Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2017 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer

  • Authors:
    • Changcheng Yang
    • Manlin Cao
    • Yiwen Liu
    • Yiqing He
    • Cuixia Yang
    • Yan Du
    • Wenjuan Wang
    • Guoliang Zhang
    • Man Wu
    • Muqing Zhou
    • Feng Gao
  • View Affiliations / Copyright

    Affiliations: Department of Molecular Biology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Department of Rehabilitation Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China, Department of Molecular Biology and Clinical Laboratory, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4758-4766
    |
    Published online on: August 23, 2017
       https://doi.org/10.3892/ol.2017.6791
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Carcinoembryonic antigen‑related cell adhesion molecule 1 (CEACAM1), a cell‑cell adhesion molecule, has been revealed to perform an important role in tumor progression. Although there are a number of studies on CEACAM1 in patients with breast cancer, there is limited information on the roles of CEACAM1 in breast cancer metastasis. The present study aimed to identify whether CEACAM1 is involved in breast cancer development and to investigate the underlying mechanisms. First, the expression of CEACAM1 was observed in patients with breast cancer, and the association between CEACAM1 expression levels and migration and invasion of breast cancer cells was analyzed. As there are 12 isoforms of CEACAM1, of which CEACAM1‑4S dominates in the human breast epithelium, subsequent study focused on CEACAM1‑4S as a representative of all the isoforms. Results of the present study demonstrated that CEACAM1‑4S suppresses breast cancer cell invasion and migration in a manner that is dependent on the balance between matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2 and E‑/N‑cadherin expression. In addition, CEACAM1‑4S was likely to cause reversal of epithelial‑mesenchymal transition of breast cancer cells through repressing Smad2 and signal transducer and phosphorylation of activator of transcription 3. In conclusion, the present study demonstrated that CEACAM1‑4S performs an inhibitory role in breast cancer metastasis, and restoring CEACAM1‑4S expression may provide a novel strategy for therapy of patients with metastatic breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Weigelt B, Peterse JL and van 't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Gray-Owen SD and Blumberg RS: CEACAM1: Contact-dependent control of immunity. Nat Rev Immunol. 6:433–446. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Prall F, Nollau P, Neumaier M, Haubeck HD, Drzeniek Z, Helmchen U, Löning T and Wagener C: CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium and myeloid cells in a wide range of normal human tissues. J Histochem Cytochem. 44:35–41. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Neumaier M, Paululat S, Chan A, Matthaes P and Wagener C: Biliary glycoprotein, a potential human cell adhesion molecule, is down-regulated in colorectal carcinomas. Proc Natl Acad Sci USA. 90:10744–10748. 1993. View Article : Google Scholar : PubMed/NCBI

6 

Tanaka K, Hinoda Y, Takahashi H, Sakamoto H, Nakajima Y and Imai K: Decreased expression of biliary glycoprotein in hepatocellular carcinomas. Int J Cancer. 74:15–19. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Kammerer R, Riesenberg R, Weiler C, Lohrmann J, Schleypen J and Zimmermann W: The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinoma. J Pathol. 204:258–267. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Busch C, Hanssen TA, Wagener C and OBrink B: Down-regulation of CEACAM1 in human prostate cancer: Correlation with loss of cell polarity, increased proliferation rate and Gleason grade 3 to 4 transition. Hum Pathol. 33:290–298. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Nittka S, Gunther J, Ebisch C, Erbersdobler A and Neumaier M: The human tumor suppressor CEACAM1 modulates apoptosis and is implicated in early colorectal tumorigenesis. Oncogene. 23:9306–9313. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Estrera VT, Chen DT, Luo W, Hixson DC and Lin SH: Signal transduction by the CEACAM1 tumor suppressor. Phosphorylation of serine 503 is required for growth-inhibitory activity. J Biol Chem. 276:15547–15553. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Wang JL, Sun SZ, Qu X, Liu WJ, Wang YY, Lv CX, Sun JZ and Ma R: Clinicopathological significance of CEACAM1 gene expression in breast cancer. Chin J Physiol. 54:332–338. 2011.PubMed/NCBI

12 

Yang C, He P, Liu Y, He Y, Yang C, Du Y, Zhou M, Wang W, Zhang G, Wu M and Gao F: Down-regulation of CEACAM1 in breast cancer. Acta Biochim Biophys Sin (Shanghai). 47:788–794. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Riethdorf L, Lisboa BW, Henkel U, Naumann M, Wagener C and Loning T: Differential expression of CD66a (BGP), a cell adhesion molecule of the carcinoembryonic antigen family, in benign, premalignant and malignant lesions of the human mammary gland. J Histochem Cytochem. 45:957–963. 1997. View Article : Google Scholar : PubMed/NCBI

14 

Huang J, Hardy JD, Sun Y and Shively JE: Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J Cell Sci. 112:4193–4205. 1999.PubMed/NCBI

15 

Kirshner J, Chen CJ, Liu P, Huang J and Shively JE: CEACAM1-4S, a cell-cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture. Proc Natl Acad Sci USA. 100:521–526. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Tavassoli FA and Devilee P: World Health Organization classification of tumors Pathology and genetics of tumors of the breast and female genital organs. Lyon: IARC Press; 2003

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Oliveira-Ferrer L, Tilki D, Ziegeler G, Hauschild J, Loges S, Irmak S, Kilic E, Huland H, Friedrich M and Ergün S: Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Cancer Res. 64:8932–8. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Beauchemin N and Arabzadeh A: Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis. Cancer Metastasis Rev. 32:643–671. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Kirshner J, Hardy J, Wilczynski S and Shively JE: Cell-cell adhesion molecule CEACAM1 is expressed in normal breast and milk and associates with beta1 integrin a 3D model of morphogenesis. J Mol Histol. 35:287–299. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Chakrabarti R, Hwang J, Blanco Andres M, Wei Y, Lukačišin M, Romano RA, Smalley K, Liu S, Yang Q, Ibrahim T, et al: Elf5 inhibits the epithelial -mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol. 14:1212–1222. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Said AH, Raufman JP and Xie G: The role of matrix metalloproteinases in colorectal cancer. Cancers. 6:366–375. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Derycke LD and Bracke ME: N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signalling. Int J Dev Biol. 48:463–476. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Liu J, Di G, Wu CT, Hu X and Duan H: CEACAM1 inhibits cell-matrix adhesion and promotes cell migration through regulating the expression of N-cadherin. Biochem Biophys Res Commun. 430:598–603. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED and Thompson EW: Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol. 213:374–383. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Luo WP, Wood CG, Earley K, Hung MC and Lin SH: Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): The adhesion and growth suppression are mediated by different domains. Oncogene. 14:1697–1704. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Obrink B: Is CEACAM1 a lymphangiogenic switch? Blood. 110:4137–4138. 2007. View Article : Google Scholar

29 

Ebrahimnejad A, Streichert T, Nollau P, Horst AK, Wagener C, Bamberger AM and Brümmer J: CEACAM1 enhances invasion and migration of melanocytic and melanoma cells. Am J Pathol. 165:1781–1787. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Liu W, Wei W, Winer D, Bamberger AM, Bamberger C, Wagener C, Ezzat S and Asa SL: CEACAM1 impedes thyroid cancer growth but promotes invasiveness: A putative mechanism for early metastases. Oncogene. 26:2747–2758. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Luo W, Tapolsky M, Earley K, Wood CG, Wilson DR, Logothetis CJ and Lin SH: Tumor-suppressive activity of CD66a in prostate cancer. Cancer Gene Ther. 6:313–321. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Volpert O, Luo W, Liu TJ, Estrera VT, Logothetis C and Lin SH: Inhibition of prostate tumor angiogenesis by the tumor suppressor CEACAM1. J Biol Chem. 277:35696–35702. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Ieda J, Yokoyama S, Tamura K, Takifuji K, Hotta T, Matsuda K, Oku Y, Nasu T, Kiriyama S, Yamamoto N, et al: Re-expression of CEACAM1 long cytoplasmic domain isoform is associated with invasion and migration of colorectal cancer. Int J Cancer. 129:1351–1361. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Kiriyama S, Yokoyama S, Ueno M, Hayami S, Ieda J, Yamamoto N, Yamaguchi S, Mitani Y, Nakamura Y, Tani M, et al: CEACAM1 long cytoplasmic domain isoform is associated with invasion and recurrence of hepatocellular carcinoma. Ann Surg Oncol. 21 Suppl 4:S505–S514. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Stamenkovic I: Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol. 10:415–433. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Cavallaro U and Christofori G: Cell adhesion and signaling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer. 4:118–132. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y and Johnson KR: Cadherin switching. J Cell Sci. 121:727–735. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Theveneau E and Mayor R: Cadherins in collective cell migration of mesenchymal cells. Curr Opin Cell Biol. 24:677–684. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Nakada M, Nakada S, Demuth T, Tran NL, Hoelzinger DB and Berens ME: Molecular targets of glioma invasion. Cell Mol Life Sci. 64:458–478. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang C, Cao M, Liu Y, He Y, Yang C, Du Y, Wang W, Zhang G, Wu M, Zhou M, Zhou M, et al: Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer. Oncol Lett 14: 4758-4766, 2017.
APA
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y. ... Gao, F. (2017). Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer. Oncology Letters, 14, 4758-4766. https://doi.org/10.3892/ol.2017.6791
MLA
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y., Wang, W., Zhang, G., Wu, M., Zhou, M., Gao, F."Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer". Oncology Letters 14.4 (2017): 4758-4766.
Chicago
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y., Wang, W., Zhang, G., Wu, M., Zhou, M., Gao, F."Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer". Oncology Letters 14, no. 4 (2017): 4758-4766. https://doi.org/10.3892/ol.2017.6791
Copy and paste a formatted citation
x
Spandidos Publications style
Yang C, Cao M, Liu Y, He Y, Yang C, Du Y, Wang W, Zhang G, Wu M, Zhou M, Zhou M, et al: Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer. Oncol Lett 14: 4758-4766, 2017.
APA
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y. ... Gao, F. (2017). Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer. Oncology Letters, 14, 4758-4766. https://doi.org/10.3892/ol.2017.6791
MLA
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y., Wang, W., Zhang, G., Wu, M., Zhou, M., Gao, F."Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer". Oncology Letters 14.4 (2017): 4758-4766.
Chicago
Yang, C., Cao, M., Liu, Y., He, Y., Yang, C., Du, Y., Wang, W., Zhang, G., Wu, M., Zhou, M., Gao, F."Inhibition of cell invasion and migration by CEACAM1‑4S in breast cancer". Oncology Letters 14, no. 4 (2017): 4758-4766. https://doi.org/10.3892/ol.2017.6791
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team