|
1
|
Thomas MB and Zhu AX: Hepatocellular
carcinoma: The need for progress. J Clin Oncol. 23:2892–2899. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Calvisi DF, Ladu S, Gorden A, Farina M,
Lee JS, Conner EA, Schroeder I, Factor VM and Thorgeirsson SS:
Mechanistic and prognostic significance of aberrant methylation in
the molecular pathogenesis of human hepatocellular carcinoma. J
Clin Invest. 117:2713–2722. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
3
|
Altekruse SF, McGlynn KA and Reichman ME:
Hepatocellular carcinoma incidence, mortality, and survival trends
in the United States from 1975 to 2005. J Clin Oncol. 27:1485–1491.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Sia D, Villanueva A, Friedman SL and
Llovet JM: Liver cancer cell of origin, molecular class, and
effects on patient prognosis. Gastroenterology. 152:745–761. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Herzog CE, Andrassy RJ and Eftekhari F:
Childhood cancers: Hepatoblastoma. Oncologist. 5:445–453. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Darbari A, Sabin KM, Shapiro CN and
Schwarz KB: Epidemiology of primary hepatic malignancies in U.S.
Children. Hepatology. 38:560–566. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Llovet JM, Burroughs A and Bruix J:
Hepatocellular carcinoma. Lancet. 362:1907–1917. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Seeff LB: Introduction: The burden of
hepatocellular carcinoma. Gastroenterology. 127(5): S1–S4. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bisteau X, Caldez MJ and Kaldis P: The
complex relationship between liver cancer and the cell cycle: A
story of multiple regulations. Cancers (Basel). 6:79–111. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Thorgeirsson SS and Grisham JW: Molecular
pathogenesis of human hepatocellular carcinoma. Nat Genet.
31:339–346. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Dan YY, Riehle KJ, Lazaro C, Teoh N, Haque
J, Campbell JS and Fausto N: Isolation of multipotent progenitor
cells from human fetal liver capable of differentiating into liver
and mesenchymal lineages. Proc Natl Acad Sci USA. 103:pp.
9912–9917. 2006; View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Bell D, Ranganathan S, Tao J and Monga SP:
Novel Advances in Understanding of Molecular Pathogenesis of
Hepatoblastoma: A Wnt/β-Catenin Perspective. Gene Expr. 17:141–154.
2017. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen
L, Li Q, Huang Y, Zhang Y, Zhang Z, et al: Exome sequencing of
hepatoblastoma reveals novel mutations and cancer genes in the Wnt
pathway and ubiquitin ligase complex. Hepatology. 60:1686–1696.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Eichenmuller M, Trippel F, Kreuder M, Beck
A, Schwarzmayr T, Haberle B, Cairo S, Leuschner I, von Schweinitz
D, Strom TM and Kappler R: The genomic landscape of hepatoblastoma
and their progenies with HCC-like features. J Hepatol.
61:1312–1320. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Koch A, Denkhaus D, Albrecht S, Leuschner
I, von Schweinitz D and Pietsch T: Childhood hepatoblastomas
frequently carry a mutated degradation targeting box of the
beta-catenin gene. Cancer Res. 59:269–273. 1999.PubMed/NCBI
|
|
16
|
Koch A, Weber N, Waha A, Hartmann W,
Denkhaus D, Behrens J, Birchmeier W, von Schweinitz D and Pietsch
T: Mutations and elevated transcriptional activity of conductin
(AXIN2) in hepatoblastomas. J Pathol. 204:546–554. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Tomlinson GE and Kappler R: Genetics and
epigenetics of hepatoblastoma. Pediatr Blood Cancer. 59:785–792.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Liu C, Liu L, Chen X, Shen J, Shan J, Xu
Y, Yang Z, Wu L, Xia F, Bie P, et al: Decrease of
5-hydroxymethylcytosine is associated with progression of
hepatocellular carcinoma through downregulation of TET1. PLoS One.
8:e628282013. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Nishida N and Goel A: Genetic and
epigenetic signatures in human hepatocellular carcinoma: A
systematic review. Curr Genomics. 12:130–137. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Rumbajan JM, Maeda T, Souzaki R, Mitsui K,
Higashimoto K, Nakabayashi K, Yatsuki H, Nishioka K, Harada R, Aoki
S, et al: Comprehensive analyses of imprinted differentially
methylated regions reveal epigenetic and genetic characteristics in
hepatoblastoma. BMC Cancer. 13:6082013. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Cui X, Liu B, Zheng S, Dong K and Dong R:
Genome-wide analysis of DNA methylation in hepatoblastoma tissues.
Oncol Lett. 12:1529–1534. 2016.PubMed/NCBI
|
|
22
|
Majmundar AJ, Wong WJ and Simon MC:
Hypoxia-inducible factors and the response to hypoxic stress. Mol
Cell. 40:294–309. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Semenza GL: Molecular mechanisms mediating
metastasis of hypoxic breast cancer cells. Trends Mol Med.
18:534–543. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Liu Q, Liu L, Zhao Y, Zhang J, Wang D,
Chen J, He Y, Wu J, Zhang Z and Liu Z: Hypoxia induces genomic DNA
demethylation through the activation of HIF-1α and transcriptional
upregulation of MAT2A in hepatoma cells. Mol Cancer Ther.
10:1113–1123. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Shahrzad S, Bertrand K, Minhas K and
Coomber BL: Induction of DNA hypomethylation by tumor hypoxia.
Epigenetics. 2:119–125. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Wu H and Zhang Y: Mechanisms and functions
of Tet protein-mediated 5-methylcytosine oxidation. Genes Dev.
25:2436–2452. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Das PM and Singal R: DNA methylation and
cancer. J Clin Oncol. 22:4632–4642. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Jones PA: Functions of DNA methylation:
Islands, start sites, gene bodies and beyond. Nat Rev Genet.
13:484–492. 2012. View
Article : Google Scholar : PubMed/NCBI
|
|
29
|
Kohli RM and Zhang Y: TET enzymes, TDG and
the dynamics of DNA demethylation. Nature. 502:472–479. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Ito S, Shen L, Dai Q, Wu SC, Collins LB,
Swenberg JA, He C and Zhang Y: Tet proteins can convert
5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
Science. 333:1300–1303. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Tahiliani M, Koh KP, Shen Y, Pastor WA,
Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L and
Rao A: Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in
mammalian DNA by MLL partner TET1. Science. 324:930–935. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Qiu GH, Xie X, Xu F, Shi X, Wang Y and
Deng L: Distinctive pharmacological differences between liver
cancer cell lines HepG2 and Hep3B. Cytotechnology. 67:1–12. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Rikhi RR, Spady KK, Hoffman RI, Bateman
MS, Bateman M and Howard LE: Hepatoblastoma: A Need for Cell Lines
and Tissue Banks to Develop Targeted Drug Therapies. Front Pediatr.
4:222016. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Wang GL and Semenza GL: General
involvement of hypoxia-inducible factor 1 in transcriptional
response to hypoxia. Proc Natl Acad Sci USA. 90:pp. 4304–4308.
1993; View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Pugh CW, O'Rourke JF, Nagao M, Gleadle JM
and Ratcliffe PJ: Activation of hypoxia-inducible factor-1;
definition of regulatory domains within the alpha subunit. J Biol
Chem. 272:11205–11214. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Robertson KD: DNA methylation and human
disease. Nat Rev Genet. 6:597–610. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Gopalakrishnan S, Van Emburgh BO and
Robertson KD: DNA methylation in development and human disease.
Mutat Res. 647:30–38. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
López-Terrada D, Cheung SW, Finegold MJ
and Knowles BB: Hep G2 is a hepatoblastoma-derived cell line. Hum
Pathol. 40:1512–1515. 2009. View Article : Google Scholar
|
|
40
|
Capes-Davis A, Theodosopoulos G, Atkin I,
Drexler HG, Kohara A, MacLeod RA, Masters JR, Nakamura Y, Reid YA,
Reddel RR and Freshney RI: Check your cultures! A list of
cross-contaminated or misidentified cell lines. Int J Cancer.
127:1–8. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Aden DP, Fogel A, Plotkin S, Damjanov I
and Knowles BB: Controlled synthesis of HBsAg in a differentiated
human liver carcinoma-derived cell line. Nature. 282:615–616. 1979.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Ivanov M, Kals M, Kacevska M, Barragan I,
Kasuga K, Rane A, Metspalu A, Milani L and Ingelman-Sundberg M:
Ontogeny, distribution and potential roles of
5-hydroxymethylcytosine in human liver function. Genome Biol.
14:R832013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Yang H, Liu Y, Bai F, Zhang JY, Ma SH, Liu
J, Xu ZD, Zhu HG, Ling ZQ, Ye D, et al: Tumor development is
associated with decrease of TET gene expression and
5-methylcytosine hydroxylation. Oncogene. 32:663–669. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Mariani CJ, Vasanthakumar A, Madzo J,
Yesilkanal A, Bhagat T, Yu Y, Bhattacharyya S, Wenger RH, Cohn SL,
Nanduri J, et al: TET1-mediated hydroxymethylation facilitates
hypoxic gene induction in neuroblastoma. Cell Rep. 7:1343–1352.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Wu MZ, Chen SF, Nieh S, Benner C, Ger LP,
Jan CI, Ma L, Chen CH, Hishida T, Chang HT, et al: Hypoxia Drives
Breast Tumor Malignancy through a TET-TNFα-p38-MAPK Signaling Axis.
Cancer Res. 75:3912–3924. 2015. View Article : Google Scholar : PubMed/NCBI
|
