Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

Nakamura,Kohei; Nakayama,Kentaro; Sanuki,Kaori; Minamoto,Toshiko; Ishibashi,Tomoka; Sato,Emi; Yamashita,Hitomi; Ishikawa,Masako; Kyo,Satoru

doi:10.3892/ol.2017.7208

December-2017 Volume 14 Issue 6

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December-2017 Volume 14 Issue 6

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Article Open Access

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

Authors:
- Kohei Nakamura
- Kentaro Nakayama
- Kaori Sanuki
- Toshiko Minamoto
- Tomoka Ishibashi
- Emi Sato
- Hitomi Yamashita
- Masako Ishikawa
- Satoru Kyo
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 6938501, Japan

Copyright: © Nakamura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 7783-7790
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Published online on: October 18, 2017

https://doi.org/10.3892/ol.2017.7208
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Abstract

This study aimed to describe the long‑term outcomes of patients with menorrhagia treated with microwave endometrial ablation (frequency, 2.45 GHz), as well as to identify factors associated with recurrence or re‑surgery. This retrospective cohort study was conducted from 2007 to 2015 at Shimane University Hospital in Japan. Patients with severe menorrhagia and a desire to preserve their uterus were included in the study. Clinical factors associated with recurrence of menorrhagia or re‑surgery were analyzed with a multivariable logistic regression model. Of 160 microwave endometrial ablation candidates, 100 had uterine myomas, 20 adenomyosis, 26 functional excessive menstruation, and 12 endometrial polyps. In the full cohort, age (<40) and uterine cavity length (≥10) were associated with recurrence of menorrhagia and re‑surgery. Among patients with myomas, age (<48) and number of myomas (≥4) were associated with recurrence, and largest myoma size (≥5) and preoperative hemoglobin level (<9 mg/dl) were associated with re‑surgery. Among subjects with adenomyosis, uterine cavity length (≥10) was associated with recurrence. Microwave endometrial ablation is thought to be a highly efficacious method to control menorrhagia caused by functional bleeding and endometrial polyps. However, microwave endometrial ablation may be less effective for patients younger than 48 years with myomas, especially those with 4 or more myomas, or with a myoma 5 cm or larger in size, and for patients with adenomyosis who have a thickened myometrium. These clinical factors may be useful predictors of success in selecting candidates for microwave endometrial ablation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Long‑term outcomes of microwave endometrial ablation for treatment of patients with menorrhagia: A retrospective cohort study

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