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Article Open Access

MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4

  • Authors:
    • Jun‑Wen Bai
    • Xia Wang
    • Ya‑Feng Zhang
    • Guo‑Dong Yao
    • Hong Liu
  • View Affiliations / Copyright

    Affiliations: The Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Department of Surgery, Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia Autonomous Region 010050, P.R. China
    Copyright: © Bai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7145-7152
    |
    Published online on: September 27, 2017
       https://doi.org/10.3892/ol.2017.7087
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Abstract

Dysregulation of microRNAs (miRs) can contribute to cancer development and progression. In the present study, the function and underlying molecular mechanisms of miR‑320 in breast cancer tumorigenesis and progression were investigated. The results of a reverse transcription‑quantitative polymerase chain reaction analysis demonstrated that miR‑320 was frequently downregulated in breast cancer tissues compared with adjacent normal tissues. In addition, knockdown of miR‑320 in breast cancer cell lines promoted cell proliferation and invasion in vitro, whereas miR‑320 overexpression had the opposite effect. Furthermore, a Dual‑Luciferase reporter assay indicated that SRY‑box 4 (SOX4) is a direct target of miR‑320, and the restoration of SOX4 in miR‑320‑overexpressing cells attenuated the tumor‑suppressive effects of miR‑320. Collectively, these results indicated that miR‑320 acts as a tumor suppressor in breast cancer tumorigenesis and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Bai JW, Wang X, Zhang YF, Yao GD and Liu H: MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4. Oncol Lett 14: 7145-7152, 2017.
APA
Bai, J., Wang, X., Zhang, Y., Yao, G., & Liu, H. (2017). MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4. Oncology Letters, 14, 7145-7152. https://doi.org/10.3892/ol.2017.7087
MLA
Bai, J., Wang, X., Zhang, Y., Yao, G., Liu, H."MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4". Oncology Letters 14.6 (2017): 7145-7152.
Chicago
Bai, J., Wang, X., Zhang, Y., Yao, G., Liu, H."MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4". Oncology Letters 14, no. 6 (2017): 7145-7152. https://doi.org/10.3892/ol.2017.7087
Copy and paste a formatted citation
x
Spandidos Publications style
Bai JW, Wang X, Zhang YF, Yao GD and Liu H: MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4. Oncol Lett 14: 7145-7152, 2017.
APA
Bai, J., Wang, X., Zhang, Y., Yao, G., & Liu, H. (2017). MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4. Oncology Letters, 14, 7145-7152. https://doi.org/10.3892/ol.2017.7087
MLA
Bai, J., Wang, X., Zhang, Y., Yao, G., Liu, H."MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4". Oncology Letters 14.6 (2017): 7145-7152.
Chicago
Bai, J., Wang, X., Zhang, Y., Yao, G., Liu, H."MicroRNA‑320 inhibits cell proliferation and invasion in breast cancer cells by targeting SOX4". Oncology Letters 14, no. 6 (2017): 7145-7152. https://doi.org/10.3892/ol.2017.7087
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