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Article Open Access

Expression of NF-κB and PTEN in osteosarcoma and its clinical significance

  • Authors:
    • Teng Gong
    • Xuetao Su
    • Qun Xia
    • Jinggui Wang
    • Shilian Kan
  • View Affiliations / Copyright

    Affiliations: Department of Spinal Surgery, Tianjin Hospital, Tianjin 300211, P.R. China, Department of Orthopaedic Surgery, The Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces, Tianjin 300162, P.R. China
    Copyright: © Gong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6744-6748
    |
    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6972
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Abstract

We investigated the role of nuclear factor-κB (NF-κB) and phosphatase and tensin homolog deleted in chromosome 10 (PTEN) in the pathogenesis of osteosarcoma and its relationship with prognosis. Immunohistochemical method was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues. RT-PCR was used to detect the expression of NF-κB and PTEN mRNA in osteosarcoma and adjacent tissues. Western blotting was used to detect the expression of NF-κB and PTEN in osteosarcoma and adjacent tissues and compare their differences. The expression of NF-κB and PTEN was detected in osteosarcoma and adjacent tissues. The positive rate of NF-κB was 75.3 and 32.9%, respectively; while the positive rate of PTEN was 67.1 and 90.4%, respectively. The positive expression of NF-κB and PTEN was statistically significant. There was a negative correlation between NF-κB and PTEN expression (r=-0.502, p<0.05). The positive and negative expression of NF-κB and PTEN was statistically significant for the five-year survival (p<0.05). At gene and protein level, osteosarcoma tissues had higher expression of NF-κB, and lower expression of PTEN, which was significantly different from the adjacent tissues. In osteosarcoma, NF-κB is highly expressed, but PTEN is expressed at low level, and the two are negatively correlated. This is of great significance for the early diagnosis of osteosarcoma and prognosis.
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1 

Gao KT and Lian D: Long non-coding RNA MALAT1 is an independent prognostic factor of osteosarcoma. Eur Rev Med Pharmacol Sci. 20:3561–3565. 2016.PubMed/NCBI

2 

Sun XZ, Liao Y and Zhou CM: NKD2 a novel marker to study the progression of osteosarcoma development. Eur Rev Med Pharmacol Sci. 20:2799–2804. 2016.PubMed/NCBI

3 

Yan M, Ni J, Song D, Ding M and Huang J: Activation of unfolded protein response protects osteosarcoma cells from cisplatin-induced apoptosis through NF-κB pathway. Int J Clin Exp Pathol. 8:10204–10215. 2015.PubMed/NCBI

4 

Xia M, Tong JH, Ji NN, Duan ML, Tan YH and Xu JG: Tramadol regulates proliferation, migration and invasion via PTEN/PI3K/AKT signaling in lung adenocarcinoma cells. Eur Rev Med Pharmacol Sci. 20:2573–2580. 2016.PubMed/NCBI

5 

Ersahin A, Acet M, Acet T and Yavuz Y: Disturbed endometrial NF-κB expression in women with recurrent implantation failure. Eur Rev Med Pharmacol Sci. 20:5037–5040. 2016.PubMed/NCBI

6 

Wang L, Yang L, Lu Y, Chen Y, Liu T, Peng Y, Zhou Y, Cao Y, Bi Z, Liu T, et al: Osthole induces cell cycle arrest and inhibits migration and invasion via PTEN/Akt pathways in osteosarcoma. Cell Physiol Biochem. 38:2173–2182. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Ma T, Guo CJ, Zhao X, Wu L, Sun SX and Jin QH: The effect of curcumin on NF-κB expression in rat with lumbar intervertebral disc degeneration. Eur Rev Med Pharmacol Sci. 19:1305–1314. 2015.PubMed/NCBI

8 

Shen L, Chen XD and Zhang YH: MicroRNA-128 promotes proliferation in osteosarcoma cells by downregulating PTEN. Tumour Biol. 35:2069–2074. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Pang PC, Shi XY, Huang WL and Sun K: miR-497 as a potential serum biomarker for the diagnosis and prognosis of osteosarcoma. Eur Rev Med Pharmacol Sci. 20:3765–3769. 2016.PubMed/NCBI

10 

Ju L, Zhou YM and Yang GS: Up-regulation of long non-coding RNA BCAR4 predicts a poor prognosis in patients with osteosarcoma, and promotes cell invasion and metastasis. Eur Rev Med Pharmacol Sci. 20:4445–4451. 2016.PubMed/NCBI

11 

Sun H, Zheng X, Wang Q, Yan J, Li D, Zhou Y, Lin Y, Zhang L and Wang X: Concurrent blockade of NF-κB and Akt pathways potentiates cisplatin's antitumor activity in vivo. Anticancer Drugs. 23:1039–1046. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Mongre RK, Sodhi SS, Ghosh M, Kim JH, Kim N, Sharma N and Jeong DK: A new paradigm to mitigate osteosarcoma by regulation of microRNAs and suppression of the NF-κB signaling cascade. Dev Reprod. 18:197–212. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Liu CJ, Yu KL, Liu GL and Tian DH: MiR 214 promotes osteosarcoma tumor growth and metastasis by decreasing the expression of PTEN. Mol Med Rep. 12:6261–6266. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kawano M, Tanaka K, Itonaga I, Ikeda S, Iwasaki T and Tsumura H: microRNA-93 promotes cell proliferation via targeting of PTEN in osteosarcoma cells. J Exp Clin Cancer Res. 34:762015. View Article : Google Scholar : PubMed/NCBI

15 

Shang ZM, Tang JD, Jiang QQ, Guo A, Zhang N, Gao ZX and Ji WS: Role of Δ133p53 in tumor necrosis factor-induced survival of p53 functions in MKN45 gastric cancer cell line. Eur Rev Med Pharmacol Sci. 19:2416–2422. 2015.PubMed/NCBI

16 

Tian Z, Guo B, Yu M, Wang C, Zhang H, Liang Q, Jiang K and Cao L: Upregulation of micro-ribonucleic acid-128 cooperating with downregulation of PTEN confers metastatic potential and unfavorable prognosis in patients with primary osteosarcoma. Onco Targets Ther. 7:1601–1608. 2014.PubMed/NCBI

17 

Hu Y, Xu S, Jin W, Yi Q and Wei W: Effect of the PTEN gene on adhesion, invasion and metastasis of osteosarcoma cells. Oncol Rep. 32:1741–1747. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Song D, Ni J, Xie H, Ding M and Wang J: DNA demethylation in the PTEN gene promoter induced by 5-azacytidine activates PTEN expression in the MG-63 human osteosarcoma cell line. Exp Ther Med. 7:1071–1076. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Loftus JP, Cavatorta D, Bushey JJ, Levine CB, Sevier CS and Wakshlag JJ: The 5-lipoxygenase inhibitor tepoxalin induces oxidative damage and altered PTEN status prior to apoptosis in canine osteosarcoma cell lines. Vet Comp Oncol. 14:e17–e30. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Lu Y, Li F, Xu T and Sun J: Tetrandrine prevents multidrug resistance in the osteosarcoma cell line, U-2OS, by preventing Pgp overexpression through the inhibition of NF-κB signaling. Int J Mol Med. 39:993–1000. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gong T, Su X, Xia Q, Wang J and Kan S: Expression of NF-κB and PTEN in osteosarcoma and its clinical significance. Oncol Lett 14: 6744-6748, 2017.
APA
Gong, T., Su, X., Xia, Q., Wang, J., & Kan, S. (2017). Expression of NF-κB and PTEN in osteosarcoma and its clinical significance. Oncology Letters, 14, 6744-6748. https://doi.org/10.3892/ol.2017.6972
MLA
Gong, T., Su, X., Xia, Q., Wang, J., Kan, S."Expression of NF-κB and PTEN in osteosarcoma and its clinical significance". Oncology Letters 14.6 (2017): 6744-6748.
Chicago
Gong, T., Su, X., Xia, Q., Wang, J., Kan, S."Expression of NF-κB and PTEN in osteosarcoma and its clinical significance". Oncology Letters 14, no. 6 (2017): 6744-6748. https://doi.org/10.3892/ol.2017.6972
Copy and paste a formatted citation
x
Spandidos Publications style
Gong T, Su X, Xia Q, Wang J and Kan S: Expression of NF-κB and PTEN in osteosarcoma and its clinical significance. Oncol Lett 14: 6744-6748, 2017.
APA
Gong, T., Su, X., Xia, Q., Wang, J., & Kan, S. (2017). Expression of NF-κB and PTEN in osteosarcoma and its clinical significance. Oncology Letters, 14, 6744-6748. https://doi.org/10.3892/ol.2017.6972
MLA
Gong, T., Su, X., Xia, Q., Wang, J., Kan, S."Expression of NF-κB and PTEN in osteosarcoma and its clinical significance". Oncology Letters 14.6 (2017): 6744-6748.
Chicago
Gong, T., Su, X., Xia, Q., Wang, J., Kan, S."Expression of NF-κB and PTEN in osteosarcoma and its clinical significance". Oncology Letters 14, no. 6 (2017): 6744-6748. https://doi.org/10.3892/ol.2017.6972
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