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Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases

  • Authors:
    • Daniel Hardy Melo
    • Rui Celso Martins Mamede
    • Luciano Neder
    • Wilson Araújo Silva
    • Mateus Camargo Barros‑Filho
    • Luiz Paulo Kowalski
    • Clóvis Antonio Lopes Pinto
    • Marco Antônio Zago
    • David Livingstone Alves Figueiredo
    • Achim A. Jungbluth
  • View Affiliations / Copyright

    Affiliations: School of Medicine, Federal University of Ceara, Sobral, CE 62042‑280, Brazil, Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Center for Cell Based Therapy, CEPID/FAPESP, Ribeirão Preto, SP 14049‑900, Brazil, Department of Clinical Pathology, Ribeirão Preto Medical School, University of São Paulo, Center for Cell Based Therapy, CEPID/FAPESP, Ribeirão Preto, SP 14049‑900, Brazil, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Center for Cell Based Therapy, CEPID/FAPESP, Ribeirão Preto, SP 14049‑900, Brazil, Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, SP 01509‑010, Brazil, Department of Anatomical Pathology, A.C. Camargo Cancer Center, São Paulo, SP 01509‑010, Brazil, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP 14049‑900, Brazil, Department of Pharmacy, Midwestern State University/UNICENTRO, Guarapuava, PR 85040-080, Brazil, Division of Pathology Diagnostic Services, Cytology, Memorial Sloan‑Kettering Cancer Center, New York, NY 10021, USA
    Copyright: © Melo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6485-6496
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    Published online on: September 26, 2017
       https://doi.org/10.3892/ol.2017.7072
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Abstract

Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high‑grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma‑associated antigen (MAGE) A, MAGE‑C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry. None of the CT antigens were expressed in the normal thyroid or goiter. In papillary and follicular carcinoma, MAGE‑A was present in 8.1% of cases, GAGE in 10.8% and CT/7MAGE‑C1 and CTAG1B in 2.7% each. In medullary carcinoma, CT antigen expression was as follows: MAGE‑A in 42.9% of patients; MAGE‑C1/CT7 in 46.5%; GAGE in 92.9%; and CTAG1B in 3.6%. A statistically significant association was observed between the expression of G MAGE‑C1/CT7 and patient gender as well as patient clinical stage (P=0.029 and 0.031, respectively). In poorly differentiated and anaplastic carcinoma cases, CT antigen expression was as follows: MAGE‑A in 61.8% of cases; MAGE‑C1 in 57.1%; GAGE in 66.7%; and CTAG1B in 14.4%. There was a statistically significant association between expression of GAGE and gender (P=0.043). However, there was no association between CT antigen expression and patient survival in any of the tumor entities analyzed. The current study identified a distinct expression pattern of CT antigens in malignant thyroid tumors indicating that CT antigens have the potential to outperform existing thyroid cancer biomarkers. The prevalence of CT antigens in high‑grade carcinomas suggests that they serve an important biological role within malignant tumors.
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1 

Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Sherman SI and Tuttle RM: American Thyroid Association Guidelines Taskforce: Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 16:109–142. 2006. View Article : Google Scholar : PubMed/NCBI

2 

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, ; Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, et al: Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 19:1167–1214. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Tan GH and Gharib H: Thyroid incidentalomas: Management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern Med. 126:226–231. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Singer PA, Cooper DS, Daniels GH, Ladenson PW, Greenspan FS, Levy EG, Braverman LE, Clark OH, McDougall IR, Ain KV and Dorfman SG: Treatment guidelines for patients with thyroid nodules and well-differentiated thyroid cancer. American thyroid association. Arch Intern Med. 156:2165–2172. 1996. View Article : Google Scholar : PubMed/NCBI

5 

Ito Y, Kudo T, Kobayashi K, Miya A, Ichihara K and Miyauchi A: Prognostic factors for recurrence of papillary thyroid carcinoma in the lymph nodes, lung and bone: Analysis of 5,768 patients with average 10-year follow-up. World J Surg. 36:1274–1278. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Huang IC, Chou FF, Liu RT, Tung SC, Chen JF, Kuo MC, Hsieh CJ and Wang PW: Long-term outcomes of distant metastasis from differentiated thyroid carcinoma. Clin Endocrinol (Oxf). 76:439–447. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Konturek A, Barczyński M, Nowak W and Richter P: Prognostic factors in differentiated thyroid cancer-a 20-year surgical outcome study. Langenbecks Arch Surg. 397:809–815. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Cheung CC, Carydis B, Ezzat S, Bedard YC and Asa SL: Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer. J Clin Endocrinol Metab. 86:2187–2190. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Pizzolanti G, Russo L, Richiusa P, Bronte V, Nuara RB, Rodolico V, Amato MC, Smeraldi L, Sisto PS, Nucera M, et al: Fine-needle aspiration molecular analysis for the diagnosis of papillary thyroid carcinoma through BRAF V600E mutation and RET/PTC rearrangement. Thyroid. 17:1109–1115. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Faggiano A, Caillou B, Lacroix L, Talbot M, Filetti S, Bidart JM and Schlumberger M: Functional characterization of human thyroid tissue with immunohistochemistry. Thyroid. 17:203–211. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Beatty PL, Cascio S and Lutz E: Tumor immunology: Basic and clinical advances. Cancer Res. 71:4338–4343. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Boon T and Old LJ: Cancer tumor antigens. Curr Opin Immunol. 9:681–683. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Scanlan MJ, Gure AO, Jungbluth AA, Old LJ and Chen YT: Cancer/testis antigens: An expanding family of targets for cancer immunotherapy. Immunol Rev. 188:22–32. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Scanlan MJ, Simpson AJ and Old LJ: The cancer/testis genes: Review, standardization, and commentary. Cancer Immun. 4:12004.PubMed/NCBI

15 

Simpson AJ, Caballero OL, Jungbluth A, Chen YT and Old LJ: Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer. 5:615–625. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Bodey B: Cancer-testis antigens: Promising targets for antigen directed antineoplastic immunotherapy. Expert Opin Biol Ther. 2:577–584. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Fratta E, Coral S, Covre A, Parisi G, Colizzi F, Danielli R, Nicolay HJ, Sigalotti L and Maio M: The biology of cancer testis antigens: Putative function, regulation and therapeutic potential. Mol Oncol. 5:164–182. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Jungbluth AA, Stockert E, Chen YT, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Busam KJ and Old LJ: Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours. Br J Cancer. 83:493–497. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Landry C, Brasseur F, Spagnoli GC, Marbaix E, Boon T, Coulie P and Godelaine D: Monoclonal antibody 57B stains tumor tissues that express gene MAGE-A4. Int J Cancer. 86:835–841. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Rimoldi D, Salvi S, Schultz-Thater E, Spagnoli GC and Cerottini JC: Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family. Int J Cancer. 86:749–751. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Milkovic M, Sarcevic B and Glavan E: Expression of MAGE tumor-associated antigen in thyroid carcinomas. Endocr Pathol. 17:45–52. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Inaoka RJ, Jungbluth AA, Baiocchi OC, Assis MC, Hanson NC, Frosina D, Tassello J, Bortoluzzo AB, Alves AC and Colleoni GW: An overview of cancer/testis antigens expression in classical Hodgkin's lymphoma (cHL) identifies MAGE-A family and MAGE-C1 as the most frequently expressed antigens in a set of Brazilian cHL patients. BMC Cancer. 11:4162011. View Article : Google Scholar : PubMed/NCBI

23 

Jungbluth AA, Busam KJ, Kolb D, Iversen K, Coplan K, Chen YT, Spagnoli GC and Old LJ: Expression of MAGE-antigens in normal tissues and cancer. Int J Cancer. 85:460–465. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Krishnadas DK, Shusterman S, Bai F, Diller L, Sullivan JE, Cheerva AC, George RE and Lucas KG: A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma. Cancer Immunol Immunother. 64:1251–1260. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Jungbluth AA, Chen YT, Busam KJ, Coplan K, Kolb D, Iversen K, Williamson B, Van Landeghem FK, Stockert E and Old LJ: CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues. Int J Cancer. 99:839–845. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Curioni-Fontecedro A, Knights AJ, Tinguely M, Nuber N, Schneider C, Thomson CW, von Boehmer L, Bossart W, Pahlich S, Gehring H, et al: MAGE-C1/CT7 is the dominant cancer-testis antigen targeted by humoral immune responses in patients with multiple myeloma. Leukemia. 22:1646–1648. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Curioni-Fontecedro A, Nuber N, Mihic-Probst D, Seifert B, Soldini D, Dummer R, Knuth A, van den Broek M and Moch H: Expression of MAGE-C1/CT7 and MAGE-C2/CT10 predicts lymph node metastasis in melanoma patients. PLoS One. 6:e214182011. View Article : Google Scholar : PubMed/NCBI

28 

Jungbluth AA, Chen YT, Stockert E, Busam KJ, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N and Old LJ: Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues. Int J Cancer. 92:856–860. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Gjerstorff MF, Pøhl M, Olsen KE and Ditzel HJ: Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma. BMC Cancer. 13:4662013. View Article : Google Scholar : PubMed/NCBI

30 

Ademuyiwa FO, Bshara W, Attwood K, Morrison C, Edge SB, Karpf AR, James SA, Ambrosone CB, O'Connor TL, Levine EG, et al: NY-ESO-1 cancer testis antigen demonstrates high immunogenicity in triple negative breast cancer. PLoS One. 7:e387832012. View Article : Google Scholar : PubMed/NCBI

31 

Robbins PF, Morgan RA, Feldman SA, Yang JC, Sherry RM, Dudley ME, Wunderlich JR, Nahvi AV, Helman LJ, Mackall CL, et al: Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1. J Clin Oncol. 29:917–924. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Cilensek ZM, Yehiely F, Kular RK and Deiss LP: A member of the GAGE family of tumor antigens is an anti-apoptotic gene that confers resistance to Fas/CD95/APO-1, interferon-gamma, taxol and gamma-irradiation. Cancer Biol Ther. 1:380–387. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Gnjatic S, Nishikawa H, Jungbluth AA, Güre AO, Ritter G, Jäger E, Knuth A, Chen YT and Old LJ: NY-ESO-1: Review of an immunogenic tumor antigen. Adv Cancer Res. 95:1–30. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Curigliano G, Viale G, Ghioni M, Jungbluth AA, Bagnardi V, Spagnoli GC, Neville AM, Nolè F, Rotmensz N and Goldhirsch A: Cancer-testis antigen expression in triple-negative breast cancer. Ann Oncol. 22:98–103. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Zhuang R, Zhu Y, Fang L, Liu XS, Tian Y, Chen LH, Ouyang WM, Xu XG, Jian JL, Güre AO, et al: Generation of monoclonal antibodies to cancer/testis (CT) antigen CT10/MAGE-C2. Cancer Immun. 6:72006.PubMed/NCBI

36 

Sharma P, Shen Y, Wen S, Bajorin DF, Reuter VE, Old LJ and Jungbluth AA: Cancer-testis antigens: Expression and correlation with survival in human urothelial carcinoma. Clin Cancer Res. 12:5442–5447. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Jungbluth AA, Silva WA Jr, Iversen K, Frosina D, Zaidi B, Coplan K, Eastlake-Wade SK, Castelli SB, Spagnoli GC, Old LJ and Vogel M: Expression of cancer-testis (CT) antigens in placenta. Cancer Immun. 7:152007.PubMed/NCBI

38 

Grigoriadis A, Caballero OL, Hoek KS, da Silva L, Chen YT, Shin SJ, Jungbluth AA, Miller LD, Clouston D, Cebon J, et al: CT-X antigen expression in human breast cancer. Proc Natl Acad Sci USA. 106:pp. 13493–13498. 2009; View Article : Google Scholar : PubMed/NCBI

39 

Cheng S, Liu W, Mercado M, Ezzat S and Asa SL: Expression of the melanoma-associated antigen is associated with progression of human thyroid cancer. Endocr Relat Cancer. 16:455–466. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Noguchi T, Kato T, Wang L, Maeda Y, Ikeda H, Sato E, Knuth A, Gnjatic S, Ritter G, Sakaguchi S, et al: Intracellular tumor-associated antigens represent effective targets for passive immunotherapy. Cancer Res. 72:1672–1682. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Inaoka RJ, Jungbluth AA, Gnjatic S, Ritter E, Hanson NC, Frosina D, Tassello J, Etto LY, Bortoluzzo AB, Alves AC and Colleoni GW: Cancer/testis antigens expression and autologous serological response in a set of Brazilian non-Hodgkin's lymphoma patients. Cancer Immunol Immunother. 61:2207–2214. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Melo DH, Mamede RC, Neder L, Saggioro FP, Figueiredo DL, da Silva WA Jr, Jungbluth AA and Zago MA: Expression of MAGE-A4 and MAGE-C1 tumor-associated antigen in benign and malignant thyroid diseases. Head Neck. 33:1426–1432. 2011. View Article : Google Scholar : PubMed/NCBI

43 

Sigalotti L, Covre A, Nicolay HJ, Coral S and Maio M: Cancer testis antigens and melanoma stem cells: New promises for therapeutic intervention. Cancer Immunol Immunother. 59:487–488. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Saldanha-Araujo F, Haddad R, Zanette DL, De Araujo AG, Orellana MD, Covas DT, Zago MA and Panepucci RA: Cancer/Testis antigen expression on mesenchymal stem cells isolated from different tissues. Anticancer Res. 30:5023–5017. 2010.PubMed/NCBI

45 

Chen YT, Ross DS, Chiu R, Zhou XK, Chen YY, Lee P, Hoda SA, Simpson AJ, Old LJ, Caballero O and Neville AM: Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers. PLoS One. 6:e178762011. View Article : Google Scholar : PubMed/NCBI

46 

Gunda V, Frederick DT, Bernasconi MJ, Wargo JA and Parangi S: A potential role for immunotherapy in thyroid cancer by enhancing NY-ESO-1 cancer antigen expression. Thyroid. 24:1241–1250. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Tinguely M, Jenni B, Knights A, Lopes B, Korol D, Rousson V, Fontecedro A Curioni, Cogliatti SB, Bittermann AG, Schmid U, et al: MAGE-C1/CT-7 expression in plasma cell myeloma: Sub-cellular localization impacts on clinical outcome. Cancer Sci. 99:720–725. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Barrow C, Browning J, MacGregor D, Davis ID, Sturrock S, Jungbluth AA and Cebon J: Tumor antigen expression in melanoma varies according to antigen and stage. Clin Cancer Res. 12:764–771. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Groeper C, Gambazzi F, Zajac P, Bubendorf L, Adamina M, Rosenthal R, Zerkowski HR, Heberer M and Spagnoli GC: Cancer/testis antigen expression and specific cytotoxic T lymphocyte responses in non small cell lung cancer. Int J Cancer. 120:337–343. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Atanackovic D, Arfsten J, Cao Y, Gnjatic S, Schnieders F, Bartels K, Schilling G, Faltz C, Wolschke C, Dierlamm J, et al: Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. Blood. 109:1103–1112. 2007. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Melo DH, Mamede RC, Neder L, Silva WA, Barros‑Filho MC, Kowalski LP, Pinto CA, Zago MA, Figueiredo DL, Jungbluth AA, Jungbluth AA, et al: Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases. Oncol Lett 14: 6485-6496, 2017.
APA
Melo, D.H., Mamede, R.C., Neder, L., Silva, W.A., Barros‑Filho, M.C., Kowalski, L.P. ... Jungbluth, A.A. (2017). Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases. Oncology Letters, 14, 6485-6496. https://doi.org/10.3892/ol.2017.7072
MLA
Melo, D. H., Mamede, R. C., Neder, L., Silva, W. A., Barros‑Filho, M. C., Kowalski, L. P., Pinto, C. A., Zago, M. A., Figueiredo, D. L., Jungbluth, A. A."Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases". Oncology Letters 14.6 (2017): 6485-6496.
Chicago
Melo, D. H., Mamede, R. C., Neder, L., Silva, W. A., Barros‑Filho, M. C., Kowalski, L. P., Pinto, C. A., Zago, M. A., Figueiredo, D. L., Jungbluth, A. A."Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases". Oncology Letters 14, no. 6 (2017): 6485-6496. https://doi.org/10.3892/ol.2017.7072
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Spandidos Publications style
Melo DH, Mamede RC, Neder L, Silva WA, Barros‑Filho MC, Kowalski LP, Pinto CA, Zago MA, Figueiredo DL, Jungbluth AA, Jungbluth AA, et al: Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases. Oncol Lett 14: 6485-6496, 2017.
APA
Melo, D.H., Mamede, R.C., Neder, L., Silva, W.A., Barros‑Filho, M.C., Kowalski, L.P. ... Jungbluth, A.A. (2017). Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases. Oncology Letters, 14, 6485-6496. https://doi.org/10.3892/ol.2017.7072
MLA
Melo, D. H., Mamede, R. C., Neder, L., Silva, W. A., Barros‑Filho, M. C., Kowalski, L. P., Pinto, C. A., Zago, M. A., Figueiredo, D. L., Jungbluth, A. A."Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases". Oncology Letters 14.6 (2017): 6485-6496.
Chicago
Melo, D. H., Mamede, R. C., Neder, L., Silva, W. A., Barros‑Filho, M. C., Kowalski, L. P., Pinto, C. A., Zago, M. A., Figueiredo, D. L., Jungbluth, A. A."Expression of cancer/testis antigens MAGE‑A, MAGE‑C1, GAGE and CTAG1B in benign and malignant thyroid diseases". Oncology Letters 14, no. 6 (2017): 6485-6496. https://doi.org/10.3892/ol.2017.7072
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