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Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma

  • Authors:
    • Jing Peng
    • Hai‑Cheng Wang
    • Yang Liu
    • Jiu‑Hui Jiang
    • Wan‑Qi Lv
    • Yue Yang
    • Cui‑Ying Li
    • Xiao‑Yan Qiu
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China, Department of Oral Pathology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072, P.R. China, Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China, Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China, Department of Dentistry, Capital Medical University Xuanwu Hospital, Beijing 100053, P.R. China
    Copyright: © Peng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4491-4498
    |
    Published online on: August 21, 2017
       https://doi.org/10.3892/ol.2017.6782
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Abstract

Cancer cell‑derived immunoglobulin G (cancer‑IgG) has been implicated in the pathogenesis and progression of various types of cancer. However, its role in salivary adenoid cystic carcinoma (SACC) remains unclear. The present study aimed to investigate the effects of cancer‑IgG on metastasis and prognosis in 96 patients with SACC. Immunohistochemical staining showed that cancer‑IgG expression was present in all 96 individual SACC tissues. Additionally, high cancer‑IgG expression was significantly correlated with metastasis, nerve invasion and recurrence in SACC (P<0.05). Moreover, cancer‑IgG expression was significantly correlated with the survival duration of patients with SACC (P<0.05). Proliferation, cell motility and invasion all decreased significantly following knockdown of cancer‑IgG in SACC cells (P<0.05) through population‑doubling time, wound healing and transwell invasion assays. Additionally, cancer‑IgG‑knockdown in SACC cells induced the increased expression of E‑cadherin and matrix metalloproteinase 9, and promoted the epithelial‑mesenchymal transition, but decreased the expression of F‑actin filaments. Taken together, these results showed that the high expression of cancer‑IgG was strongly associated with metastasis, recurrence and invasion in SACC, suggesting that cancer‑IgG expression could serve as a useful biomarker to predict the prognosis of the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Peng J, Wang HC, Liu Y, Jiang JH, Lv WQ, Yang Y, Li CY and Qiu XY: Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncol Lett 14: 4491-4498, 2017.
APA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y. ... Qiu, X. (2017). Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncology Letters, 14, 4491-4498. https://doi.org/10.3892/ol.2017.6782
MLA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14.4 (2017): 4491-4498.
Chicago
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14, no. 4 (2017): 4491-4498. https://doi.org/10.3892/ol.2017.6782
Copy and paste a formatted citation
x
Spandidos Publications style
Peng J, Wang HC, Liu Y, Jiang JH, Lv WQ, Yang Y, Li CY and Qiu XY: Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncol Lett 14: 4491-4498, 2017.
APA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y. ... Qiu, X. (2017). Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma. Oncology Letters, 14, 4491-4498. https://doi.org/10.3892/ol.2017.6782
MLA
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14.4 (2017): 4491-4498.
Chicago
Peng, J., Wang, H., Liu, Y., Jiang, J., Lv, W., Yang, Y., Li, C., Qiu, X."Involvement of non‑B cell‑derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma". Oncology Letters 14, no. 4 (2017): 4491-4498. https://doi.org/10.3892/ol.2017.6782
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