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Article

ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line

  • Authors:
    • Yang Jiang
    • Hui Li
    • Yi Wang
    • Tian Tian
    • Yan He
    • Yinji Jin
    • Changsong Han
    • Xiaoming Jin
    • Fengmin Zhang
    • Eiichi Morii
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, P.R. China, Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565‑0871, Japan, Department of Microbiology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
  • Pages: 6955-6961
    |
    Published online on: September 25, 2017
       https://doi.org/10.3892/ol.2017.7057
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Abstract

The present study aimed to examine whether the enzyme activity of aldehyde dehydrogenase (ALDH) was regulated by Nodal and histamine in the human alveolar adenocarcinoma A549 cell line. The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma. The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). ALDH activity was also downregulated by recombinant human Nodal and antagonists of H1R and H2R in the A549 cell line. In addition, expression of Nodal and ALDH1 were inversely correlated in lung mixed adenocarcinoma. ALDH enzyme activity was regulated by Nodal and histamine in lung adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, Han C, Jin X, Zhang F, Morii E, Morii E, et al: ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncol Lett 14: 6955-6961, 2017.
APA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y. ... Morii, E. (2017). ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncology Letters, 14, 6955-6961. https://doi.org/10.3892/ol.2017.7057
MLA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14.6 (2017): 6955-6961.
Chicago
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14, no. 6 (2017): 6955-6961. https://doi.org/10.3892/ol.2017.7057
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, Han C, Jin X, Zhang F, Morii E, Morii E, et al: ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncol Lett 14: 6955-6961, 2017.
APA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y. ... Morii, E. (2017). ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncology Letters, 14, 6955-6961. https://doi.org/10.3892/ol.2017.7057
MLA
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14.6 (2017): 6955-6961.
Chicago
Jiang, Y., Li, H., Wang, Y., Tian, T., He, Y., Jin, Y., Han, C., Jin, X., Zhang, F., Morii, E."ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line". Oncology Letters 14, no. 6 (2017): 6955-6961. https://doi.org/10.3892/ol.2017.7057
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