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Article

MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9

  • Authors:
    • Bo Hu
    • Jianbo Wang
    • Xunbo Jin
  • View Affiliations / Copyright

    Affiliations: Minimally Invasive Urology Center, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250012, P.R. China, Oncology Center, Qilu Hospital of Shandong University, Jinan, Shandong 250000, P.R. China
  • Pages: 7583-7588
    |
    Published online on: October 10, 2017
       https://doi.org/10.3892/ol.2017.7160
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Abstract

An accumulating number of studies have reported that the expression levels of microRNAs (miRNAs/miRs) are dysregulated in a variety of human cancer types, including renal cell carcinoma (RCC). miRNAs play essential functions in tumorigenesis and the progression of tumors by serving as oncogenes or tumor suppressors. Recently, the expression and functions of miR‑138 have been studied in a number of human cancer types; however, its role in RCC remains poorly understood. In the present study, the results revealed that miR‑138 was significantly downregulated in RCC cell lines and tissues, and that low expression levels of miR‑138 were correlated with histological grade, tumor stage and lymph node metastasis. In functional studies, restoration of miR‑138 expression inhibited cell proliferation and invasion of ACHN and A498 cells. In addition, SOX9 was validated as a direct target gene of miR‑138 in RCC. SOX9 knockdown inhibited cell proliferation and invasion of RCC, with a similar effect to that induced by miR‑138, rendering SOX9 a functional target of miR‑138 in the disease. These findings indicate that miR‑138 may present a novel target for therapeutic strategies in RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Hu B, Wang J and Jin X: MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncol Lett 14: 7583-7588, 2017.
APA
Hu, B., Wang, J., & Jin, X. (2017). MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncology Letters, 14, 7583-7588. https://doi.org/10.3892/ol.2017.7160
MLA
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14.6 (2017): 7583-7588.
Chicago
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14, no. 6 (2017): 7583-7588. https://doi.org/10.3892/ol.2017.7160
Copy and paste a formatted citation
x
Spandidos Publications style
Hu B, Wang J and Jin X: MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncol Lett 14: 7583-7588, 2017.
APA
Hu, B., Wang, J., & Jin, X. (2017). MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9. Oncology Letters, 14, 7583-7588. https://doi.org/10.3892/ol.2017.7160
MLA
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14.6 (2017): 7583-7588.
Chicago
Hu, B., Wang, J., Jin, X."MicroRNA‑138 suppresses cell proliferation and invasion of renal cell carcinoma by directly targeting SOX9". Oncology Letters 14, no. 6 (2017): 7583-7588. https://doi.org/10.3892/ol.2017.7160
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