Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer

  • Authors:
    • Yi Ouyang
    • Yanhong Wang
    • Kai Chen
    • Xinping Cao
    • Yiming Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Sun Yat‑Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Radiotherapy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China, Respiratory Department, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China
    Copyright: © Ouyang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7069-7076
    |
    Published online on: September 27, 2017
       https://doi.org/10.3892/ol.2017.7077
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to evaluate the distinctions in survival and toxicity between patients with cervical cancer with common iliac node or para‑aortic node involvement, who were treated with extended‑field intensity‑modulated radiotherapy (EF‑IMRT) and patients with or without lower involved pelvic nodes, who were treated with pelvic IMRT. A total of 55 patients treated with EF‑IMRT and 52 patients treated with pelvic IMRT at the Sun Yat‑Sen University Cancer Center (Guangzhou, China) were retrospectively analyzed. Patients treated with EF‑IMRT had the highest level of lymph node involvement to the para‑aortic or common iliac nodes, while patients treated with pelvic IMRT had no para‑aortic or common iliac nodes involved (P<0.001). The median follow‑up time was 29.5 months. The 3‑year overall survival (OS) rates of EF‑IMRT and pelvic IMRT were 79.4 and 82.3% (P=0.45), respectively, and the 3‑year disease‑free survival (DFS) rates of EF‑IMRT and pelvic IMRT were 61.0 and 73.7% (P=0.55), respectively. Cox's regression analysis revealed that EF irradiation was a protective prognostic factor for OS and DFS. A total of 16 patients in the EF‑IMRT group and 13 patients in the pelvic IMRT group experienced treatment failure (P=0.67), with the patterns of failure being the same for the two groups (P=0.88). The cumulative incidence of grade 3 and 4 acute toxicities in the EF‑IMRT group was 34.5%, in comparison with 19.2% in the pelvic group (P=0.048). The results of the present study suggest that patients with cervical cancer with grossly involved common iliac or para‑aortic nodes should be electively subjected to EF irradiation to improve the survival and alter patterns of recurrence. Notably, EF irradiation delivered via IMRT exhibits an increased toxicity incidence, however, this remains within an acceptable range.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lin MY, Jobling TW and Narayan K: Surgical staging of para-aortic LN in patients with locally advanced cervix cancer and no evidence of metastases in preoperative PET/CT imaging. J Gynecol Oncol. 26:352–354. 2015. View Article : Google Scholar : PubMed/NCBI

2 

FIGO Committee on Gynecologic Oncology: FIGO staging for carcinoma of the vulva, cervix, and corpus uteri. Int J Gynaecol Obstet. 125:97–98. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kidd EA, Siegel BA, Dehdashti F, Rader JS, Mutch DG, Powell MA and Grigsby PW: Lymph node staging by positron emission tomography in cervical cancer: Relationship to prognosis. J Clin Oncol. 28:2108–2113. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Rotman M, Pajak TF, Choi K, Clery M, Marcial V, Grigsby PW, Cooper J and John M: Prophylactic extended-field irradiation of para-aortic lymph nodes in stages IIB and bulky IB and IIA cervical carcinomas. Ten-year treatment results of RTOG 79–20. JAMA. 274:387–393. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Gay HA, Barthold HJ, O'Meara E, Bosch WR, El Naqa I, Al-Lozi R, Rosenthal SA, Lawton C, Lee WR, Sandler H, et al: Pelvic normal tissue contouring guidelines for radiation therapy: A radiation therapy oncology group consensus panel atlas. Int J Radiat Oncol Biol Phys. 83:e353–e362. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lim K, Small W Jr, Portelance L, Creutzberg C, Jürgenliemk-Schulz IM, Mundt A, Mell LK, Mayr N, Viswanathan A, Jhingran A, et al: Consensus guidelines for delineation of clinical target volume for intensity-modulated pelvic radiotherapy for the definitive treatment of cervix cancer. Int J Radiat Oncol Biol Phys. 79:348–355. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Kabolizadeh P, Fulay S and Beriwal S: Are radiation therapy oncology group para-aortic contouring guidelines for pancreatic neoplasm applicable to other malignancies-assessment of nodal distribution in gynecological malignancies. Int J Radiat Oncol Biol Phys. 87:106–110. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the eastern cooperative oncology group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

9 

Cox JD, Stetz J and Pajak TF: Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1341–1346. 1995. View Article : Google Scholar : PubMed/NCBI

10 

Salama JK, Mundt AJ, Roeske J and Mehta N: Preliminary outcome and toxicity report of extended-field, intensity-modulated radiation therapy for gynecologic malignancies. Int J Radiat Oncol Biol Phys. 65:1170–1176. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Yoon HI, Cha J, Keum KC, Lee HY, Nam EJ, Kim SW, Kim S, Kim YT, Kim GE and Kim YB: Treatment outcomes of extended-field radiation therapy and the effect of concurrent chemotherapy on uterine cervical cancer with para-aortic lymph node metastasis. Radiat Oncol. 10:182015. View Article : Google Scholar : PubMed/NCBI

12 

Wu SY, Huang EY, Chanchien CC, Lin H, Wang CJ, Sun LM, Chen HC, Fang FM, Hsu HC and Huang YJ: Prognostic factors associated with radiotherapy for cervical cancer with computed tomography-detected para-aortic lymph node metastasis. J Radiat Res. 55:129–138. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Rajasooriyar C, Van Dyk S, Bernshaw D, Kondalsamy-Chennakesavan S, Barkati M and Narayan K: Patterns of failure and treatment-related toxicity in advanced cervical cancer patients treated using extended field radiotherapy with curative intent. Int J Radiat Oncol Biol Phys. 80:422–428. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Coulombe G, Thiessen B, Balkwill S and Aquino-Parsons C: Polyradiculopathy post-concomitant chemoradiation for carcinoma of the uterine cervix treated with pelvic and para-aortic fields. Gynecol Oncol. 99:774–777. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Ahmed RS, Kim RY, Duan J, Meleth S, De Los Santos JF and Fiveash JB: IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk. Int J Radiat Oncol Biol Phys. 60:505–512. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Boyle J, Craciunescu O, Steffey B, Cai J and Chino J: Methods, safety and early clinical outcomes of dose escalation using simultaneous integrated and sequential boosts in patients with locally advanced gynecologic malignancies. Gynecol Oncol. 135:239–243. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Grigsby PW, Siegel BA and Dehdashti F: Lymph node staging by positron emission tomography in patients with carcinoma of the cervix. J Clin Oncol. 19:3745–3749. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Sakurai H, Mitsuhashi N, Takahashi M, Akimoto T, Muramatsu H, Ishikawa H, Imai R, Yamakawa M, Hasegawa M and Niibe H: Analysis of recurrence of squamous cell carcinoma of the uterine cervix after definitive radiation therapy alone: Patterns of recurrence, latent periods, and prognosis. Int J Radiat Oncol Biol Phys. 50:1136–1144. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Gerszten K, Colonello K, Heron DE, Lalonde RJ, Fitian ID, Comerci JT, Selvaraj RN and Varlotto JM: Feasibility of concurrent cisplatin and extended field radiation therapy (EFRT) using intensity-modulated radiotherapy (IMRT) for carcinoma of the cervix. Gynecol Oncol. 102:182–188. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Beriwal S, Gan GN, Heron DE, Selvaraj RN, Kim H, Lalonde R, Kelley JL and Edwards RP: Early clinical outcome with concurrent chemotherapy and extended-field, intensity-modulated radiotherapy for cervical cancer. Int J Radiat Oncol Biol Phys. 68:166–171. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ouyang Y, Wang Y, Chen K, Cao X and Zeng Y: Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer. Oncol Lett 14: 7069-7076, 2017.
APA
Ouyang, Y., Wang, Y., Chen, K., Cao, X., & Zeng, Y. (2017). Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer. Oncology Letters, 14, 7069-7076. https://doi.org/10.3892/ol.2017.7077
MLA
Ouyang, Y., Wang, Y., Chen, K., Cao, X., Zeng, Y."Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer". Oncology Letters 14.6 (2017): 7069-7076.
Chicago
Ouyang, Y., Wang, Y., Chen, K., Cao, X., Zeng, Y."Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer". Oncology Letters 14, no. 6 (2017): 7069-7076. https://doi.org/10.3892/ol.2017.7077
Copy and paste a formatted citation
x
Spandidos Publications style
Ouyang Y, Wang Y, Chen K, Cao X and Zeng Y: Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer. Oncol Lett 14: 7069-7076, 2017.
APA
Ouyang, Y., Wang, Y., Chen, K., Cao, X., & Zeng, Y. (2017). Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer. Oncology Letters, 14, 7069-7076. https://doi.org/10.3892/ol.2017.7077
MLA
Ouyang, Y., Wang, Y., Chen, K., Cao, X., Zeng, Y."Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer". Oncology Letters 14.6 (2017): 7069-7076.
Chicago
Ouyang, Y., Wang, Y., Chen, K., Cao, X., Zeng, Y."Clinical outcome of extended‑field irradiation vs. pelvic irradiation using intensity‑modulated radiotherapy for cervical cancer". Oncology Letters 14, no. 6 (2017): 7069-7076. https://doi.org/10.3892/ol.2017.7077
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team