Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

p38 predicts depression and poor outcome in esophageal cancer

  • Authors:
    • Yao Cheng
    • Zhe Qiao
    • Chengxue Dang
    • Bin Zhou
    • Shaomin Li
    • Wei Zhang
    • Jiantao Jiang
    • Yongchun Song
    • Jin Zhang
    • Dongmei Diao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710004, P.R. China, Department of Surgical Oncology, The First Affiliated Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710061, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7241-7249
    |
    Published online on: October 3, 2017
       https://doi.org/10.3892/ol.2017.7129
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

p38 mitogen‑activated protein kinase (MAPK) signaling has been implicated in the cancer development and progression. However, the precise mechanism of this association remains unknown. The aim of the present study was to evaluate the association between p38 and cancer progression, including investigations into the effects on cell proliferation, resistance to thalidomide, indoleamine 2,3‑dioxygenase (IDO) expression and prognosis in patients with esophageal cancer. The present retrospective study included patients with stage I‑III esophageal cancer. A total of 228 patients with esophageal cancer were recruited to analyze the expression of phosphorylated (p)‑p38 and IDO in tumor, and normal tissues through immunohistochemistry. Depression status was measured using the Zung Self‑Rating Depression Scale. P38 cDNA was transfected into esophageal cancer cells to assess tumor cell viability, sensitivity to thalidomide treatment and IDO gene expression. Western blotting and flow cytometry was used to analyze protein expression alterations, and apoptosis in esophageal cancer cells. P‑p38 protein was expressed in 68.9% of cancer tissues, and was significantly associated with depressive symptoms, tumor recurrence and poor survival of patients. In vitro experiments revealed that the expression of p‑p38 induced esophageal cancer Eca‑109 and TE‑1 cell viability, and resistance to thalidomide treatment, as well as in the expression of IDO without the application of lipopolysaccharides. Further follow‑up of patients revealed that depression was also an independent factor for early recurrence and overall survival rate. Altered p38 MAPK expression was associated with poor outcome in patients with esophageal cancer. p38 may be a potential biomarker for the prediction of depressive symptoms and prognosis in patients with esophageal cancer.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Rubenstein JH and Shaheen NJ: Epidemiology, diagnosis, and management of esophageal adenocarcinoma. Gastroenterology. 149:302–317. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Mortensen MB: Avoiding complications in esophageal cancer surgery. Minerva Chir. 68:341–352. 2013.PubMed/NCBI

3 

Brescia AA, Broderick SR, Crabtree TD, Puri V, Musick JF, Bell JM, Kreisel D, Krupnick AS, Patterson GA and Meyers BF: Adjuvant therapy for positive nodes after induction therapy and resection of esophageal cancer. Ann Thorac Surg. 101:200–210. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Pozza A, Erroi FR, Scarpa M, Polese L, Rampazzo L and Norberto L: Palliative therapy for esophageal cancer: Laser therapy alone is associated with a better functional outcome. Updates Surg. 67:61–67. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Wilson KG, Chochinov HM, Skirko MG, Allard P, Chary S, Gagnon PR, Macmillan K, De Luca M, O'Shea F, Kuhl D, et al: Depression and anxiety disorders in palliative cancer care. J Pain Symptom Manage. 33:118–129. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Grabsch B, Clarke DM, Love A, McKenzie DP, Snyder RD, Bloch S, Smith G and Kissane DW: Psychological morbidity and quality of life in women with advanced breast cancer: A cross-sectional survey. Palliat Support Care. 4:47–56. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Pelletier G, Verhoef MJ, Khatri N and Hagen N: Quality of life in brain tumor patients: The relative contributions of depression, fatigue, emotional distress, and existential issues. J Neurooncol. 57:41–49. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Breitbart W: Identifying patients at risk for, and treatment of major psychiatric complications of cancer. Support Care Cancer. 3:45–60. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Irving G and Lloyd-Williams M: Depression in advanced cancer. Eur J Oncol Nurs. 14:395–399. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Kadan-Lottick NS, Vanderwerker LC, Block SD, Zhang B and Prigerson HG: Psychiatric disorders and mental health service use in patients with advanced cancer: A report from the coping with cancer study. Cancer. 104:2872–2881. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Kumar B, Koul S, Petersen J, Khandrika L, Hwa JS, Meacham RB, Wilson S and Koul HK: p38 mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity. Cancer Res. 70:832–841. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Xiong S, Grijalva R, Zhang L, Nguyen NT, Pisters PW, Pollock RE and Yu D: Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration. Cancer Res. 61:1727–1732. 2001.PubMed/NCBI

13 

Kumar V, Behera R, Lohite K, Karnik S and Kundu GC: p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Cancer Res. 70:10381–10391. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Guo X, Ma N, Wang J, Song J, Bu X, Cheng Y, Sun K, Xiong H, Jiang G, Zhang B, et al: Increased p38-MAPK is responsible for chemotherapy resistance in human gastric cancer cells. BMC Cancer. 8:3752008. View Article : Google Scholar : PubMed/NCBI

15 

Coltella N, Rasola A, Nano E, Bardella C, Fassetta M, Filigheddu N, Graziani A, Comoglio PM and Di Renzo MF: p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis. Int J Cancer. 118:2981–2990. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Looby E, Abdel-Latif MM, Athié-Morales V, Duggan S, Long A and Kelleher D: Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells. BMC Cancer. 9:1902009. View Article : Google Scholar : PubMed/NCBI

17 

Yousif NG, Al-Amran FG, Hadi N, Lee J and Adrienne J: Expression of IL-32 modulates NF-κB and p38 MAP kinase pathways in human esophageal cancer. Cytokine. 61:223–227. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Zhong D, Gu C, Shi L, Xun T, Li X, Liu S and Yu L: Obatoclax induces G1/G0-phase arrest via p38/p21(waf1/Cip1) signaling pathway in human esophageal cancer cells. J Cell Biochem. 115:1624–1635. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zoga M, Oulis P, Chatzipanagiotou S, Masdrakis VG, Pliatsika P, Boufidou F, Foteli S, Soldatos CR, Nikolaou C and Papageorgiou C: Indoleamine 2,3-dioxygenase and immune changes under antidepressive treatment in major depression in females. In Vivo. 28:633–638. 2014.PubMed/NCBI

20 

Zhou W, Dantzer R, Budac DP, Walker AK, Mao-Ying QL, Lee AW, Heijnen CJ and Kavelaars A: Peripheral indoleamine 2,3-dioxygenase 1 is required for comorbid depression-like behavior but does not contribute to neuropathic pain in mice. Brain Behav Immun. 46:147–153. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Liu WL, Lin YH, Xiao H, Xing S, Chen H, Chi PD and Zhang G: Epstein-Barr virus infection induces indoleamine 2,3-dioxygenase expression in human monocyte-derived macrophages through p38/mitogen-activated protein kinase and NF-κB pathways: Impairment in T cell functions. J Virol. 88:6660–6671. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Fujigaki H, Saito K, Fujigaki S, Takemura M, Sudo K, Ishiguro H and Seishima M: The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: Involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB pathways, and synergistic effect of several proinflammatory cytokines. J Biochem. 139:655–662. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Fu X, Lawson MA, Kelley KW and Dantzer R: HIV-1 Tat activates indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures in a p38 mitogen-activated protein kinase-dependent manner. J Neuroinflammation. 8:882011. View Article : Google Scholar : PubMed/NCBI

24 

Nomura M, Shitara K, Kodaira T, Hatooka S, Mizota A, Kondoh C, Yokota T, Takahari D, Ura T and Muro K: Prognostic impact of the 6th and 7th American Joint Committee on Cancer TNM staging systems on esophageal cancer patients treated with chemoradiotherapy. Int J Radiat Oncol Biol Phys. 82:946–952. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Cheng Y, Li K, Diao D, Zhu K, Shi L, Zhang H, Yuan D, Guo Q, Wu X, Liu D and Dang C: Expression of KIAA0101 protein is associated with poor survival of esophageal cancer patients and resistance to cisplatin treatment in vitro. Lab Invest. 93:1276–1287. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Burrin JM and Price CP: Performance of three enzymic methods for filter paper glucose determination. Ann Clin Biochem. 21:411–416. 1984. View Article : Google Scholar : PubMed/NCBI

27 

Cheng Y, Diao D, Zhang H, Guo Q, Wu X, Song Y and Dang C: High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells alleviated by 2-deoxy-D-glucose. Biomed Rep. 2:188–192. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Wichers MC and Maes M: The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression. J Psychiatry Neurosci. 29:11–17. 2004.PubMed/NCBI

29 

Kohl C and Sperner-Unterweger B: IDO and clinical conditions associated with depressive symptoms. Curr Drug Metab. 8:283–287. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Zheng ST, Zhang CS, Qin X, Gen YH, Liu T, Sheyhidin I and Lu XM: The status of phosphorylated p38 in esophageal squamous cell carcinoma. Mol Biol Rep. 39:5315–5321. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Pal A, Huang W, Li X, Toy KA, Nikolovska-Coleska Z and Kleer CG: CCN6 modulates BMP signaling via the Smad-independent TAK1/p38 pathway, acting to suppress metastasis of breast cancer. Cancer Res. 72:4818–4828. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Yu JP, Sun SP, Sun ZQ, Ni XC, Wang J, Li Y, Hu LJ and Li DQ: Clinical trial of thalidomide combined with radiotherapy in patients with esophageal cancer. World J Gastroenterol. 20:5098–5103. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Sun YR, Wang XY, Li SS, Dong HY and Zhang XJ: β-asarone from Acorus gramineus alleviates depression by modulating MKP-1. Genet Mol Res. 14:4495–4504. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Cuijpers P and Cristea IA: What if a placebo effect explained all the activity of depression treatments? World Psychiatry. 14:310–311. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Qiao Z, Dang C, Zhou B, Li S, Zhang W, Jiang J, Song Y, Zhang J, Diao D, Diao D, et al: p38 predicts depression and poor outcome in esophageal cancer. Oncol Lett 14: 7241-7249, 2017.
APA
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W. ... Diao, D. (2017). p38 predicts depression and poor outcome in esophageal cancer. Oncology Letters, 14, 7241-7249. https://doi.org/10.3892/ol.2017.7129
MLA
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W., Jiang, J., Song, Y., Zhang, J., Diao, D."p38 predicts depression and poor outcome in esophageal cancer". Oncology Letters 14.6 (2017): 7241-7249.
Chicago
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W., Jiang, J., Song, Y., Zhang, J., Diao, D."p38 predicts depression and poor outcome in esophageal cancer". Oncology Letters 14, no. 6 (2017): 7241-7249. https://doi.org/10.3892/ol.2017.7129
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Qiao Z, Dang C, Zhou B, Li S, Zhang W, Jiang J, Song Y, Zhang J, Diao D, Diao D, et al: p38 predicts depression and poor outcome in esophageal cancer. Oncol Lett 14: 7241-7249, 2017.
APA
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W. ... Diao, D. (2017). p38 predicts depression and poor outcome in esophageal cancer. Oncology Letters, 14, 7241-7249. https://doi.org/10.3892/ol.2017.7129
MLA
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W., Jiang, J., Song, Y., Zhang, J., Diao, D."p38 predicts depression and poor outcome in esophageal cancer". Oncology Letters 14.6 (2017): 7241-7249.
Chicago
Cheng, Y., Qiao, Z., Dang, C., Zhou, B., Li, S., Zhang, W., Jiang, J., Song, Y., Zhang, J., Diao, D."p38 predicts depression and poor outcome in esophageal cancer". Oncology Letters 14, no. 6 (2017): 7241-7249. https://doi.org/10.3892/ol.2017.7129
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team