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Article

Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer

  • Authors:
    • Nitin Telang
  • View Affiliations / Copyright

    Affiliations: Cancer Prevention Research Program, Palindrome Liaisons Consultants, Montvale, NJ 07645‑1559, USA
  • Pages: 642-648
    |
    Published online on: October 6, 2017
       https://doi.org/10.3892/ol.2017.7147
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Abstract

Mutations in the adenomatous polyposis coli (Apc) tumor suppressor gene represent the primary genetic defect in colon carcinogenesis. Apc+/‑ mouse models exhibit pre‑invasive small intestinal adenomas. Cell culture models exhibiting Apc defects in the colon and quantifiable cancer risk provide a novel clinically relevant approach. The tumor‑derived Apc‑/‑ colonic epithelial cell line 1638N COL‑Pr1 represented the experimental model. The anti‑inflammatory drugs sulindac (SUL) and celecoxib (CLX) represented the test compounds. Compared with non‑tumorigenic Apc+/+ C57COL cells, the Apc+/‑ 1638N COL cells and Apc‑/‑ 1638N COL‑Pr1 cells exhibited progressive loss of homeostatic growth control. Compared with Apc+/‑ cells, Apc‑/‑ cells displayed increased expression of biomarkers specific for hyper‑proliferation. Treatment of Apc‑/‑ cells with SUL and CLX resulted in inhibition of anchorage‑independent colony formation in vitro, which is indicative of reduced cancer risk in vivo. Mechanistically, SUL and CLX suppressed the expression of the Apc target genes β‑catenin, cyclin D1, c‑Myc and cyclooxygenase‑2. Long‑term treatment with high concentrations of SUL and CLX led to the selection of hyper‑proliferative drug‑resistant phenotypes. The Apc‑/‑ SUL‑resistant phenotype displayed spheroid formation and enhanced the expression of the stem cell‑specific molecular markers CD44, CD133 and c‑Myc. These data demonstrated the growth‑inhibitory efficacy of SUL and CLX and indicated that drug resistance leads to the selection of a putative cancer stem cell phenotype. The study outcome validates a stem cell‑targeted mechanistic approach to identify testable alternative leads for chemotherapy-resistant colon cancer.
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View References

1 

American Cancer Society: Facts & Figures-2016. American Cancer Society; Atlanta, GA: 2016

2 

Fodde R, Smith R and Clevers H: APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer. 1:55–67. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Fodde R, Edelman W, Yang K, Van Leeuwen C, Carlson C, Renault B, Breukel C, Alt E, Lipkin M, Khan PM, et al: A targeted chain termination mutation in the mouse Apc gene results in multiple intestinal tumors. Proc Natl Acad Sci USA. 91:pp. 8969–8973. 1994; View Article : Google Scholar : PubMed/NCBI

4 

Oshima M, Oshima H, Kitagama K, Kobayashi M, Itakura C and Takata M: Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci USA. 92:pp. 4482–4486. 1995; View Article : Google Scholar : PubMed/NCBI

5 

Katdare M, Kopelovich L and Telang N: Efficacy of chemopreventive agents for growth inhibition of Apc [+/−] 1638NCOL colonic epithelial cells. Int J Mol Med. 10:427–432. 2002.PubMed/NCBI

6 

Telang NT, Li G and Katdare M: Prevention of early onset familial/hereditary colon cancer: New models and mechanistic biomarkers (review). Int J Oncol. 28:1523–1529. 2006.PubMed/NCBI

7 

Telang N and Katdare M: Combinatorial prevention of carcinogenic risk in a model for familial colon cancer. Oncol Rep. 17:909–914. 2007.PubMed/NCBI

8 

Telang N and Katdare M: Novel cell culture model for prevention of carcinogenic risk in familial polyposis syndrome. Oncol Rep. 21:1017–1021. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Telang N and Katdare M: Putative cancer initiating stem cells in a model for familial adenomatous polyposis (FAP) syndrome. Int J Mol Med. 30 Suppl 1:S102012.

10 

Telang N: Preventive efficacy of the non-steroidal anti-inflammatory drug Sulindac on cell culture models for genetically predisposed early onset colon cancer. Int J Mol Med. 34 Suppl 1:S152014.

11 

Beazer-Barkley Y, Levy DB, Moser AR, Dove WF, Hamilton SR, Vogelstein B and Kinzler KW: Sulindac suppresses tumorigenesis in the Min mouse. Carcinogenesis. 17:1757–1760. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Jacoby RF, Siebert K, Cole CE, Kelloff G and Lubet RA: The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the Min mouse model of adenomatous polyposis. Cancer Res. 60:5040–5044. 2000.PubMed/NCBI

13 

Jacoby RF, Cole CE, Tutsch F, Newton MA, Kelloff G, Hawk ET and Lubet RA: Chemopreventive efficacy of combined piroxicam and difluoromethylornithine treatment on Apc mutant Min mouse adenoma, and selective toxicity against Apc mutant embryos. Cancer Res. 60:1864–1870. 2000.PubMed/NCBI

14 

Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, McKeown-Eyssen G, Summers RW, Rothstein R, Burke CA, et al: A randomized trial for aspirin to prevent colorectal adenomas. N Engl J Med. 348:891–899. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Girdiello FM, Hamilton SR, Krush AJ, Piantadosis S, Hylind LM, Cellano P, Brooker SV, Robinson CR and Offerhans GL: Treatment of colonic and rectal adenomas with Sulindac in familial adenomatous polyposis. N Engl J Med. 328:1313–1316. 1993. View Article : Google Scholar : PubMed/NCBI

16 

Stienbeck G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, Wakabayashi N, Saunders B, Shen Y, Fujimura T, et al: The effect of Celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N Engl J Med. 342:1946–1952. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Gupta RA and Dubois RN: Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer. 1:11–21. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Solomon SD, McMurray JJ, Pfeffer MA, Wilters J, Fowler R, Finn P, Anderson WF, Zauber A, Hawk E and Bertagnolli M; Adenoma Prevention with Celecoxib (APC) Study Investigators, : Cardiovascular risk associated with Celecoxib in a clinical trial for colorectal adenoma prevention. N Engl J Med. 352:1071–1080. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Bresalier RS, Sandler RS, Quan H, Bolognese JA, Oxenius B, Horgam K, Lines C, Ridell R, Morton D, Lanas A, et al: Cardiovascular events associated with rofecocixb in a colorectal adenoma chemoprevention trial. N Engl J Med. 352:1092–1102. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Dalerba P, Dylla SJ, Park IK, Liu R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, et al: Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci USA. 104:pp. 10158–10163. 2007; View Article : Google Scholar : PubMed/NCBI

21 

O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumor growth in immunedeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Ricci-Vitiani L, Lombardi DG, Pillozi E, Biffoni M, Todaro M, Peschele C and De Maria R: Identification and expansion of human colon cancer initiating cells. Nature. 445:111–115. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Balkwill F and Mantovani A: Inflammation and cancer: Back to virchow? Lancet. 357:539–545. 2001. View Article : Google Scholar : PubMed/NCBI

24 

Tanaka T, Kohno H, Suzuki R, Hata K, Sugie S, Niho N, Sakano K, Takahashi M and Wakabayashi K: Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: Inflammatory stimuli by Dextran sodium sulfate results in development of multiple colonic neoplasms. Int J Cancer. 118:25–34. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Basudhar D, Somsudaram V, Glyn S, Ridnour LA, Cheng RY and Wink DA: Regulatory effects of NOS2-COX2 in breast progression in tumor microenvironment. Int J Mol Med. 38 Suppl l1:S812016.

26 

Katdare M, Osborne M and Telang NT: Soy isoflavone genistein modulates cell cycle progression and induces apoptosis in HER-2/neu oncogene expressing human breast epithelial cells. Int J Oncol. 21:809–815. 2002.PubMed/NCBI

27 

Boolbol SK, Dannenberg AJ, Chadburn A, Martucci C, Guo XJ, Ramonetti JT, Abreu-Goris M, Newmark HL, Lipkin ML, DeCosse JJ and Bertagnolli MM: Cyclooxygenase-2 over-expression and tumor formation are blocked by Sulindac in a murine model for familial adenomatous polyposis. Cancer Res. 56:2556–2560. 1996.PubMed/NCBI

28 

Mahmood NN, Boolbol SK, Dannenberg AJ, Mestre JR, Bilinski RT, Martucci C, Newmark HL, Chadburn A and Bertagnolli MM: The sulfide metabolite of Sulindac prevents tumors and restores enterocyte apoptosis in a murine model for familial adenomatous polyposis. Carcinogenesis. 19:87–91. 1998. View Article : Google Scholar : PubMed/NCBI

29 

Mahmood NN, Bilinski RT, Churchill MR, Edelmann W, Kucherlapati R and Bertagnolli MM: Genotype phenotype correlation in murine Apc mutation: Differences in enterocyte migration and response to sulindac. Cancer Res. 59:353–359. 1999.PubMed/NCBI

30 

Williams CS, Goldman AP, Sheng H, Morrow JD and Dubois RN: Sulindac sulfide, but not Sulindac sulfone, inhibits colorectal cancer growth. Neoplasia. 1:170–176. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Chen KL, Pan F, Jiang H, Chen JF, Pei L, Wie FW and Liang HJ: Highly enriched CD133(+)CD44(+) stem-like cells with CD133(+)CD44(high) metastatic subset in HCT116 colon cancer cells. Clin Exp Metastasis. 28:751–763. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Wang C, Xie J, Guo J, Manning HC, Gore JC and Gou N: Evaluation of CD44 and CD133 as cancer stem cell markers for colorectal cancer. Oncol Rep. 28:1301–1308. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Zhou JY, Chen M, Ma L, Wang X, Chen YG and Lui SL: Role of CD44(high)/CD133(high) HCT-116 cells in the tumorigenesis of colon cancer. Oncotarget. 7:7657–7666. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Greenspan EJ, Nichols FC and Rosenberg DW: Molecular alterations associated with Sulindac-resistant colon tumors in ApcMin/+ mice. Cancer Prev Res (Phila). 3:1187–1197. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M and Pals ST: Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis. Cancer Res. 68:3655–3661. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Hoffmeyer K, Raggioli A, Rudolf S, Anton R, Hierholzer A, Del Valle I, Hein K, Vogt R and Kemlar R: Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells. Science. 336:1549–1554. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Nasuni I, Seimiya H and Tsuruo T: Telomerase inhibition, telomere shortening, and senescence of cancer cells by tea catechins. Biochem Biophys Res Commun. 249:391–396. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Ramchandran C, Fonseca HB, Jhabvala P, Escalon EA and Melnick SJ: Curcumin inhibits telomerase activity through human telomerase reverse transcritpase in MCF-7 breast cancer cell line. Cancer Lett. 184:1–6. 2002. View Article : Google Scholar : PubMed/NCBI

39 

Jagadeesh S, Kyo S and Banerjee PP: Genestein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res. 66:2107–2115. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Arndt GM and MacKenzie KL: New prospects for targeting telomerase beyond the telomere. Nat Rev Cancer. 16:508–524. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Dean M, Fojo T and Bates S: Tumor stem cells and drug resistance. Nat Rev Cancer. 5:275–284. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Lobo NA, Shimono Y, Qian D and Clarke MF: The biology of cancer stem cells. Annu Rev Cell Dev Biol. 23:675–699. 2007. View Article : Google Scholar : PubMed/NCBI

43 

Telang N: Putative cancer initiating stem cells in cell culture models for molecular subtypes of clinical breast cancer. Oncol Lett. 10:3840–3846. 2015.PubMed/NCBI

44 

Telang N: Growth inhibitory efficacy of natural products in a model for triple negative molecular subtype of clinical breast cancer. Biomed Rep. 7:199–204. 2017.PubMed/NCBI

45 

Nguyen PH, Giraud J, Staedel C, Chambonnier L, Dubus P, Cheveret E, Boeuf H, Gauthereau X, Rousseau B, Fevre M, et al: All-trans retinoic acid targets gastric cancer stem cells and inhibits patient-derived gastric carcinoma tumor growth. Oncogene. 35:5619–5628. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Roife D, Dai B, Kang Y, Perez MVR, Pratt M, Li X and Fleming JB: Ex Vivo testing of patient-derived xenografts mirrors the clinical outcome of patients with pancreatic ductal adenocarcinoma. Clin Cancer Res. 22:6021–6030. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Crespo M, Vilar E, Tsai SY, Chang K, Amin S, Srinivasan T, Zhang T, Pipalia NH, Chen HJ, Witherspoon M, et al: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nat Med. 23:878–884. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Telang N: Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. Oncol Lett 15: 642-648, 2018.
APA
Telang, N. (2018). Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. Oncology Letters, 15, 642-648. https://doi.org/10.3892/ol.2017.7147
MLA
Telang, N."Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer". Oncology Letters 15.1 (2018): 642-648.
Chicago
Telang, N."Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer". Oncology Letters 15, no. 1 (2018): 642-648. https://doi.org/10.3892/ol.2017.7147
Copy and paste a formatted citation
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Spandidos Publications style
Telang N: Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. Oncol Lett 15: 642-648, 2018.
APA
Telang, N. (2018). Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. Oncology Letters, 15, 642-648. https://doi.org/10.3892/ol.2017.7147
MLA
Telang, N."Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer". Oncology Letters 15.1 (2018): 642-648.
Chicago
Telang, N."Anti‑inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer". Oncology Letters 15, no. 1 (2018): 642-648. https://doi.org/10.3892/ol.2017.7147
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