Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

UVB radiation represses CYLD expression in melanocytes

  • Authors:
    • Silke Kuphal
    • Nadja Schneider
    • Ramin Massoumi
    • Claus Hellerbrand
    • Anja Katrin Bosserhoff
  • View Affiliations / Copyright

    Affiliations: Emil‑Fischer‑Center, Institute of Biochemistry, Friedrich Alexander University Erlangen‑Nuremberg, D‑91054 Erlangen, Germany, Department of Laboratory Medicine, Translational Cancer Research, Lund University, SE‑221 00 Lund, Sweden
    Copyright: © Kuphal et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7262-7268
    |
    Published online on: October 3, 2017
       https://doi.org/10.3892/ol.2017.7120
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B‑cell lymphoma‑3/p50/p52‑dependent nuclear factor‑κB activation, which in turn triggers the expression of genes such as cyclin D1 and N‑cadherin. Elevated levels of cyclin D1 and N‑cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal‑regulated kinase‑mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB‑mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Rowe CJ and Khosrotehrani K: Clinical and biological determinants of melanoma progression: Should all be considered for clinical management? Australas J Dermatol. 57:175–181. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Qadir MI: Skin cancer: Etiology and management. Pak J Pharm Sci. 29:999–1003. 2016.PubMed/NCBI

3 

Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR and Fisher DE: Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 128:853–864. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Bastian BC: The molecular pathology of melanoma: An integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol. 9:239–271. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Premi S, Wallisch S, Mano CM, Weiner AB, Bacchiocchi A, Wakamatsu K, Bechara EJ, Halaban R, Douki T and Brash DE: Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science. 347:842–847. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Nishisgori C: Current concept of photocarcinogenesis. Photochem Photobiol Sci. 14:1713–1721. 2015. View Article : Google Scholar : PubMed/NCBI

7 

de Gruijl FR: Photocarcinogenesis: UVA vs UVB. Methods Enzymol. 319:359–366. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Tornaletti S and Pfeifer GP: UV damage and repair mechanisms in mammalian cells. Bioessays. 18:221–228. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Seebode C, Lehmann J and Emmert S: Photocarcinogenesis and Skin Cancer Prevention Strategies. Anticancer Res. 36:1371–1378. 2016.PubMed/NCBI

10 

De Fabo EC, Noonan FP, Fears T and Merlino G: Ultraviolet B but not ultraviolet A radiation initiates melanoma. Cancer Res. 64:6372–6376. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Noonan FP, Recio JA, Takayama H, Duray P, Anver MR, Rush WL, De Fabo EC and Merlino G: Neonatal sunburn and melanoma in mice. Nature. 413:271–272. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Halliday GM, Agar NS, Barnetson RS, Ananthaswamy HN and Jones AM: UV-A fingerprint mutations in human skin cancer. Photochem Photobiol. 81:3–8. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Gandini S, Sera F, Cattaruzza MS, Pasquini P, Picconi O, Boyle P and Melchi CF: Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure. Eur J Cancer. 41:45–60. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, et al: Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25:160–165. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kuphal S, Shaw-Hallgren G, Eberl M, Karrer S, Aberger F, Bosserhoff AK and Massoumi R: GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma. Oncogene. 30:4523–4530. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Massoumi R, Kuphal S, Hellerbrand C, Haas B, Wild P, Spruss T, Pfeifer A, Fässler R and Bosserhoff AK: Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma. J Exp Med. 206:221–232. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Kuphal S, Palm HG, Poser I and Bosserhoff AK: Snail-regulated genes in malignant melanoma. Melanoma Res. 15:305–313. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Ziegler-Heitbrock HW, Munker R, Johnson J, Petersmann I, Schmoeckel C and Riethmuller G: In vitro differentiation of human melanoma cells analyzed with monoclonal antibodies. Cancer Res. 45:1344–1350. 1985.PubMed/NCBI

19 

Tsuji T and Karasek M: A procedure for the isolation of primary cultures of melanocytes from newborn and adult human skin. J Invest Dermatol. 81:179–180. 1983. View Article : Google Scholar : PubMed/NCBI

20 

Spangler B, Kappelmann M, Schittek B, Meierjohann S, Vardimon L, Bosserhoff AK and Kuphal S: ETS-1/RhoC signaling regulates the transcription factor c-Jun in melanoma. Int J Cancer. 130:2801–2811. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Massoumi R, Chmielarska K, Hennecke K, Pfeifer A and Fässler R: Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell. 125:665–677. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Jobin C, Hellerbrand C, Licato LL, Brenner DA and Sartor RB: Mediation by NF-kappa B of cytokine induced expression of intercellular adhesion molecule 1 (ICAM-1) in an intestinal epithelial cell line, a process blocked by proteasome inhibitors. Gut. 42:779–787. 1998. View Article : Google Scholar : PubMed/NCBI

23 

Kuphal S, Poser I, Jobin C, Hellerbrand C and Bosserhoff AK: Loss of E-cadherin leads to upregulation of NFkappaB activity in malignant melanoma. Oncogene. 23:8509–8519. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Barberà MJ, Puig I, Domínguez D, Julien-Grille S, Guaita-Esteruelas S, Peiró S, Baulida J, Francí C, Dedhar S, Larue L, et al: Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene. 23:7345–7354. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB and Brenner DA: Inhibition of NFkappaB in activated rat hepatic stellate cells by proteasome inhibitors and an IkappaB super-repressor. Hepatology. 27:1285–1295. 1998. View Article : Google Scholar : PubMed/NCBI

26 

Schartl M, Larue L, Goda M, Bosenberg MW, Hashimoto H and Kelsh RN: What is a vertebrate pigment cell? Pigment Cell Melanoma Res. 29:8–14. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Guadarrama-Orozco JA, Ortega-Gómez A, Ruiz-García EB, Astudillo-de la Vega H, Meneses-García A and Lopez-Camarillo C: Braf V600E mutation in melanoma: Translational current scenario. Clin Transl Oncol. 18:863–871. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Brenner M, Degitz K, Besch R and Berking C: Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation. Br J Dermatol. 153:733–739. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Jhappan C, Noonan FP and Merlino G: Ultraviolet radiation and cutaneous malignant melanoma. Oncogene. 22:3099–3112. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Esparza-Soto M, Fox P and Westerhoff P: Transformation of molecular weight distributions of dissolved organic carbon and UV-absorbing compounds at full-scale wastewater-treatment plants. Water Environ Res. 78:253–262. 2006. View Article : Google Scholar : PubMed/NCBI

31 

Pak BJ, Lee J, Thai BL, Fuchs SY, Shaked Y, Ronai Z, Kerbel RS and Ben-David Y: Radiation resistance of human melanoma analysed by retroviral insertional mutagenesis reveals a possible role for dopachrome tautomerase. Oncogene. 23:30–38. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Peus D, Meves A, Vasa RA, Beyerle A, O'Brien T and Pittelkow MR: H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. Free Radic Biol Med. 27:1197–1202. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Ip YT: Transcriptional regulation. Converting an activator into a repressor. Curr Biol. 5:1–3. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Ip YT, Park RE, Kosman D, Yazdanbakhsh K and Levine M: dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev. 6:1518–1530. 1992. View Article : Google Scholar : PubMed/NCBI

35 

Marchal L, Foucaul A, Patissier G, Rosant JM and Legrand J: Influence of flow patterns on chromatographic efficiency in centrifugal partition chromatography. J Chromatogr A. 869:339–352. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kuphal S, Schneider N, Massoumi R, Hellerbrand C and Bosserhoff AK: UVB radiation represses CYLD expression in melanocytes. Oncol Lett 14: 7262-7268, 2017.
APA
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., & Bosserhoff, A.K. (2017). UVB radiation represses CYLD expression in melanocytes. Oncology Letters, 14, 7262-7268. https://doi.org/10.3892/ol.2017.7120
MLA
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., Bosserhoff, A. K."UVB radiation represses CYLD expression in melanocytes". Oncology Letters 14.6 (2017): 7262-7268.
Chicago
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., Bosserhoff, A. K."UVB radiation represses CYLD expression in melanocytes". Oncology Letters 14, no. 6 (2017): 7262-7268. https://doi.org/10.3892/ol.2017.7120
Copy and paste a formatted citation
x
Spandidos Publications style
Kuphal S, Schneider N, Massoumi R, Hellerbrand C and Bosserhoff AK: UVB radiation represses CYLD expression in melanocytes. Oncol Lett 14: 7262-7268, 2017.
APA
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., & Bosserhoff, A.K. (2017). UVB radiation represses CYLD expression in melanocytes. Oncology Letters, 14, 7262-7268. https://doi.org/10.3892/ol.2017.7120
MLA
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., Bosserhoff, A. K."UVB radiation represses CYLD expression in melanocytes". Oncology Letters 14.6 (2017): 7262-7268.
Chicago
Kuphal, S., Schneider, N., Massoumi, R., Hellerbrand, C., Bosserhoff, A. K."UVB radiation represses CYLD expression in melanocytes". Oncology Letters 14, no. 6 (2017): 7262-7268. https://doi.org/10.3892/ol.2017.7120
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team