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Case Report Open Access

Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report

  • Authors:
    • Mengyao Wu
    • Xiaoqiu Li
    • Feng Tang
    • Ping Zhu
    • Tianling Ding
    • Yan Yuan
    • Tong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai 200032, P.R. China, Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7723-7732
    |
    Published online on: October 18, 2017
       https://doi.org/10.3892/ol.2017.7212
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Abstract

Bilineage T lymphoid and myeloid (T/My) neoplasms are rare entities among the hematopoietic and lymphoid malignancies. The majority of patients present with leukemic symptoms in which blasts are observed in the peripheral blood (PB) or bone marrow (BM) at a percentage of >20% of nucleated cells. Only a minimal number of cases of T/My bilineage hematopoietic and lymphoid malignancy have been reported with extramedullary infiltration as the initial symptom. The origin of the neoplastic cells in T/My bilineage malignancy has been documented as the hematopoietic stem cells. The present study reports the case of a 31‑year‑old man with a T/My bilineage malignancy, which initially showed cervical lymph node enlargement beyond the diagnostic criteria of leukemia in the PB and in the BM. Two distinct malignant populations were detected in the cervical lymph node and pleural effusion, one of which was positive for MPO‑staining, while the other was positive for cytoplasmic cluster of differentiation 3. Mutations in platelet‑derived growth factor receptor α, platelet‑derived growth factor receptor β, fibroblast growth factor receptor 1 and other chromosome abnormalities were excluded. The patient obtained complete remission after conventional chemotherapy, but relapsed with bilineage leukemia within a short period of time. Lymphoid and myeloid lineages have been reported to be differentiated from multipotent progenitors asymmetrically. However, the cellular mutation stage in T/My bilineage malignancy remains unclear. The present study also reviews the origin, development and therapeutic strategies for extramedullary T/My bilineage malignancy.
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View References

1 

Weinberg OK and Arber DA: Mixed-phenotype acute leukemia: Historical overview and a new definition. Leukemia. 24:1844–1851. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J and Vardiman JW: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 4th edition. IARC; Lyon: pp. 150–155. 2008

3 

Béné MC and Porwit A: Acute leukemias of ambiguous lineage. Semin Diagn Pathol. 29:12–18. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Béné MC: Biphenotypic, bilineal, ambiguous or mixed lineage: Strange leukemias! Haematologica. 94:891–893. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Nishiuchi T, Ohnishi H, Kamada R, Kikuchi F, Shintani T, Waki F, Kitanaka A, Kubota Y, Tanaka T and Ishida T: Acute leukemia of ambiguous lineage, biphenotype, without CD34, TdT or TCR-rearrangement. Intern Med. 48:1437–1441. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Tota G, Coccaro N, Zagaria A, Anelli L, Casieri P, Cellamare A, Minervini A, Minervini CF, Brunetti C, Impera L, et al: ADAMTS2 gene dysregulation in T/myeloid mixed phenotype acute leukemia. BMC Cancer. 14:9632014. View Article : Google Scholar : PubMed/NCBI

7 

Bachir F, Zerrouk J, Howard SC, Graoui O, Lahjouji A, Hessissen L, Bennani S, Quessar A and El Aouad R: Outcomes in patients with mixed phenotype acute leukemia in Morocco. J Pediatr Hematol Oncol. 36:e392–e397. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Sharma P, Lall M, Jain P, Saraf A, Sachdeva A and Bhargava M: A Bi-Lineal acute leukemia (T/Myeloid, NOS) with complex cytogenetic abnormalities. Indian J Hematol Blood Transfus. 29:119–122. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Colovic M, Colovic N, Jankovic G, Kurtovic Kraguljac N, Vidovic A, Djordjevic V and Bogdanovic A: Mixed phenotype acute leukemia of T/myeloid type with a prominent cellular heterogeneity and unique karyotypic aberration 45,XY, dic(11;17). Int J Lab Hematol. 34:290–294. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Oliveira JL, Kumar R, Khan SP, Law ME, Erickson-Johnson M, Oliveira AM, Ketterling RP and Dogan A: Successful treatment of a child with T/myeloid acute bilineal leukemia associated with TLX3/BCL11B fusion and 9q deletion. Pediatr Blood Cancer. 56:467–469. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Weir EG, Ali Ansari-Lari M, Batista DA, Griffin CA, Fuller S, Smith BD and Borowitz MJ: Acute bilineal leukemia: A rare disease with poor outcome. Leukemia. 21:2264–2270. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Kobayashi N, Matsuda K, Sakashita K, Matsuzaki S, Iwasaki R and Koike K: Bilineage acute leukemia of T-lymphoid and myeloid lineages. Haematologica. 89:1139–1141. 2004.PubMed/NCBI

13 

Akashi K, Shibuya T, Harada M, Morioka E, Oshima K, Kimura N, Takeshita M, Kurokawa M, Kikuchi M and Niho Y: Acute ‘bilineal-biphenotypic’ leukaemia. Br J Haematol. 74:402–407. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Akashi K, Harada M, Shibuya T, Morioka E, Okamura T, Asano Y, Taniguchi S, Teshima T, Kikuchi M and Niho Y: Clinical characteristics of hybrid leukemia: Report of five cases. Leuk Res. 14:145–153. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Licci S, Canal F, Tos Dei AP, Fedrigo M, Gherlinzoni F, Brenna A, Zanatta L and Rossi S: Aleukemic granulocytic sarcoma with associated T-cell lymphoblastic lymphoma in the same lymph node: Morphologic features and molecular signatures. Leuk Lymphoma. 49:1411–1415. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Schwarz J, Trnková Z, Bedrlíková R, Jirásek A, Záková D, Trnený M, Sedlácková E, Kodetová D, Valenta J, Stöckbauer P, et al: Aleukemic granulocytic sarcoma with AML1/ETO fusion gene expression and clonal T cell populations. Leuk Res. 25:1137–1142. 2001. View Article : Google Scholar : PubMed/NCBI

17 

van Dongen JJ, Langerak AW, Brüggemann M, Evans PA, Hummel M, Lavender FL, Delabesse E, Davi F, Schuuring E, García-Sanz R, et al: Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: Report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 17:2257–2317. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Patnaik MM, Gangat N, Knudson RA, Keefe JG, Hanson CA, Pardanani A, Ketterling RP and Tefferi A: Chromosome 8p11.2 translocations: Prevalence, FISH analysis for FGFR1 and MYST3, and clinicopathologic correlates in a consecutive cohort of 13 cases from a single institution. Am J Hematol. 85:238–242. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Lai AY and Kondo M: T and B lymphocyte differentiation from hematopoietic stem cell. Semin Immunol. 20:207–212. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Lai AY, Lin SM and Kondo M: Heterogeneity of Flt3-expressing multipotent progenitors in mouse bone marrow. J Immunol. 175:5016–5023. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Lai AY and Kondo M: Asymmetrical lymphoid and myeloid lineage commitment in multipotent hematopoietic progenitors. J Exp Med. 203:1867–1873. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Adolfsson J, Månsson R, Buza-Vidas N, Hultquist A, Liuba K, Jensen CT, Bryder D, Yang L, Borge OJ, Thoren LA, et al: Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell. 121:295–306. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Koch U and Radtke F: Mechanisms of T cell development and transformation. Annu Rev Cell Dev Biol. 27:539–562. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Ceredig R and Rolink T: A positive look at double-negative thymocytes. Nat Rev Immunol. 2:888–897. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Kawamoto H, Ikawa T, Masuda K, Wada H and Katsura Y: A map for lineage restriction of progenitors during hematopoiesis: The essence of the myeloid-based model. Immunol Rev. 238:23–36. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Nagano M, Kimura N, Akiyoshi T, Nishimura J, Kozuru M, Okamura J, Katsuno M, Yoshida T, Takeshita M, Tachibana K, et al: T-stem cell leukemia/lymphoma with both myeloid lineage conversion and T-specific delta recombination. Leuk Res. 21:763–773. 1997. View Article : Google Scholar : PubMed/NCBI

27 

Katsuno M, Abe Y, Taguchi F, Yufu Y, Sadamura S, Goto T, Takatsuki H, Nishimura J, Hirata J, Akiyoshi T, et al: CD7+ stem cell leukemia/lymphoma. Features of a subgroup without circulating blast cells. Cancer. 72:99–104. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Silva ML, de Oliveira MS, Valente AN, Abdelhay E, Bouzas LF, Laun L and Ribeiro RC: CD7+, CD4-/CD8- acute leukemia with t(11;14)(p15;q11) in a child. Cancer Genet Cytogenet. 56:171–176. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Kurtzberg J, Waldmann TA, Davey MP, Bigner SH, Moore JO, Hershfield MS and Haynes BF: CD7+, CD4-, CD8- acute leukemia: A syndrome of malignant pluripotent lymphohematopoietic cells. Blood. 73:381–390. 1989.PubMed/NCBI

30 

Hershfield MS, Kurtzberg J, Harden E, Moore JO, Whang-Peng J and Haynes BF: Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2′-deoxycoformycin. Proc Natl Acad Sci USA. 81:pp. 253–257. 1984, View Article : Google Scholar : PubMed/NCBI

31 

Onciu M: Acute lymphoblastic leukemia. Hematol Oncol Clin North Am. 23:655–674. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, et al: The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature. 481:157–163. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Bell JJ and Bhandoola A: The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature. 452:764–767. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Wada H, Masuda K, Satoh R, Kakugawa K, Ikawa T, Katsura Y and Kawamoto H: Adult T-cell progenitors retain myeloid potential. Nature. 452:768–772. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Rothenberg EV, Moore JE and Yui MA: Launching the T-cell-lineage developmental programme. Nat Rev Immunol. 8:9–21. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Coustan-Smith E, Mullighan CG, Onciu M, Behm FG, Raimondi SC, Pei D, Cheng C, Su X, Rubnitz JE, Basso G, et al: Early T-cell precursor leukaemia: A subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol. 10:147–156. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Shimizu H, Saitoh T, Machida S, Kako S, Doki N, Mori T, Sakura T, Kanda Y, Kanamori H, Miyawaki S, et al: Allogeneic hematopoietic stem cell transplantation for adult patients with mixed phenotype acute leukemia: Results of a matched-pair analysis. Eur J Haematol. 95:455–460. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu M, Li X, Tang F, Zhu P, Ding T, Yuan Y and Chen T: Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report. Oncol Lett 14: 7723-7732, 2017.
APA
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., & Chen, T. (2017). Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report. Oncology Letters, 14, 7723-7732. https://doi.org/10.3892/ol.2017.7212
MLA
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., Chen, T."Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report". Oncology Letters 14.6 (2017): 7723-7732.
Chicago
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., Chen, T."Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report". Oncology Letters 14, no. 6 (2017): 7723-7732. https://doi.org/10.3892/ol.2017.7212
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Li X, Tang F, Zhu P, Ding T, Yuan Y and Chen T: Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report. Oncol Lett 14: 7723-7732, 2017.
APA
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., & Chen, T. (2017). Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report. Oncology Letters, 14, 7723-7732. https://doi.org/10.3892/ol.2017.7212
MLA
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., Chen, T."Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report". Oncology Letters 14.6 (2017): 7723-7732.
Chicago
Wu, M., Li, X., Tang, F., Zhu, P., Ding, T., Yuan, Y., Chen, T."Aleukemic extramedullary T lymphoid/myeloid bilineage hematopoietic and lymphoid malignancy with progression to bilineage leukemia at relapse: A case report". Oncology Letters 14, no. 6 (2017): 7723-7732. https://doi.org/10.3892/ol.2017.7212
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