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Article

Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway

Corrigendum in: /10.3892/ol.2021.12676
Corrigendum in: /10.3892/ol.2024.14753
  • Authors:
    • Shuming Lu
    • Zhuqing Zhang
    • Meiru Chen
    • Chunyan Li
    • Lina Liu
    • Yan Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Pathology, Dalian Municipal Central Hospital, Dalian, Liaoning 116033, P.R. China, Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 7577-7582
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    Published online on: September 27, 2017
       https://doi.org/10.3892/ol.2017.7080
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Abstract

The objective of the present study was to observe the effects of silibinin and the p38 mitogen‑activated protein kinase (MAPK) signaling pathway inhibitor SB203580 on the migration and invasion capabilities of SGC7901 cells, and to explore the underlying associated mechanisms. Scratch, Transwell and Matrigel invasion assays were performed to study the effects of silibinin on cell migration and invasion. Western blot analysis was used to determine the expression levels of p38MAPK, phosphorylated (p‑)p38MAPK, matrix metalloproteinase (MMP)‑2 and MMP‑9. At the genomic level, quantitative polymerase chain reaction was performed to evaluate the expression levels of MMP‑2 and MMP‑9. The results of scratch assay indicated that silibinin inhibited the migration capabilities of human gastric cancer SGC7901 cells in a dose‑dependent manner. Additionally, Matrigel invasion and Transwell migration assays revealed that silibinin and SB203580 combined treatment significantly reduced the number of invasive cells. Western blot analysis indicated a reduced phosphorylation of p38MAPK without marked changes in p38MAPK expression. In addition, the expression of MMP‑2 and MMP‑9 significantly decreased in the presence of silibinin, SB203580, and the combination of silibinin and SB203580. In summary, silibinin decreased the invasion and migration abilities of SGC7901 cells by downregulating the expression of MMP‑2 and MMP‑9 through inhibiting p38MAPK signaling cascades.
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1 

Mazzocca A and Carloni V: The metastatic process: Methodological advances and pharmacological challenges. Curr Med Chem. 16:1704–1717. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Bravo-Cordero JJ, Hodgson L and Condeelis J: Directed cell invasion and migration during metastasis. Curr Opin Cell Biol. 24:277–283. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Hulkower KI and Herber RL: Cell migration and invasion assays as tools for drug discovery. Pharmaceutics. 3:107–124. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Loukopoulos P, Mungall BA, Straw RC, Thornton JR and Robinson WF: Matrix metalloproteinase-2 and −9 involvement in canine tumors. Vet Pathol. 40:382–394. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Kessenbrock K, Plaks V and Werb Z: Matrix metalloproteinases: Regulators of the tumor microenvironment. Cell. 141:52–67. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Kim EK and Choi EJ: Pathological roles of MAPK signaling pathways in human diseases. Biochim Biophys Acta. 1802:396–405. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Koul HK, Pal M and Koul S: Role of p38 MAP kinase signal transduction in solid tumors. Genes Cancer. 4:342–359. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Dolado I and Nebreda AR: Regulation of tumorigenesis by p38 MAP kinase. Topics Curr Genet. 20:99–128. 2008. View Article : Google Scholar

9 

Emerling BM, Platanias LC, Black E, Nebreda AR, Davis RJ and Chandel NS: Mitochondrial reactive oxygen species activation of p38 mitogen-activated protein kinase is required for hypoxia signaling. Mol Cell Biol. 25:4853–4862. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Lee KH, Kim SW and Kim JR: Reactive oxygen species regulate urokinase plasminogen activator expression and cell invasion via mitogen-activated protein kinase pathways after treatment with hepatocyte growth factor in stomach cancer cells. J Exp Clin Cancer Res. 28:732009. View Article : Google Scholar : PubMed/NCBI

11 

Boukerche H, Aissaoui H, Prévost C, Hirbec H, Das SK, Su ZZ, Sarkar D and Fisher PB: Src kinase activation is mandatory for MDA-9/syntenin-mediated activation of nuclear factor-kappaB. Oncogene. 29:3054–3066. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, et al: Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer. 8:3752008. View Article : Google Scholar : PubMed/NCBI

13 

Chou RH, Hsieh SC, Yu YL, Huang MH, Huang YC and Hsieh YH: Fisetin inhibits migration and invasion of human cervical cancer cells by down-regulating urokinase plasminogen activator expression through suppressing the p38 MAPK-dependent NF-kB signaling pathway. PLoS One. 8:e719832013. View Article : Google Scholar : PubMed/NCBI

14 

Peng CY, Yang HW, Chu YH, Chang YC, Hsieh MJ, Chou MY, Yeh KT, Lin YM, Yang SF and Lin CW: Caffeic Acid phenethyl ester inhibits oral cancer cell metastasis by regulating matrix metalloproteinase-2 and the mitogen-activated protein kinase pathway. Evid Based Complement Alternat Med. 2012:7325782012. View Article : Google Scholar : PubMed/NCBI

15 

Wang XF, Zhou QM, Du J, Zhang H, Lu YY and Su SB: Baicalin suppresses migration, invasion and metastasis of breast cancer via p38MAPK signaling pathway. Anticancer Agents Med Chem. 13:923–931. 2013. View Article : Google Scholar : PubMed/NCBI

16 

DE Oliveira DT, Savio AL, Marcondes JP, Barros TM, Barbosa LC, Salvadori DM and DA Silva GN: Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status. J Biosci. 42:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Polachi N, Bai G, Li T, Chu Y, Wang X, Li S, Gu N, Wu J, Li W, Zhang Y, et al: Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer-A comprehensive review. Eur J Med Chem. 123:577–595. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Jahanafrooz Z, Motameh N and Bakhshandeh B: Comparative evaluation of Silibinin effects on cell cycling and apoptosis in human breast cancer MCF-7 and T47D cell lines. Asian Pac J Cancer Prev. 17:2661–2665. 2016.PubMed/NCBI

19 

Chang HR, Chen PN, Yang SF, Sun YS, Wu SW, Hung TW, Lian JD, Chu SC and Hsieh YS: Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel. Mol Carcinog. 50:811–823. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Lali FV, Hunt AE, Turner SJ and Foxwell BM: The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 275:7395–7402. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Birkenkamp KU, Tuyt LM, Lummen C, Wierenga AT, Kruijer W and Vellenga E: The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway. Br J Pharmacol. 131:99–107. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Barancik M, Htun P, Strohm C, Kilian S and Schaper W: Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death. J Cardiovasc Pharmacol. 35:474–483. 2000. View Article : Google Scholar : PubMed/NCBI

23 

Jin N, Wang Q, Zhang X, Jiang D, Cheng H and Zhu K: The selective p38 mitogen-activated protein kinase inhibitor, SB203580, improves renal disease in MRL/lpr mouse model of systemic lupus. Int Immunopharmacol. 11:1319–1326. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Zhang H, Wu S and Xing D: YAP accelerates A(25–35)-induced apoptosis through upregulation of Bax expression by interaction with p73. Apoptosis. 16:808–821. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Lali FV, Hunt AE, Turner SJ and Foxwell BM: The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase. J Biol Chem. 275:7395–7402. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Wu KJ, Zeng J, Zhu GD, Zhang LL, Zhang D, Li L, Fan JH, Wang XY and He DL: Silibinin inhibits prostate cancer invasion, motility and migration by suppressing vimentin and MMP-2 expression. Acta Pharmacol Sin. 30:1162–1168. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Dastpeyman M, Motamed N, Azadmanesh K, Mostafavi E, Kia V, Jahanian-Najafabadi A and Shokrgozar MA: Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of 1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI. Med Oncol. 29:2512–2518. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Gialeli C, Theocharis AD and Karamanos NK: Roles of matrix metall oproteinases in cancer progression and their pharmacological targeting. FEBS J. 278:16–27. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Kleiner DE and Stetler-Stevenson WG: Matrix metalloproteinases and metastasis. Cancer Chemother Pharmacol. 43 Suppl:S42–S51. 1999. View Article : Google Scholar : PubMed/NCBI

30 

Hidalgo M and Eckhardt SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 93:178–193. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Gerstein ES, Sini L, Ryabov AB, Dvorova EK, Yurchenko AA, Stilidi IS, Kushlinskii NE and Davydov MI: Comparative enzyme immunoassay of matrix metalloproteinases-2,-7,-9 and their tissue inhibitor-2 in tumors and plasma of patients with gastric cancer. Bull Exp Biol Med. 148:899–902. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Sampieri CL, de la Peña S, Ochoa-Lara M, Zenteno-Cuevas R and León-Córdoba K: Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis. World J Gastroenterol. 16:1500–1505. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Weng Y, Cai M, Zhu J, Geng J, Zhu K, Jin X and Ding W: Matrix metalloproteinase activity in early-stage lung cancer. Onkologie. 36:256–259. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Dragutinović VV, Radonjić NV, Petronijević ND, Tatić SB, Dimitrijević IB, Radovanović NS and Krivokapić ZV: Matrix metalloproteinase-2 (MMP-2) and −9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer. Mol Cell Biochem. 355:173–178. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Li Y, Ma J, Guo Q, Duan F, Tang F, Zheng P, Zhao Z and Lu G: Overexpression of MMP-2 and MMP-9 in esophageal squamous cell carcinoma. Dis Esophagus. 22:664–667. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Bradham C and McClay DR: p38 MAPK in development and cancer. Cell Cycle. 5:824–828. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Huang C, Jacobson K and Schaller MD: MAP kinases and migration. J Cell Sci. 117:4619–4628. 2004. View Article : Google Scholar : PubMed/NCBI

38 

Wang ZS, Luo P, Dai SH, Liu ZB, Zheng XR and Chen T: Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation. Cell Mol Neurobiol. 33:921–928. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Pan F, Ma S, Cao W, Liu H, Chen F, Chen X and Shi R: SDF-1 upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines. Mol Biol Rep. 40:4139–4146. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu S, Zhang Z, Chen M, Li C, Liu L and Li Y: Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753. Oncol Lett 14: 7577-7582, 2017.
APA
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., & Li, Y. (2017). Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753. Oncology Letters, 14, 7577-7582. https://doi.org/10.3892/ol.2017.7080
MLA
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., Li, Y."Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753". Oncology Letters 14.6 (2017): 7577-7582.
Chicago
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., Li, Y."Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753". Oncology Letters 14, no. 6 (2017): 7577-7582. https://doi.org/10.3892/ol.2017.7080
Copy and paste a formatted citation
x
Spandidos Publications style
Lu S, Zhang Z, Chen M, Li C, Liu L and Li Y: Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753. Oncol Lett 14: 7577-7582, 2017.
APA
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., & Li, Y. (2017). Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753. Oncology Letters, 14, 7577-7582. https://doi.org/10.3892/ol.2017.7080
MLA
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., Li, Y."Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753". Oncology Letters 14.6 (2017): 7577-7582.
Chicago
Lu, S., Zhang, Z., Chen, M., Li, C., Liu, L., Li, Y."Silibinin inhibits the migration and invasion of human gastric cancer SGC7901 cells by downregulating MMP‑2 and MMP‑9 expression via the p38MAPK signaling pathway Corrigendum in /10.3892/ol.2021.12676 Corrigendum in /10.3892/ol.2024.14753". Oncology Letters 14, no. 6 (2017): 7577-7582. https://doi.org/10.3892/ol.2017.7080
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