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Article

DR2 blocker thioridazine: A promising drug for ovarian cancer therapy

Corrigendum in: /10.3892/ol.2020.11285
  • Authors:
    • Min Yong
    • Tinghe Yu
    • Si Tian
    • Shuaibin Liu
    • Jiao Xu
    • Jianguo Hu
    • Lina Hu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P.R. China, Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China, Department of Rehabilitation, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, P.R. China
  • Pages: 8171-8177
    |
    Published online on: October 16, 2017
       https://doi.org/10.3892/ol.2017.7184
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Abstract

Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel therapeutic agents in ovarian cancer, the present study aimed to determine the potential effects of thioridazine in vitro and in vivo. It was revealed that the DR2 blocker thioridazine induced cell death in a dose‑dependent manner in ovarian cancer cells. Thioridazine treatment induced apoptosis and autophagy, which may be attributed to an increased level of reactive oxygen species and associated DNA damage. Additionally, the expression of various proteins increased with oxidative stress, including nuclear factor E2‑related factor 2, which is a pivotal transcriptional factor involved in cellular responses to oxidative stress. Heme oxygenase 1, NAPDH quinone dehydrogenase 1 and hypoxia inducible factor‑1α and phosphorylated (p)‑protein kinase B expression was significantly decreased, and the expression level of p‑extracellular signal‑related kinases and p‑P38 was increased. Using 3‑methyl adenine to inhibit autophagy caused the rate of apoptosis to increase. Thioridazine inhibited the growth of SKOV3 xenografts in nude mice. The present study demonstrated that the DR2 blocker thioridazine exhibited anticancer effects in vitro and in vivo, suggesting that thioridazine may be used as a potential drug in ovarian cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Yong M, Yu T, Tian S, Liu S, Xu J, Hu J and Hu L: DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285. Oncol Lett 14: 8171-8177, 2017.
APA
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., & Hu, L. (2017). DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285. Oncology Letters, 14, 8171-8177. https://doi.org/10.3892/ol.2017.7184
MLA
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., Hu, L."DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285". Oncology Letters 14.6 (2017): 8171-8177.
Chicago
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., Hu, L."DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285". Oncology Letters 14, no. 6 (2017): 8171-8177. https://doi.org/10.3892/ol.2017.7184
Copy and paste a formatted citation
x
Spandidos Publications style
Yong M, Yu T, Tian S, Liu S, Xu J, Hu J and Hu L: DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285. Oncol Lett 14: 8171-8177, 2017.
APA
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., & Hu, L. (2017). DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285. Oncology Letters, 14, 8171-8177. https://doi.org/10.3892/ol.2017.7184
MLA
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., Hu, L."DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285". Oncology Letters 14.6 (2017): 8171-8177.
Chicago
Yong, M., Yu, T., Tian, S., Liu, S., Xu, J., Hu, J., Hu, L."DR2 blocker thioridazine: A promising drug for ovarian cancer therapy Corrigendum in /10.3892/ol.2020.11285". Oncology Letters 14, no. 6 (2017): 8171-8177. https://doi.org/10.3892/ol.2017.7184
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