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Article

C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer

  • Authors:
    • Minjie Mao
    • Xiaoli Wei
    • Hui Sheng
    • Peidong Chi
    • Yijun Liu
    • Xiaoyan Huang
    • Yifan Xiang
    • Qianying Zhu
    • Shan Xing
    • Wanli Liu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Medical Oncology, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Department of Experimental Research, Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China, Zhongshan School of Medicine, Sun Yat‑sen University, Guangzhou, Guangdong 510275, P.R. China
  • Pages: 7417-7424
    |
    Published online on: October 13, 2017
       https://doi.org/10.3892/ol.2017.7179
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Abstract

Multiple studies have reported the prognostic association of certain inflammatory factors with various types of cancer. The present study assessed the prognostic value of the C‑reactive protein (CRP)/albumin (Alb) ratio and the neutrophil/lymphocyte ratio (NLR), separately and in combination, in gastric cancer (GC). A total of 337 cases pathologically diagnosed with gastric adenocarcinoma were retrospectively evaluated. The clinicopathological and prognostic relevance of the CRP/Alb ratio and NLR and their combination were analyzed. The optimal cut‑off values of the CRP/Alb ratio and NLR were 0.38 and 3.14, respectively. High CRP/Alb ratio (≥0.38) and NLR (≥3.14) values were associated with increased tumor invasion, more distant metastasis and a more advanced tumor‑node‑metastasis stage (all P<0.05). In addition, a high NLR value was also associated with increased tumor size (P=0.02). The CRP/Alb ratio (≥0.38/<0.38) and NLR (≥3.14/<3.14) were independent prognostic factors for overall survival time (OS) in GC by multivariate analysis (P=0.005 and P=0.001). Using the CRP/Alb ratio and NLR classification, patients were stratified into three subgroups with different OS time (P<0.001), which were identified as independent prognostic variables in multivariate analysis (P<0.001). The present study demonstrated that the CRP/Alb ratio and NLR were independent prognostic factors for OS in patients with GC. The combination of these indexes was associated with significant prognostic value and may further stratify prognosis.
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Copy and paste a formatted citation
Spandidos Publications style
Mao M, Wei X, Sheng H, Chi P, Liu Y, Huang X, Xiang Y, Zhu Q, Xing S, Liu W, Liu W, et al: C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncol Lett 14: 7417-7424, 2017.
APA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X. ... Liu, W. (2017). C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncology Letters, 14, 7417-7424. https://doi.org/10.3892/ol.2017.7179
MLA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14.6 (2017): 7417-7424.
Chicago
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14, no. 6 (2017): 7417-7424. https://doi.org/10.3892/ol.2017.7179
Copy and paste a formatted citation
x
Spandidos Publications style
Mao M, Wei X, Sheng H, Chi P, Liu Y, Huang X, Xiang Y, Zhu Q, Xing S, Liu W, Liu W, et al: C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncol Lett 14: 7417-7424, 2017.
APA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X. ... Liu, W. (2017). C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer. Oncology Letters, 14, 7417-7424. https://doi.org/10.3892/ol.2017.7179
MLA
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14.6 (2017): 7417-7424.
Chicago
Mao, M., Wei, X., Sheng, H., Chi, P., Liu, Y., Huang, X., Xiang, Y., Zhu, Q., Xing, S., Liu, W."C‑reactive protein/albumin and neutrophil/lymphocyte ratios and their combination predict overall survival in patients with gastric cancer". Oncology Letters 14, no. 6 (2017): 7417-7424. https://doi.org/10.3892/ol.2017.7179
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