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Article

MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells

  • Authors:
    • Chengwei Qin
    • Yanming Zhao
    • Chunzhi Gong
    • Zhenlin Yang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Medical College of Shandong University, Jinan, Shandong 250012, P.R. China, Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Department of Anesthesiology, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China, Department of General Surgery, Binzhou Medical University Hospital, Binzhou, Shandong 256603, P.R. China
  • Pages: 6969-6975
    |
    Published online on: September 21, 2017
       https://doi.org/10.3892/ol.2017.7021
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Abstract

Breast cancer is the leading cause for cancer‑associated mortality in women. Although great progress has been made in the earlier diagnosis and systemic therapy of patients with breast cancer in recent years, recurrence or distant metastasis continue to present major barriers to the successful treatment of breast cancer. Therefore, fully understanding the molecular mechanisms underlying the progression of breast cancer may be critical for the development of effective therapeutic strategies against breast cancer. The aim of the present study was to explore the expression, function and molecular mechanisms of microRNA‑154 (miR‑154) in human breast cancer. It was demonstrated that miR‑154 was significantly downregulated in breast cancer tissue and cell lines. The restoration of miR‑154 expression suppressed the proliferation, migration and invasion of breast cancer cells. ADAM metallopeptidase domain 9 (ADAM9) was identified as a novel direct target for miR‑154 in breast cancer. It was demonstrated that miR‑154 acted as a tumor suppressor in breast cancer by targeting ADAM9. The results of the present study suggest that the restoration of miR‑154 expression may be an effective therapeutic strategy for the treatment of breast cancer in the future.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Fu SW, Lee W, Coffey C, Lean A, Wu X, Tan X, Man YG and Brem RF: miRNAs as potential biomarkers in early breast cancer detection following mammography. Cell Biosci. 6:62016. View Article : Google Scholar : PubMed/NCBI

3 

Porter P: ‘Westernizing’ women's risks? Breast cancer in lower-income countries. N Engl J Med. 358:213–216. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Beaglehole R and Yach D: Globalisation and the prevention and control of non-communicable disease: The neglected chronic diseases of adults. Lancet. 362:903–908. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Parkin DM and Fernández LM: Use of statistics to assess the global burden of breast cancer. Breast J. 12 Suppl 1:S70–S80. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Badar F, Faruqui ZS, Ashraf A and Uddin N: Third world issues in breast cancer detection. J Pak Med Assoc. 57:137–140. 2007.PubMed/NCBI

7 

Bray F, Ren JS, Masuyer E and Ferlay J: Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 132:1133–1145. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Nakamura S, Yagata H, Ohno S, Yamaguchi H, Iwata H, Tsunoda N, Ito Y, Tokudome N, Toi M, Kuroi K and Suzuki E: Multi-center study evaluating circulating tumor cells as a surrogate for response to treatment and overall survival in metastatic breast cancer. Breast Cancer. 17:199–204. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Gong Y, He T, Yang L, Yang G, Chen Y and Zhang X: The role of miR-100 in regulating apoptosis of breast cancer cells. Sci Rep. 5:116502015. View Article : Google Scholar : PubMed/NCBI

10 

Weigelt B, Peterse JL and van 't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Alonso DF, Ripoll GV, Garona J, Iannucci NB and Gomez DE: Metastasis: Recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 12:1974–1980. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Nilsson I and Hoffmann I: Cell cycle regulation by the Cdc25 phosphatase family. Prog Cell Cycle Res. 4:107–114. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Hydbring P and Badalian-Very G: Clinical applications of microRNAs. F1000Res. 2:1362013.PubMed/NCBI

14 

Gromak N: Intronic microRNAs: A crossroad in gene regulation. Biochem Soc Trans. 40:759–761. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M, et al: MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65:7065–7070. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Kosaka N, Iguchi H and Ochiya T: Circulating microRNA in body fluid: A new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101:2087–2092. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Pichler M and Calin GA: MicroRNAs in cancer: From developmental genes in worms to their clinical application in patients. Br J Cancer. 113:569–573. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Medina PP, Nolde M and Slack FJ: OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature. 467:86–90. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, et al: Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet. 43:371–378. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA and Jones PA: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 9:435–443. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, et al: A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci USA. 105:pp. 13556–13561. 2008; View Article : Google Scholar : PubMed/NCBI

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Ma L, Ma S, Zhao G, Yang L, Zhang P, Yi Q and Cheng S: miR-708/LSD1 axis regulates the proliferation and invasion of breast cancer cells. Cancer Med. 5:684–692. 2016. View Article : Google Scholar : PubMed/NCBI

25 

van Jaarsveld MT, Helleman J, Berns EM and Wiemer EA: MicroRNAs in ovarian cancer biology and therapy resistance. Int J Biochem Cell Biol. 42:1282–1290. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Ni F, Gui Z, Guo Q, Hu Z, Wang X, Chen D and Wang S: Downregulation of miR-362-5p inhibits proliferation, migration and invasion of human breast cancer MCF7 cells. Oncol Lett. 11:1155–1160. 2016.PubMed/NCBI

27 

Zhang Y, Zhang HE and Liu Z: MicroRNA-147 suppresses proliferation, invasion and migration through the AKT/mTOR signaling pathway in breast cancer. Oncol Lett. 11:405–410. 2016.PubMed/NCBI

28 

Kai Y, Qiang C, Xinxin P, Miaomiao Z and Kuailu L: Decreased miR-154 expression and its clinical significance in human colorectal cancer. World J Surg Oncol. 13:1952015. View Article : Google Scholar : PubMed/NCBI

29 

Lin X, Yang Z, Zhang P and Shao G: miR-154 suppresses non-small cell lung cancer growth in vitro and in vivo. Oncol Rep. 33:3053–3060. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Xin C, Zhang H and Liu Z: miR-154 suppresses colorectal cancer cell growth and motility by targeting TLR2. Mol Cell Biochem. 387:271–277. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Zhu C, Shao P, Bao M, Li P, Zhou H, Cai H, Cao Q, Tao L, Meng X, Ju X, et al: miR-154 inhibits prostate cancer cell proliferation by targeting CCND2. Urol Oncol. 32:31.e9–e16. 2014. View Article : Google Scholar

32 

Zhu C, Li J, Cheng G, Zhou H, Tao L, Cai H, Li P, Cao Q, Ju X, Meng X, et al: miR-154 inhibits EMT by targeting HMGA2 in prostate cancer cells. Mol Cell Biochem. 379:69–75. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Blobel CP: ADAMs: Key components in EGFR signalling and development. Nat Rev Mol Cell Biol. 6:32–43. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Edwards DR, Handsley MM and Pennington CJ: The ADAM metalloproteinases. Mol Aspects Med. 29:258–289. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Fritzsche FR, Wassermann K, Jung M, Tölle A, Kristiansen I, Lein M, Johannsen M, Dietel M, Jung K and Kristiansen G: ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression. BMC Cancer. 8:1792008. View Article : Google Scholar : PubMed/NCBI

36 

Fritzsche FR, Jung M, Tölle A, Wild P, Hartmann A, Wassermann K, Rabien A, Lein M, Dietel M, Pilarsky C, et al: ADAM9 expression is a significant and independent prognostic marker of PSA relapse in prostate cancer. Eur Urol. 54:1097–1106. 2008. View Article : Google Scholar : PubMed/NCBI

37 

O'Shea C, McKie N, Buggy Y, Duggan C, Hill AD, McDermott E, O'Higgins N and Duffy MJ: Expression of ADAM-9 mRNA and protein in human breast cancer. Int J Cancer. 105:754–761. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Tao K, Qian N, Tang Y, Ti Z, Song W, Cao D and Dou K: Increased expression of a disintegrin and metalloprotease-9 in hepatocellular carcinoma: Implications for tumor progression and prognosis. Jpn J Clin Oncol. 40:645–651. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Grützmann R, Lüttges J, Sipos B, Ammerpohl O, Dobrowolski F, Alldinger I, Kersting S, Ockert D, Koch R, Kalthoff H, et al: ADAM9 expression in pancreatic cancer is associated with tumour type and is a prognostic factor in ductal adenocarcinoma. Br J Cancer. 90:1053–1058. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Wang S, Wang X, Guo Q, Wang G, Han X, Li X, Shi ZW and He W: MicroRNA-126 overexpression inhibits proliferation and invasion in osteosarcoma cells. Technol Cancer Res Treat. 15:NP49–NP59. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Zhang C, Zhang Y, Ding W, Lin Y, Huang Z and Luo Q: MiR-33a suppresses breast cancer cell proliferation and metastasis by targeting ADAM9 and ROS1. Protein Cell. 6:881–889. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Qin C, Zhao Y, Gong C and Yang Z: MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells. Oncol Lett 14: 6969-6975, 2017.
APA
Qin, C., Zhao, Y., Gong, C., & Yang, Z. (2017). MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells. Oncology Letters, 14, 6969-6975. https://doi.org/10.3892/ol.2017.7021
MLA
Qin, C., Zhao, Y., Gong, C., Yang, Z."MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells". Oncology Letters 14.6 (2017): 6969-6975.
Chicago
Qin, C., Zhao, Y., Gong, C., Yang, Z."MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells". Oncology Letters 14, no. 6 (2017): 6969-6975. https://doi.org/10.3892/ol.2017.7021
Copy and paste a formatted citation
x
Spandidos Publications style
Qin C, Zhao Y, Gong C and Yang Z: MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells. Oncol Lett 14: 6969-6975, 2017.
APA
Qin, C., Zhao, Y., Gong, C., & Yang, Z. (2017). MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells. Oncology Letters, 14, 6969-6975. https://doi.org/10.3892/ol.2017.7021
MLA
Qin, C., Zhao, Y., Gong, C., Yang, Z."MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells". Oncology Letters 14.6 (2017): 6969-6975.
Chicago
Qin, C., Zhao, Y., Gong, C., Yang, Z."MicroRNA‑154/ADAM9 axis inhibits the proliferation, migration and invasion of breast cancer cells". Oncology Letters 14, no. 6 (2017): 6969-6975. https://doi.org/10.3892/ol.2017.7021
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