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HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid

  • Authors:
    • Jiwei Qiao
    • Chunyu Li
    • Yuying Zhang
    • Shuangyan Wang
    • Shan Gao
  • View Affiliations / Copyright

    Affiliations: Longnan Hospital of Daqing City, Daqing, Heilongjiang 163453, P.R. China, Daqing Hospital of Traditional Chinese Medicine, Daqing, Heilongjiang 163312, P.R. China
    Copyright: © Qiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6505-6510
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6971
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Abstract

We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1. We further analyzed the correlation of the expression of HBME-1 in the papillary carcinoma group and the follicular carcinoma group with ultrasonic manifestation of thyroid. In both the papillary carcinoma group and the follicular carcinoma group, the levels of HBME-1 in affected tissues and the IHS score of HBME-1 expression were higher than those in the control group (p<0.05). In the papillary carcinoma group, the mean IHS score of HBME-1 expression in affected tissues was higher than in the follicular carcinoma group (p<0.05). There were no statistically significant differences in comparison to HBME-1 expression in affected tissues between the papillary carcinoma group and the follicular carcinoma group (p>0.05). Between the papillary carcinoma group and the follicular carcinoma group, the differences in the comparison of the nodule diameter, echo, shape, boundary, calcification and blood flow signal were statistically significant (p<0.05), but incidence rate of enlargement of cervical lymph nodules between the groups were not statistically significant (p>0.05). Among patients in the papillary carcinoma group, the comparison of the nodule diameter, echo, shape, boundary, calcification and blood flow signal between the HBME-1‑positive patients and the HBME‑1-negative patients showed no statistical significance (p>0.05), but in the nodules of HBME-1-positive patients, the proportion of blood flow signal was higher than that in the nodules of HBME-1-negative patients. Among patients in the follicular carcinoma group, there was no statistically significant differences in the comparison of ultrasonic manifestation of thyroid (p>0.05). Therefore, there are difference in HBME-1 expression and ultrasonic manifestations of thyroid in patients with papillary carcinoma and follicular differentiated thyroid carcinoma.
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1 

Asa SL, Giordano TJ and LiVolsi VA: Implications of the TCGA genomic characterization of papillary thyroid carcinoma for thyroid pathology: Does follicular variant papillary thyroid carcinoma exist? Thyroid. 25:1–2. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Mebed AH: Aggressive surgical therapy for locally invasive differentiated thyroid carcinoma: An experience of nineteen (19) cases. J Egypt Natl Canc Inst. 19:282–291. 2007.PubMed/NCBI

3 

Paschke R, Lincke T, Müller SP, Kreissl MC, Dralle H and Fassnacht M: The Treatment of Well-Differentiated Thyroid Carcinoma. Dtsch Arztebl Int. 112:452–458. 2015.PubMed/NCBI

4 

Xu D, Wang L, Long B, Ye X, Ge M, Wang K, Guo L and Li L: Radiofrequency ablation for postsurgical thyroid removal of differentiated thyroid carcinoma. Am J Transl Res. 8:1876–1885. 2016.PubMed/NCBI

5 

Cantisani V, Maceroni P, DAndrea V, Patrizi G, Di Segni M, De Vito C, Grazhdani H, Isidori AM, Giannetta E, Redler A, et al: Strain ratio ultrasound elastography increases the accuracy of colour-Doppler ultrasound in the evaluation of Thy-3 nodules. A bi-centre university experience. Eur Radiol. 26:1441–1449. 2016. View Article : Google Scholar : PubMed/NCBI

6 

de Matos PS, Ferreira AP, de Oliveira Facuri F, Assumpção LV, Metze K and Ward LS: Usefulness of HBME-1, cytokeratin 19 and galectin-3 immunostaining in the diagnosis of thyroid malignancy. Histopathology. 47:391–401. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Sadamori H, Yagi T, Iwagaki H, Matsuda H, Shinoura S, Umeda Y, Ohara N, Yanai H, Ogino T and Tanaka N: Immunohistochemical staining of liver grafts with a monoclonal antibody against HCV-Envelope 2 for recurrent hepatitis C after living donor liver transplantation. J Gastroenterol Hepatol. 24:574–580. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Verslype C, Nevens F, Sinelli N, Clarysse C, Pirenne J, Depla E, Maertens G, van Pelt J, Desmet V, Fevery J, et al: Hepatic immunohistochemical staining with a monoclonal antibody against HCV-E2 to evaluate antiviral therapy and reinfection of liver grafts in hepatitis C viral infection. J Hepatol. 38:208–214. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Casey MB, Lohse CM and Lloyd RV: Distinction between papillary thyroid hyperplasia and papillary thyroid carcinoma by immunohistochemical staining for cytokeratin 19, galectin-3, and HBME-1. Endocr Pathol. 14:55–60. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Lee YS, Yun JS, Jeong JJ, Nam KH, Chung WY and Park CS: Thyroid hemiagenesis associated with thyroid adenomatous hyperplasia and papillary thyroid carcinoma. Thyroid. 18:381–382. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Dong S, Song XS, Chen G and Liu J: Mixed primary squamous cell carcinoma, follicular carcinoma, and micropapillary carcinoma of the thyroid gland: A case report. Auris Nasus Larynx. 43:455–459. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Bychkov A, Sampatanukul P, Shuangshoti S and Keelawat S: TROP-2 immunohistochemistry: A highly accurate method in the differential diagnosis of papillary thyroid carcinoma. Pathology. 48:425–433. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Erdogan-Durmus S, Ozcan D, Yarikkaya E, Kurt A and Arslan A: CD56, HBME-1 and cytokeratin 19 expressions in papillary thyroid carcinoma and nodular thyroid lesions. J Res Med Sci. 21:49–54. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Chen YJ, Zhao RM, Zhao Q, Li BY, Ma QY, Li X and Chen X: Diagnostic significance of elevated expression of HBME-1 in papillary thyroid carcinoma. Tumour Biol. 37:8715–8720. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Zhu X, Sun T, Lu H, Zhou X, Lu Y, Cai X and Zhu X: Diagnostic significance of CK19, RET, galectin-3 and HBME-1 expression for papillary thyroid carcinoma. J Clin Pathol. 63:786–789. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Liu Z, Yu P, Xiong Y, Zeng W, Li X, Maiaiti Y, Wang S, Song H, Shi L, Liu C, et al: Significance of CK19, TPO, and HBME-1 expression for diagnosis of papillary thyroid carcinoma. Int J Clin Exp Med. 8:4369–4374. 2015.PubMed/NCBI

17 

El-Mahdy MM, Mabrouk SH, El-Din ZS, Ghazal FA and Mohamed HH: Diagnostic value of HBME-1 and CK19 expression in papillary thyroid carcinoma, well-differentiated tumors of uncertain malignant potential, and benign thyroid nodules. Egypt J Pathol. 31:68–74. 2011. View Article : Google Scholar

18 

Chao TT, Maa HC, Wang CY, Pei D, Liang YJ, Yang YF, Chou SJ and Chen YL: CIP2A is a poor prognostic factor and can be a diagnostic marker in papillary thyroid carcinoma. APMIS. 124:1031–1037. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yeşil C, Kandemir O, Haksever H and Dabakoğlu T: Is BECLIN-1 immunoreactivity more effective than HBME-1 in diagnosis of papillary thyroid cancer? Acta Chir Belg. 115:299–305. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qiao J, Li C, Zhang Y, Wang S and Gao S: HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid. Oncol Lett 14: 6505-6510, 2017.
APA
Qiao, J., Li, C., Zhang, Y., Wang, S., & Gao, S. (2017). HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid. Oncology Letters, 14, 6505-6510. https://doi.org/10.3892/ol.2017.6971
MLA
Qiao, J., Li, C., Zhang, Y., Wang, S., Gao, S."HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid". Oncology Letters 14.6 (2017): 6505-6510.
Chicago
Qiao, J., Li, C., Zhang, Y., Wang, S., Gao, S."HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid". Oncology Letters 14, no. 6 (2017): 6505-6510. https://doi.org/10.3892/ol.2017.6971
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao J, Li C, Zhang Y, Wang S and Gao S: HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid. Oncol Lett 14: 6505-6510, 2017.
APA
Qiao, J., Li, C., Zhang, Y., Wang, S., & Gao, S. (2017). HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid. Oncology Letters, 14, 6505-6510. https://doi.org/10.3892/ol.2017.6971
MLA
Qiao, J., Li, C., Zhang, Y., Wang, S., Gao, S."HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid". Oncology Letters 14.6 (2017): 6505-6510.
Chicago
Qiao, J., Li, C., Zhang, Y., Wang, S., Gao, S."HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid". Oncology Letters 14, no. 6 (2017): 6505-6510. https://doi.org/10.3892/ol.2017.6971
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