Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report

  • Authors:
    • Tao Wu
    • Jinmao Zhou
    • Cunbang Wang
    • Binbin Wang
    • Shuting Zhang
    • Hai Bai
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Lanzhou General Hospital, Lanzhou Command, Lanzhou, Gansu 730050, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7318-7322
    |
    Published online on: October 9, 2017
       https://doi.org/10.3892/ol.2017.7151
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Multiple myeloma (MM) is a common B‑cell hematological malignancy in the clinic. Bortezomib is the first‑in‑class proteasome inhibitor that has been approved for the treatment of patients with MM in the bone marrow. The present study report the case of an 83‑year‑old man who showed marked weakness, fatigue and a poor appetite. The patient was admitted to the Department of Nephrology due to severe renal impairment (RI). Immunofixation electrophoresis indicated a λ light chain‑positive status. There were 19.2% plasmablasts and proplasmacytes in the bone marrow. Positivity for the cell surface markers cluster of differentiation (CD)13, CD33, CD38 and human leukocyte antigen‑antigen D‑related was detected by flow cytometry. The patient was diagnosed with MM, λ light chain type, stage IIIB, and received bortezomib and dexamethasone regimen chemotherapy. RI was improved following the chemotherapy, and plasmablasts and proplasmacytes were almost eliminated. The Hb level was maintained at ~90 g/l. Overall, the present case report suggests that bortezomib may be safe and effective for elderly patients, even those >80 years of age, with severe RI.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zweegman S, Engelhardt M and Larocca A: EHA SWG on ‘Aging and Hematology’: Elderly patients with multiple myeloma: Towards a frailty approach? Curr Opin Oncol. 29:315–321. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chesi M and Bergsagel PL: Molecular pathogenesis of multiple myeloma: Basic and clinical updates. Int J Hematol. 97:313–323. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Ramsenthaler C, Kane P, Gao W, Siegert RJ, Edmonds PM, Schey SA and Higginson IJ: Prevalence of symptoms in patients with multiple myeloma: A systematic review and meta-analysis. Eur J Haematol. 97:416–429. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Dimopoulos MA and Terpos E: Renal insufficiency and failure. Hematology Am Soc Hematol Educ Program. 2010:431–436. 2010.PubMed/NCBI

5 

Knudsen LM, Hippe E, Hjorth M, Holmberg E and Westin J: Renal function in newly diagnosed multiple myeloma-a demographic study of 1353 patients. The Nordic Myeloma Study Group. Eur J Haematol. 53:207–212. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Rekhtina IG and Mendeleeva LP: Current approaches to treating of patients with multiple myeloma with renal failure: Questions and proofs. Ter Arkh. 89:112–117. 2017.(In Russian; Abstract available in Russian from the publisher). View Article : Google Scholar : PubMed/NCBI

7 

Joseph NS, Gentili S, Kaufman JL, Lonial S and Nooka AK: High-risk mutiple myiloma: Definition and management. Clin Lymphoma Myeloma Leuk. 17S:S80–S87. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Caillon H, Irimia A, Simon JS, Axel A, Sasser K, Scullion MJ, Ligneel T, Nouadje G, Moreau P and Dejoie T: Overcoming the interference of daratumumab with immunofixation electrophoresis (IFE) using an industry-developed dira test: Hydrashift 2/4 daratumumab. Blood. 128:2063. 2016.

9 

Puig N, Sarasquete ME, Balanzategui A, Martínez J, Paiva B, García H, Fumero S, Jiménez C, Alcoceba M, Chillón MC, et al: Critical evaluation of ASO RQ-PCR for minimal residual disease evaluation in multiple myeloma. A comparative analysis with flow cytometry. Leukemia. 28:391–397. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Ross FM, Avet-Loiseau H, Ameye G, Gutiérrez NC, Liebisch P, O'Connor S, Dalva K, Fabris S, Testi AM, Jarosova M, et al: Report from the european myeloma network on interphase FISH in multiple myeloma and related disorders. Haematologica. 97:1272–1277. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Abramova TV, Obukhova TN, Mendeleeva LP, Pokrovskaya OS, Gribanova EO, Ryzhko VV, Grebenyuk LA, Nareyko MV, Solovyev MV, Votyakova OM, et al: Prognostic value of 1q21 amplification in multiple myeloma. Ter Arkh. 89:32–38. 2017.(In Russian). View Article : Google Scholar : PubMed/NCBI

12 

Modesto AP, Usvyat L, Calice-Silva V, Spigolon DN, Figueiredo AE, de Moraes TP, Olandoski M, Shimakura SE, Barretti P, Kotanko P and Pecoits-Filho R: Impact of the karnofsky performance status on survival and its dynamics during the terminal year of peritoneal dialysis patients. Perit Dial Int: pii. pdi.2015.00241. 2017. View Article : Google Scholar

13 

Qian J, Jin J, Luo H, Jin C, Wang L, Qian W and Meng H: Analysis of clinical characteristics and prognostic factors of multiple myeloma: A retrospective single-center study of 787 cases. Hematology. 22:472–476. 2017.PubMed/NCBI

14 

Alexanian R, Barlogie B and Dixon D: Renal failure in multiple myeloma. Pathogenesis and prognostic implications. Arch Intern Med. 150:1693–1695. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Blade´ J, Fernández-Llama P, Bosch F, Montolíu J, Lens XM, Montoto S, Cases A, Darnell A, Rozman C and Montserrat E: Renal failure in multiple myeloma: Presenting features and predictors of outcome in 94 patients from a single institution. Arch Intern Med. 158:1889–1893. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Kyle RA, Gertz MA, Witzig TE, Lust JA, Lacy MQ, Dispenzieri A, Fonseca R, Rajkumar SV, Offord JR, Larson DR, et al: Review of 1027 patients with newlydiagnosed multiple myeloma. Mayo Clin Proc. 78:21–33. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Eleutherakis-Papaiakovou V, Bamias A, Gika D, Simeonidis A, Pouli A, Anagnostopoulos A, Michali E, Economopoulos T, Zervas K and Dimopoulos MA: Greek Myeloma Study Group: Renal failure in multiple myeloma: Incidence, correlations, and prognostic significance. Leuk Lymphoma. 48:337–341. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Torra R, Bladé J, Cases A, López-Pedret J, Montserrat E, Rozman C and Revert L: Patients with multiple myeloma requiring long-term dialysis: Presenting features, response to therapy, and outcome in a series of 20 cases. Br J Haematol. 91:854–859. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Eleftherakis-Papapiakovou E, Kastritis E, Roussou M, Gkotzamanidou M, Grapsa I, Psimenou E, Nikitas N, Terpos E and Dimopoulos MA: Renal impairment is not an independent adverse prognostic factor in patients with multiple myeloma treated upfront with novel agent-based regimens. Leuk Lymphoma. 52:2299–2303. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Dimopoulos MA, Roussou M, Gkotzamanidou M, Nikitas N, Psimenou E, Mparmparoussi D, Matsouka C, Spyropoulou-Vlachou M, Terpos E and Kastritis E: The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma. Leukemia. 27:423–429. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Chanan-Khan AA, San Miguel JF, Jagannath S, Ludwig H and Dimopoulos MA: Novel therapeutic agents for the management of patients with multiple myeloma and renal impairment. Clin Cancer Res. 18:2145–2163. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Gaballa MR, Laubach JP, Schlossman RL, Redman K, Noonan K, Mitsiades CS, Ghobrial IM, Munshi N, Anderson KC and Richardson PG: Management of myeloma-associated renal dysfunction in the era of novel therapies. Expert Rev Hematol. 5:51–66; quiz 67–68. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Costa LJ, Abbas J, Ortiz-Cruz KL, Kang Y and Stuart RK: Outcomes of patients with multiple myeloma and renal impairment treated with bortezomib, cyclophosphamide, and dexamethasone without plasma exchange. Eur J Haematol. 89:432–434. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Mulkerin D, Remick S and Takimoto C: Safety, tolerability and pharmacology of bortezomib in cancer patients with renal failure requiring dialysis: Results from a prospective phase 1 study. ASH Annu Meet Abstr. 110:34772007.

25 

Jagannath S, Barlogie B, Berenson JR, Singhal S, Alexanian R, Srkalovic G, Orlowski RZ, Richardson PG, Anderson J, Nix D, et al: Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impaired renal function. Cancer. 103:1195–1200. 2005. View Article : Google Scholar : PubMed/NCBI

26 

San-Miguel JF, Richardson PG, Sonneveld P, Schuster MW, Irwin D, Stadtmauer EA, Facon T, Harousseau JL, Ben-Yehuda D, Lonial S, et al: Efficacy and safety of bortezomib in patients with renal impairment: Results from the APEX phase 3 study. Leukemia. 22:842–849. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Chanan-Khan AA, Kaufman JL, Mehta J, Richardson PG, Miller KC, Lonial S, Munshi NC, Schlossman R, Tariman J and Singhal S: Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: A multicenter retrospective study. Blood. 109:2604–2606. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Ying WZ, Wang PX, Aaron KJ, Basnayake K and Sanders PW: Immunoglobulin light chains activate nuclear factor-κB in renal epithelial cells through a Src-dependent mechanism. Blood. 117:1301–1307. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Sarközi R, Perco P, Hochegger K, Enrich J, Wiesinger M, Pirklbauer M, Eder S, Rudnicki M, Rosenkranz AR, Mayer B, et al: Bortezomib-induced survival signals and genes in human proximal tubular cells. J Pharmacol Exp Ther. 327:645–656. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Uttamsingh V, Lu C, Miwa G and Gan LS: Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos. 33:1723–1728. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Pekol T, Daniels JS, Labutti J, Parsons I, Nix D, Baronas E, Hsieh F, Gan LS and Miwa G: Human metabolism of the proteasome inhibitor bortezomib: Identification of circulating metabolites. Drug Metab Dispos. 33:771–777. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Labutti J, Parsons I, Huang R, Miwa G, Gan LS and Daniels JS: Oxidative deboronation of the peptide boronic acid proteasome inhibitor bortezomib: Contributions from reactive oxygen species in this novel cytochrome P450 reaction. Chem Res Toxicol. 19:539–546. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Dimopoulos MA, Richardson PG, Schlag R, Khuageva NK, Shpilberg O, Kastritis E, Kropff M, Petrucci MT, Delforge M, Alexeeva J, et al: VMP (Bortezomib, Melphalan, and Prednisone) is active and well tolerated in newly diagnosed patients with multiple myeloma with moderately impaired renal function, and results in reversal of renal impairment: Cohort analysis of the phase III VISTA study. J Clin Oncol. 27:6086–6093. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Morabito F, Gentile M, Mazzone C, Rossi D, Di Raimondo F, Bringhen S, Ria R, Offidani M, Patriarca F, Nozzoli C, et al: Safety and efficacy of bortezomib-melphalan-prednisone-thalidomide followed by bortezomib-thalidomide maintenance (VMPT-VT) versus bortezomib-melphalan-prednisone (VMP) in untreated multiple myeloma patients with renal impairment. Blood. 118:5759–5766. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Ludwig H, Adam Z, Hajek R, Greil R, Tóthová E, Keil F, Autzinger EM, Thaler J, Gisslinger H, Lang A, et al: Light chain-induced acute renal failure can be reversed by bortezomib-doxorubicin-dexamethasone in multiple myeloma: Results of a phase II study. J Clin Oncol. 28:4635–4641. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Dimopoulos MA, Roussou M, Gavriatopoulou M, Zagouri F, Migkou M, Matsouka C, Barbarousi D, Christoulas D, Primenou E, Grapsa I, et al: Reversibility of renal impairment in patients with multiple myeloma treated with bortezomib-based regimens: Identification of predictive factors. Clin Lymphoma Myeloma. 9:302–306. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Batuman V, Dreisbach AW and Cyran J: Light-chain binding sites on renal brush-border membranes. Am J Physiol. 258:F1259–F1265. 1990.PubMed/NCBI

38 

Batuman V and Guan S: Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells. Am J Physiol. 272:F521–F530. 1997.PubMed/NCBI

39 

Batuman V, Verroust PJ, Navar GL, Kaysen JH, Goda FO, Campbell WC, Simon E, Pontillon F, Lyles M, Bruno J and Hammond TG: Myeloma light chains are ligands for cubilin (gp280). Am J Physiol. 275:F246–F254. 1998.PubMed/NCBI

40 

Santostefano M, Zanchelli F, Zaccaria A, Poletti G and Fusaroli M: The ultrastructural basis of renal pathology in monoclonal gammopathies. J Nephrol. 18:659–675. 2005.PubMed/NCBI

41 

Guan S, el-Dahr S, Dipp S and Batuman V: Inhibition of Na-K-ATPase activity and gene expression by a myeloma light chain in proximal tubule cells. J Investig Med. 47:496–501. 1999.PubMed/NCBI

42 

Leung N, Gertz M, Kyle RA, Fervenza FC, Irazabal MV, Eirin A, Kumar S, Cha SS, Rajkumar SV, Lacy MQ, et al: Urinary albumin excretion patterns of patients with cast nephropathy and other monoclonal gammopathy-related kidney diseases. Clin J Am Soc Nephrol. 7:1964–1968. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Mayo MM and Johns GS: Serum free light chains in the diagnosis and monitoring of patients with plasma cell dyscrasias. Contrib Nephrol. 153:44–65. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Hutchison CA, Cockwell P, Harding S, Mead GP, Bradwell AR and Barnett AH: Quantitative assessment of serum and urinary polyclonal free light chains in patients with type II diabetes: An early marker of diabetic kidney disease? Expert Opin Ther Targets. 12:667–676. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Hutchison CA, Plant T, Drayson M, Cockwell P, Kountouri M, Basnayake K, Harding S, Bradwell AR and Mead G: Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure. BMC Nephrol. 9:112008. View Article : Google Scholar : PubMed/NCBI

46 

Durie BG, Harousseau JL, Miguel JS, Bladé J, Barlogie B, Anderson K, Gertz M, Dimopoulos M, Westin J, Sonneveld P, et al: International uniform response criteria for multiple myeloma. Leukemia. 20:1467–1473. 2006. View Article : Google Scholar : PubMed/NCBI

47 

Terpos E, Katodritou E, Tsiftsakis E, et al: Cystatin-C is a sensitive marker of renal impairment with an independent predictive value for survival in multiple myeloma; reduction post bortezomib monotherapy. ASH Annu Meet Abstr. 110:14842007.

48 

Dimopoulos MA, Christoulas D, Kastritis E, et al: Tubular damage is ubiquitous in newly-diagnosed patients with multiple myeloma: Comparison of three urinary and two serum markers of kidney injury. ASH Annu Meet Abstr. 120:29192012.

49 

Gupta N, Goh YT, Min CK, Lee JH, Kim K, Wong RS, Chim CS, Hanley MJ, Yang H, Venkatakrishnan K, et al: Pharmacokinetics and safety of ixazomib plus lenalidomide-dexamethasone in Asian patients with relapsed/refractory myeloma: A phase 1 study. J Hematol Oncol. 8:1032015. View Article : Google Scholar : PubMed/NCBI

50 

Rychak E, Mendy D, Shi T, Ning Y, Leisten J, Lu L, Miller K, Narla RK, Orlowski RZ, Raymon HK, et al: Pomalidomide in combination with dexamethasone results in synergistic anti-tumour responses in pre-clinical models of lenalidomide-resistant multiple myeloma. Br J Haematol. 172:889–901. 2016. View Article : Google Scholar : PubMed/NCBI

51 

Weiss BM, Abadie J, Verma P, Howard RS and Kuehl WM: A monoclonal precedes multiple myeloma in most patients. Blood. 113:5418–5422. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Agarwal A and Ghobrial IM: Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: A review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease. Clin Cancer Res. 19:985–994. 2013. View Article : Google Scholar : PubMed/NCBI

53 

Bahlis NJ: Darwinian evolution and tiding clones in multiple myeloma. Blood. 120:927–928. 2012. View Article : Google Scholar : PubMed/NCBI

54 

Magrangeas F, Avet-Loiseau H, Gouraud W, Lodé L, Decaux O, Godmer P, Garderet L, Voillat L, Facon T, Stoppa AM, et al: Minor clone provides a reservoir for relapse in multiple myeloma. Leukemia. 27:473–481. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu T, Zhou J, Wang C, Wang B, Zhang S and Bai H: Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report. Oncol Lett 14: 7318-7322, 2017.
APA
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., & Bai, H. (2017). Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report. Oncology Letters, 14, 7318-7322. https://doi.org/10.3892/ol.2017.7151
MLA
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., Bai, H."Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report". Oncology Letters 14.6 (2017): 7318-7322.
Chicago
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., Bai, H."Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report". Oncology Letters 14, no. 6 (2017): 7318-7322. https://doi.org/10.3892/ol.2017.7151
Copy and paste a formatted citation
x
Spandidos Publications style
Wu T, Zhou J, Wang C, Wang B, Zhang S and Bai H: Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report. Oncol Lett 14: 7318-7322, 2017.
APA
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., & Bai, H. (2017). Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report. Oncology Letters, 14, 7318-7322. https://doi.org/10.3892/ol.2017.7151
MLA
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., Bai, H."Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report". Oncology Letters 14.6 (2017): 7318-7322.
Chicago
Wu, T., Zhou, J., Wang, C., Wang, B., Zhang, S., Bai, H."Bortezomib overcomes the negative prognostic impact of renal impairment in a newly diagnosed elderly patient with multiple myeloma: A case report". Oncology Letters 14, no. 6 (2017): 7318-7322. https://doi.org/10.3892/ol.2017.7151
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team