Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2017 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma

  • Authors:
    • Yong Cheng
    • Qingyu Meng
    • Lvzhen Huang
    • Xuan Shi
    • Jing Hou
    • Xiaoxin Li
    • Jianhong Liang
  • View Affiliations / Copyright

    Affiliations: Ophthalmology Department, Peking University People's Hospital, Beijing 100044, P.R. China
  • Pages: 8084-8091
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/ol.2017.7221
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to analyze proteins in the aqueous humor (AH) of patients' retinoblastoma (RB), and investigate their potential role in RB using the comparative proteomic technique of isobaric tags for relative and absolute quantitation (iTRAQ) coupled with offline two‑dimensional liquid chromatography‑tandem mass spectrometry. A total of 0.1 ml AH was collected from 10 children with RB (mean age, 3.8 years; range, 2‑5 years) and patients with senile cataracts (mean age, 70.4 years; range, 65‑79 years), which was used as the control. iTRAQ was used to analyze proteins in the AH of patients and controls. Proteins with a fold change of >1.20 or <0.83 were considered to be significantly differentially expressed (with corrected P<0.05). The identified proteins were subjected to subsequent gene ontology (GO) analysis using the DAVID database. A total of 83 proteins that were expressed differently between the controls and patients' AH samples were identified using iTRAQ analysis. Of these proteins, 44 were upregulated and 39 were downregulated. On the basis of biological processes in GO, the identified proteins were primarily involved in glycoprotein, amyloid acute‑inflammatory and defensive responses. Among these proteins, pigment epithelium‑derived factor serves a potential role in the treatment of RB, and stimulated by retinoic acid 6 may serve as a potential protein involved in RB development. To the best of our knowledge, the present study is the first to identify 83 proteins associated with RB using iTRAQ technology. The results of the present study will aid in furthering the understanding of RB and developing novel therapy targets in the future.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Bishop JO and Madson EC: Retinoblastoma. Review of the current status. Surv Ophthalmol. 19:342–366. 1975.PubMed/NCBI

2 

Knudson AG: Cancer genetics. Am J Med Genet. 111:96–102. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Corson TW and Gallie BL: One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer. 46:617–634. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Vandhana S, Lakshmi TS, Indra D, Deepa PR and Krishnakumar S: Microarray analysis and biochemical correlations of oxidative stress responsive genes in retinoblastoma. Curr Eye Res. 37:830–841. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Tannu NS and Hemby SE: Methods for proteomics in neuroscience. Prog Brain Res. 158:41–82. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Shields CL, Mashayekhi A, Au AK, Czyz C, Leahey A, Meadows AT and Shields JA: The International Classification of Retinoblastoma predicts chemoreduction success. Ophthalmology. 113:2276–2280. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Munier FL, Soliman S, Moulin AP, Gaillard MC, Balmer A and Beck-Popovic M: Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track. Br J Ophthalmol. 96:1084–1087. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Duan X, Lu Q, Xue P, Zhang H, Dong Z, Yang F and Wang N: Proteomic analysis of aqueous humor from patients with myopia. Mol Vis. 14:370–377. 2008.PubMed/NCBI

9 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Steele FR, Chader GJ, Johnson LV and Tombran-Tink J: Pigment epithelium-derived factor: Neurotrophic activity and identification as a member of the serine protease inhibitor gene family. Proc Natl Acad Sci USA. 90:pp. 1526–1530. 1993, View Article : Google Scholar : PubMed/NCBI

11 

Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W and Bouck NP: Pigment epithelium-derived factor: A potent inhibitor of angiogenesis. Science. 285:245–248. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Subramanian P, Deshpande M, Locatelli-Hoops S, Moghaddam-Taaheri S, Gutierrez D, Fitzgerald DP, Guerrier S, Rapp M, Notario V and Becerra SP: Identification of pigment epithelium-derived factor protein forms with distinct activities on tumor cell lines. J Biomed Biotechnol. 2012:4259072012. View Article : Google Scholar : PubMed/NCBI

13 

Guan M, Jiang H, Xu C, Xu R, Chen Z and Lu Y: Adenovirus-mediated PEDF expression inhibits prostate cancer cell growth and results in augmented expression of PAI-2. Cancer Biol Ther. 6:419–425. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Guan M, Pang CP, Yam HF, Cheung KF, Liu WW and Lu Y: Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor. Cancer Gene Ther. 11:325–332. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Orgaz JL, Ladhani O, Hoek KS, Fernández-Barral A, Mihic D, Aguilera O, Seftor EA, Bernad A, Rodríguez-Peralto JL, Hendrix MJ, et al: ‘Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma’. Oncogene. 28:4147–4161. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Li L, Yao YC, Fang SH, Ma CQ, Cen Y, Xu ZM, Dai ZY, Li C, Li S, Zhang T, et al: Pigment epithelial-derived factor (PEDF)-triggered lung cancer cell apoptosis relies on p53 protein-driven Fas ligand (Fas-L) up-regulation and Fas protein cell surface translocation. J Biol Chem. 289:30785–30799. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Bouck N: PEDF: Anti-angiogenic guardian of ocular function. Trends Mol Med. 8:330–334. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Mori K, Duh E, Gehlbach P, Ando A, Takahashi K, Pearlman J, Mori K, Yang HS, Zack DJ, Ettyreddy D, et al: Pigment epithelium-derived factor inhibits retinal and choroidal neovascularization. J Cell Physiol. 188:253–263. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Amaral J and Becerra SP: Effects of human recombinant PEDF protein and PEDF-derived peptide 34-mer on choroidal neovascularization. Invest Ophthalmol Vis Sci. 51:1318–1326. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yang H, Cheng R, Liu G, Zhong Q, Li C, Cai W, Yang Z, Ma J, Yang X and Gao G: PEDF inhibits growth of retinoblastoma by anti-angiogenic activity. Cancer Sci. 100:2419–2425. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Chazaud C, Bouillet P, Oulad-Abdelghani M and Dollé P: Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification. Dev Genet. 19:66–73. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Kawaguchi R, Yu J, Honda J, Hu J, Whitelegge J, Ping P, Wiita P, Bok D and Sun H: A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A. Science. 315:820–825. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Berry DC, Levi L and Noy N: Holo-retinol-binding protein and its receptor STRA6 drive oncogenic transformation. Cancer Res. 74:6341–6351. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Szeto W, Jiang W, Tice DA, Rubinfeld B, Hollingshead PG, Fong SE, Dugger DL, Pham T, Yansura DG, Wong TA, et al: Overexpression of the retinoic acid-responsive gene Stra6 in human cancers and its synergistic induction by Wnt-1 and retinoic acid. Cancer Res. 61:4197–4205. 2001.PubMed/NCBI

25 

Carrera S, Cuadrado-Castano S, Samuel J, Jones GD, Villar E, Lee SW and Macip S: Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 20:910–919. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Dube DH and Bertozzi CR: Glycans in cancer and inflammation-potential for therapeutics and diagnostics. Nat Rev Drug Discov. 4:477–488. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Bertozzi CR and Kiessling LL: Chemical glycobiology. Science. 291:2357–2364. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Chen S, LaRoche T, Hamelinck D, Bergsma D, Brenner D, Simeone D, Brand RE and Haab BB: Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays. Nat Methods. 4:437–444. 2007.PubMed/NCBI

29 

Taniguchi N and Kizuka Y: Glycans and cancer: Role of N-glycans in cancer biomarker, progression and metastasis, and therapeutics. Adv Cancer Res. 126:11–51. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Pinho SS and Reis CA: Glycosylation in cancer: Mechanisms and clinical implications. Nat Rev Cancer. 15:540–555. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Compagno D, Gentilini LD, Jaworski FM, Pérez IG, Contrufo G and Laderach DJ: Glycans and galectins in prostate cancer biology, angiogenesis and metastasis. Glycobiology. 24:899–906. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Kreunin P, Zhao J, Rosser C, Urquidi V, Lubman DM and Goodison S: Bladder cancer associated glycoprotein signatures revealed by urinary proteomic profiling. J Proteome Res. 6:2631–2639. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Tian M, Cui YZ, Song GH, Zong MJ, Zhou XY, Chen Y and Han JX: Proteomic analysis identifies MMP-9, DJ-1 and A1BG as overexpressed proteins in pancreatic juice from pancreatic ductal adenocarcinoma patients. BMC cancer. 8:2412008. View Article : Google Scholar : PubMed/NCBI

34 

Libreros S and Iragavarapu-Charyulu V: YKL-40/CHI3L1 drives inflammation on the road of tumor progression. J Leukoc Biol. 98:931–936. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Wang XW, Cai CL, Xu JM, Jin H and Xu ZY: Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis. Tumour Biol. 36:901–907. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Kushner I: Regulation of the acute phase response by cytokines. Perspect Biol Med. 36:611–622. 1993. View Article : Google Scholar : PubMed/NCBI

37 

Davalieva K, Kiprijanovska S, Komina S, Petrusevska G, Zografska NC and Polenakovic M: Proteomics analysis of urine reveals acute phase response proteins as candidate diagnostic biomarkers for prostate cancer. Proteome Sci. 13:22015. View Article : Google Scholar : PubMed/NCBI

38 

Hoenerhoff MJ: Inflammation and cancer: Partners in crime. Vet J. 206:1–2. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Raposo TP, Beirão BC, Pang LY, Queiroga FL and Argyle DJ: Inflammation and cancer: Till death tears them apart. Vet J. 205:161–174. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Gerner C, Steinkellner W, Holzmann K, Gsur A, Grimm R, Ensinger C, Obrist P and Sauermann G: Elevated plasma levels of crosslinked fibrinogen gamma-chain dimer indicate cancer-related fibrin deposition and fibrinolysis. Thromb Haemost. 85:494–501. 2001.PubMed/NCBI

41 

Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M and Degen JL: Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood. 105:178–185. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Bloomston M, Zhou JX, Rosemurgy AS, Frankel W, Muro-Cacho CA and Yeatman TJ: Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples. Cancer Res. 66:2592–2599. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Yang J, Xiong X, Wang X, Guo B, He K and Huang C: Identification of peptide regions of SERPINA1 and ENOSF1 and their protein expression as potential serum biomarkers for gastric cancer. Tumour Biol. 36:5109–5118. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Kwon CH, Park HJ, Choi JH, Lee JR, Kim HK, Jo HJ, Kim HS, Oh N, Song GA and Park DY: Snail and serpinA1 promote tumor progression and predict prognosis in colorectal cancer. Oncotarget. 6:20312–20326. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Kwon CH, Park HJ, Lee JR, Kim HK, Jeon TY, Jo HJ, Kim DH, Kim GH and Park DY: Serpin peptidase inhibitor clade A member 1 is a biomarker of poor prognosis in gastric cancer. Br J Cancer. 111:1993–2002. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Zhang X, Xiao Z, Liu X, Du L, Wang L, Wang S, Zheng N, Zheng G, Li W, Zhang X, et al: The potential role of ORM2 in the development of colorectal cancer. PLoS One. 7:e318682012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Meng Q, Huang L, Shi X, Hou J, Li X and Liang J: iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma. Oncol Lett 14: 8084-8091, 2017.
APA
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., & Liang, J. (2017). iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma. Oncology Letters, 14, 8084-8091. https://doi.org/10.3892/ol.2017.7221
MLA
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., Liang, J."iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma". Oncology Letters 14.6 (2017): 8084-8091.
Chicago
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., Liang, J."iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma". Oncology Letters 14, no. 6 (2017): 8084-8091. https://doi.org/10.3892/ol.2017.7221
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Meng Q, Huang L, Shi X, Hou J, Li X and Liang J: iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma. Oncol Lett 14: 8084-8091, 2017.
APA
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., & Liang, J. (2017). iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma. Oncology Letters, 14, 8084-8091. https://doi.org/10.3892/ol.2017.7221
MLA
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., Liang, J."iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma". Oncology Letters 14.6 (2017): 8084-8091.
Chicago
Cheng, Y., Meng, Q., Huang, L., Shi, X., Hou, J., Li, X., Liang, J."iTRAQ‑based quantitative proteomic analysis and bioinformatics study of proteins in retinoblastoma". Oncology Letters 14, no. 6 (2017): 8084-8091. https://doi.org/10.3892/ol.2017.7221
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team