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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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December-2017 Volume 14 Issue 6

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Case Report

Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report

  • Authors:
    • Libor Stanek
    • Drahomira Springer
    • Bohuslav Konopasek
    • Michal Vocka
    • Petra Tesarova
    • Martin Syrucek
    • Lubos Petruzelka
    • Ales Vicha
    • Zdenek Musil
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, First Faculty of Medicine, Charles University in Prague, 12800 Prague 2, Czech Republic, Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 12800 Prague 2, Czech Republic, Department of Oncology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 12808 Prague 2, Czech Republic, Department of Pathology, Hospital Homolka, 15030 Prague 5, Czech Republic, Department of Pediatric Haematology and Oncology, Second Faculty of Medicine, Charles University in Prague, 15006 Prague 5, Czech Republic, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, 12808 Prague 2, Czech Republic
  • Pages: 7545-7548
    |
    Published online on: October 11, 2017
       https://doi.org/10.3892/ol.2017.7167
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Abstract

Lung cancer is one of the most common malignant cancers in the Czech Republic in men, with the highest mortality rate of all the malignant diseases. The development of biological treatment enables study into novel personalized treatment options. This type of treatment is usually of high quality, and is often demanding of predictive and biopsy diagnostics, which is dependent on the quality of the collected material and close cooperation among particular departments. The present study describes the complete biopsy and predictive examinations performed in a male patient with lung adenocarcinoma, with an emphasis on the logistics of the whole process and the application of the tyrosine kinase inhibitors, crizotinib and LDK378. The patient experienced a long overall survival time of 28 months from diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Stanek L, Springer D, Konopasek B, Vocka M, Tesarova P, Syrucek M, Petruzelka L, Vicha A and Musil Z: Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report. Oncol Lett 14: 7545-7548, 2017.
APA
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M. ... Musil, Z. (2017). Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report. Oncology Letters, 14, 7545-7548. https://doi.org/10.3892/ol.2017.7167
MLA
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M., Petruzelka, L., Vicha, A., Musil, Z."Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report". Oncology Letters 14.6 (2017): 7545-7548.
Chicago
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M., Petruzelka, L., Vicha, A., Musil, Z."Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report". Oncology Letters 14, no. 6 (2017): 7545-7548. https://doi.org/10.3892/ol.2017.7167
Copy and paste a formatted citation
x
Spandidos Publications style
Stanek L, Springer D, Konopasek B, Vocka M, Tesarova P, Syrucek M, Petruzelka L, Vicha A and Musil Z: Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report. Oncol Lett 14: 7545-7548, 2017.
APA
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M. ... Musil, Z. (2017). Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report. Oncology Letters, 14, 7545-7548. https://doi.org/10.3892/ol.2017.7167
MLA
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M., Petruzelka, L., Vicha, A., Musil, Z."Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report". Oncology Letters 14.6 (2017): 7545-7548.
Chicago
Stanek, L., Springer, D., Konopasek, B., Vocka, M., Tesarova, P., Syrucek, M., Petruzelka, L., Vicha, A., Musil, Z."Molecular pathological predictive diagnostics in a patient with non‑small cell lung cancer treated with crizotinib therapy: A case report". Oncology Letters 14, no. 6 (2017): 7545-7548. https://doi.org/10.3892/ol.2017.7167
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