Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer

Sun,Xian‑Jun; Li,Yan‑Liang; Wang,Long‑Gang; Liu,Li‑Qing; Ma,Heng; Hou,Wen‑Hong; Yu,Jin‑Ming

doi:10.3892/ol.2017.7155

December-2017 Volume 14 Issue 6

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December-2017 Volume 14 Issue 6

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Article Open Access

Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer

Authors:
- Xian‑Jun Sun
- Yan‑Liang Li
- Long‑Gang Wang
- Li‑Qing Liu
- Heng Ma
- Wen‑Hong Hou
- Jin‑Ming Yu
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Affiliations: Department of Gastrointestinal Surgery, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China, Department of Radiotherapy, Shandong Cancer Hospital and Institute, Jinan, Shandong 250117, P.R. China, Department of Oncology, Tianjin Medical University, Tianjin 300070, P.R. China

Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 7283-7287
|
Published online on: October 10, 2017

https://doi.org/10.3892/ol.2017.7155
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Abstract

Microtubule‑associated serine/threonine kinase like (Mastl) is deregulated in a number of types of human malignancy and may be a kinase target for cancer treatment. The aim of the present study was to determine the Mastl expression in gastric cancer and to clarify its clinical and prognostic significance. Immunohistochemistry was performed on a cohort of 126 postoperative gastric cancer samples to detect the expression of Mastl and two epithelial to mesenchymal transition (EMT) markers, epithelial‑cadherin and Vimentin. The χ2 test, Kaplan‑Meier estimator analysis and Cox's regression model were used to analyze the data. Upregulated Mastl protein expression was observed in the gastric cancer tissues compared with that in the adjacent non‑cancerous gastric tissues. Increased Mastl expression was identified in 54/126 (42.9%) gastric cancer samples, and was significantly associated with lymph node metastasis, tumor relapse, EMT status and poor overall survival. Additional analysis demonstrated that the Mastl expression level stratified the patient outcome in stage III, but not stage II tumor subgroups. Cox's regression analysis revealed that increased Mastl expression was an independent prognostic factor for patients with gastric cancer. Mastl expression may be a valuable prognostic marker and a potential target for patients with gastric cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer

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