 14.4 (2017): 4505-4510.
Chicago
Zhu, S., Tong, X., Zhang, S."Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736". Oncology Letters 14, no. 4 (2017): 4505-4510. https://doi.org/10.3892/ol.2017.6777
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu SX, Tong XZ and Zhang S: Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736. Oncol Lett 14: 4505-4510, 2017.
APA
Zhu, S., Tong, X., & Zhang, S. (2017). Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736. Oncology Letters, 14, 4505-4510. https://doi.org/10.3892/ol.2017.6777
MLA
Zhu, S., Tong, X., Zhang, S."Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736". Oncology Letters 14.4 (2017): 4505-4510.
Chicago
Zhu, S., Tong, X., Zhang, S."Expression of miR‑711 and mechanism of proliferation and apoptosis in human gastric carcinoma Retraction in /10.3892/ol.2018.7736". Oncology Letters 14, no. 4 (2017): 4505-4510. https://doi.org/10.3892/ol.2017.6777
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