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Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma

  • Authors:
    • Kai Hu
    • Xiujing Xie
    • Rensheng Wang
    • Fang Wu
    • Yong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Ultrasonic Medicine, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7681-7686
    |
    Published online on: October 18, 2017
       https://doi.org/10.3892/ol.2017.7209
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Abstract

Vascular endothelial growth factor (VEGF) and its receptor, VEGFR2, serve a critical role in angiogenesis and lymphangiogenesis, which are involved in the initiation and progression of malignancies. Specific single nucleotide polymorphisms of VEGF and VEGFR2 have been shown to modulate gene expression and influence malignancy aggressiveness. The aim of the present study was to determine whether the VEGFR2 rs2071559 (T/C) polymorphism is associated with the risk of developing nasopharyngeal carcinoma (NPC) and the aggressiveness of NPC in a southern Chinese population. A case‑control study comprising 171 NPC patients and 184 healthy individuals was performed. Genotyping of the rs2071559 polymorphism was performed by quantitative polymerase chain reaction using TaqMan probes. Genotype and allele distribution of the rs2071559 polymorphism was not associated with the risk of NPC following adjustment for age, sex and ethnicity by multivariate logistic regression analyses. Regional lymph node metastasis was significantly correlated with the rs2071559 C allele and the related genotypes (OR 0.402, 95% CI 0.193‑0.835, P=0.016; and OR 0.347, 95% CI 0.145‑0.829, P=0.024, respectively). No correlations between genotype or allele distribution and the primary tumor size, distant metastasis, clinical stage, or histological type were observed. The rs2071559 polymorphism was shown to have an association with lymphatic metastasis in patients with NPC; however, the precise molecular mechanism should be elucidated in additional studies.
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Copy and paste a formatted citation
Spandidos Publications style
Hu K, Xie X, Wang R, Wu F and Zhang Y: Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma. Oncol Lett 14: 7681-7686, 2017.
APA
Hu, K., Xie, X., Wang, R., Wu, F., & Zhang, Y. (2017). Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma. Oncology Letters, 14, 7681-7686. https://doi.org/10.3892/ol.2017.7209
MLA
Hu, K., Xie, X., Wang, R., Wu, F., Zhang, Y."Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma". Oncology Letters 14.6 (2017): 7681-7686.
Chicago
Hu, K., Xie, X., Wang, R., Wu, F., Zhang, Y."Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma". Oncology Letters 14, no. 6 (2017): 7681-7686. https://doi.org/10.3892/ol.2017.7209
Copy and paste a formatted citation
x
Spandidos Publications style
Hu K, Xie X, Wang R, Wu F and Zhang Y: Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma. Oncol Lett 14: 7681-7686, 2017.
APA
Hu, K., Xie, X., Wang, R., Wu, F., & Zhang, Y. (2017). Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma. Oncology Letters, 14, 7681-7686. https://doi.org/10.3892/ol.2017.7209
MLA
Hu, K., Xie, X., Wang, R., Wu, F., Zhang, Y."Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma". Oncology Letters 14.6 (2017): 7681-7686.
Chicago
Hu, K., Xie, X., Wang, R., Wu, F., Zhang, Y."Association of the rs2071559 (T/C) polymorphism with lymphatic metastasis in patients with nasopharyngeal carcinoma". Oncology Letters 14, no. 6 (2017): 7681-7686. https://doi.org/10.3892/ol.2017.7209
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