MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9

  • Authors:
    • Bo Hu
    • Jianbo Wang
    • Xunbo Jin
  • View Affiliations

  • Published online on: October 10, 2017     https://doi.org/10.3892/ol.2017.7160
  • Pages: 7583-7588
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

An accumulating number of studies have reported that the expression levels of microRNAs (miRNAs/miRs) are dysregulated in a variety of human cancer types, including renal cell carcinoma (RCC). miRNAs play essential functions in tumorigenesis and the progression of tumors by serving as oncogenes or tumor suppressors. Recently, the expression and functions of miR‑138 have been studied in a number of human cancer types; however, its role in RCC remains poorly understood. In the present study, the results revealed that miR‑138 was significantly downregulated in RCC cell lines and tissues, and that low expression levels of miR‑138 were correlated with histological grade, tumor stage and lymph node metastasis. In functional studies, restoration of miR‑138 expression inhibited cell proliferation and invasion of ACHN and A498 cells. In addition, SOX9 was validated as a direct target gene of miR‑138 in RCC. SOX9 knockdown inhibited cell proliferation and invasion of RCC, with a similar effect to that induced by miR‑138, rendering SOX9 a functional target of miR‑138 in the disease. These findings indicate that miR‑138 may present a novel target for therapeutic strategies in RCC.
View Figures
View References

Related Articles

Journal Cover

December-2017
Volume 14 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hu B, Wang J and Jin X: MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncol Lett 14: 7583-7588, 2017
APA
Hu, B., Wang, J., & Jin, X. (2017). MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncology Letters, 14, 7583-7588. https://doi.org/10.3892/ol.2017.7160
MLA
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14.6 (2017): 7583-7588.
Chicago
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14, no. 6 (2017): 7583-7588. https://doi.org/10.3892/ol.2017.7160