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Article Open Access

Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer

  • Authors:
    • Gaixia Lu
    • Da Fu
    • Chengyou Jia
    • Li Chai
    • Yang Han
    • Jin Liu
    • Tingmiao Wu
    • Ruting Xie
    • Zhengyan Chang
    • Huiqiong Yang
    • Pei Luo
    • Zhongwei Lv
    • Fei Yu
    • Xiaojun Zhong
    • Yushui Ma
  • View Affiliations / Copyright

    Affiliations: Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Radiology, Translational Medicine Center and Medical Imaging Research Institute, Central Hospital of Baotou, Inner Mongolia Medical University, Baotou, Inner Mongolia Autonomous Region 014040, P.R. China, Department of Pathology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China, Department of Medical Oncology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7842-7848
    |
    Published online on: October 19, 2017
       https://doi.org/10.3892/ol.2017.7228
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Abstract

Altered expression of microRNAs (miRNAs or miRs) contributes to lung carcinogenesis. The present study performed an in silico analysis of differentially expressed miRNAs in different peripheral blood samples from patients with various diseases vs. controls using the Gene Expression Omnibus (GEO) database data, and assessed miR‑105‑1 expression in 32 normal lung and 142 non‑small cell lung cancer (NSCLC) tissue samples using reverse transcription‑quantitative polymerase chain reaction. Survival data were calculated using Kaplan‑Meier curves and a log‑rank test. The stepwise forward Cox regression model was performed for univariate and multivariate analyses of independent predictor of overall survival (OS) of patients. The data on in silico and tissue microarray analyses of miRNA expression revealed reduced miR‑105‑1 expression in different types of human cancer, particularly in NSCLC. The level of miR‑105‑1 expression was confirmed to be downregulated in NSCLC tissues compared with that in normal lung tissues. Reduced miR‑105‑1 expression was associated with larger tumor size as well as poor OS and disease‑free survival (DFS) of patients. Multivariate survival analysis demonstrated that reduced miR‑105‑1 expression and tumor size were independent predictors for OS of NSCLC patients. In conclusion, reduced miR‑105‑1 expression in NSCLC tissues is associated with poor OS and DFS of NSCLC patients.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Hill A, Fisher P and Yeomanson D: Non-small cell lung cancer. BMJ. 345:e64432012. View Article : Google Scholar : PubMed/NCBI

4 

Cykert S, Dilworth-Anderson P, Monroe MH, Walker P, McGuire FR, Corbie-Smith G, Edwards LJ and Bunton AJ: Factors associated with decisions to undergo surgery among patients with newly diagnosed early-stage lung cancer. JAMA. 303:2368–2376. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fervers B: Chemotherapy in elderly patients with resected stage II–IIIA lung cancer. BMJ. 343:d41042011. View Article : Google Scholar : PubMed/NCBI

6 

Sullivan R, Alatise OI, Anderson BO, Audisio R, Autier P, Aggarwal A, Balch C, Brennan MF, Dare A, D'Cruz A, et al: Global cancer surgery: Delivering safe, affordable, and timely cancer surgery. Lancet Oncol. 16:1193–1224. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Global Burden of Disease Cancer Collaboration, Fitzmaurice C, . Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et al: The Global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

8 

National Lung Screening Trial Research Team, . Church TR, Black WC, Aberle DR, Berg CD, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gierada DS, et al: Results of initial low-dose computed tomographic screening for lung cancer. N Engl J Med. 368:1980–1991. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Gasparini P, Cascione L, Landi L, Carasi S, Lovat F, Tibaldi C, Alì G, D'Incecco A, Minuti G, Chella A, et al: microRNA classifiers are powerful diagnostic/prognostic tools in ALK-, EGFR-, and KRAS-driven lung cancers. Proc Natl Acad Sci USA. 112:pp. 14924–14929. 2015, View Article : Google Scholar : PubMed/NCBI

10 

Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, et al: MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 518:107–110. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Martello G, Rosato A, Ferrari F, Manfrin A, Cordenonsi M, Dupont S, Enzo E, Guzzardo V, Rondina M, Spruce T, et al: A MicroRNA targeting dicer for metastasis control. Cell. 141:1195–1207. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Peinado H, Alečković M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, García-Santos G, Ghajar C, et al: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 18:883–891. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Zhou W, Fong MY, Min Y, Somlo G, Liu L, Palomares MR, Yu Y, Chow A, O'Connor ST, Chin AR, et al: Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis. Cancer Cell. 25:501–515. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hood JL, San RS and Wickline SA: Exosomes released by melanoma cells prepare sentinel lymph nodes for tumor metastasis. Cancer Res. 71:3792–3801. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Guan Y, Chen L, Bao Y, Li Z, Cui R, Li G and Wang Y: Identification of low miR-105 expression as a novel poor prognostic predictor for human glioma. Int J Clin Exp Med. 8:10855–10864. 2015.PubMed/NCBI

17 

NCBI Resource Coordinators: Database resources of the national center for biotechnology information. Nucleic Acids Res. 44:D7–D19. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:(Database Issue). D991–D995. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Lantuejoul S, Rouquette I, Brambilla E and Travis WD: New WHO classification of lung adenocarcinoma and preneoplasia. Ann Pathol. 36:5–14. 2016.(In French). View Article : Google Scholar : PubMed/NCBI

20 

Edge SB and Compton CC: The American Joint Committee on cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e1792005. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Schaap-Oziemlak AM, Raymakers RA, Bergevoet SM, Gilissen C, Jansen BJ, Adema GJ, Kögler G, le Sage C, Agami R, van der Reijden BA and Jansen JH: MicroRNA hsa-miR-135b regulates mineralization in osteogenic differentiation of human unrestricted somatic stem cells. Stem Cells Dev. 19:877–885. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Zhao B, Zhu Y, Cui K, Gao J, Yu F, Chen L and Li S: Expression and significance of PTEN and miR-92 in hepatocellular carcinoma. Mol Med Rep. 7:1413–1416. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Gao F, Wang T, Zhang Z, Wang R, Guo Y and Liu J: Regulation of activating protein-4-associated metastases of non-small cell lung cancer cells by miR-144. Tumour Biol. Aug 8–2015.(Epub ahead of print).

26 

Qi F, He T, Jia L, Song N, Guo L, Ma X, Wang C, Xu M, Fu Y, Li L and Luo Y: The miR-30 family inhibits pulmonary vascular hyperpermeability in the premetastatic phase by direct targeting of Skp2. Clin Cancer Res. 21:3071–3080. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Hu Z, Chen X, Zhao Y, Tian T, Jin G, Shu Y, Chen Y, Xu L, Zen K, Zhang C and Shen H: Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer. J Clin Oncol. 28:1721–1726. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Liu D, Hu X, Zhou H, Shi G and Wu J: Identification of aberrantly expressed miRNAs in gastric cancer. Gastroenterol Res Pract. 2014:4738172014. View Article : Google Scholar : PubMed/NCBI

29 

Zen K and Zhang CY: Circulating microRNAs: A novel class of biomarkers to diagnose and monitor human cancers. Med Res Rev. 32:326–348. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Shen G, Rong X, Zhao J, Yang X, Li H, Jiang H, Zhou Q, Ji T, Huang S, Zhang J and Jia H: MicroRNA-105 suppresses cell proliferation and inhibits PI3K/AKT signaling in human hepatocellular carcinoma. Carcinogenesis. 35:2748–2755. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Han Y, Jia C, Cong X, Yu F, Cai H, Fang S, Cai L, Yang H, Sun Y, Li D, et al: Increased expression of TGFβR2 is associated with the clinical outcome of non-small cell lung cancer patients treated with chemotherapy. PLoS One. 10:e01346822015. View Article : Google Scholar : PubMed/NCBI

32 

Honeywell DR, Cabrita MA, Zhao H, Dimitroulakos J and Addison CL: miR-105 inhibits prostate tumour growth by suppressing CDK6 levels. PLoS One. 8:e705152013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lu G, Fu D, Jia C, Chai L, Han Y, Liu J, Wu T, Xie R, Chang Z, Yang H, Yang H, et al: Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer. Oncol Lett 14: 7842-7848, 2017.
APA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J. ... Ma, Y. (2017). Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer. Oncology Letters, 14, 7842-7848. https://doi.org/10.3892/ol.2017.7228
MLA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14.6 (2017): 7842-7848.
Chicago
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14, no. 6 (2017): 7842-7848. https://doi.org/10.3892/ol.2017.7228
Copy and paste a formatted citation
x
Spandidos Publications style
Lu G, Fu D, Jia C, Chai L, Han Y, Liu J, Wu T, Xie R, Chang Z, Yang H, Yang H, et al: Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer. Oncol Lett 14: 7842-7848, 2017.
APA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J. ... Ma, Y. (2017). Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer. Oncology Letters, 14, 7842-7848. https://doi.org/10.3892/ol.2017.7228
MLA
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14.6 (2017): 7842-7848.
Chicago
Lu, G., Fu, D., Jia, C., Chai, L., Han, Y., Liu, J., Wu, T., Xie, R., Chang, Z., Yang, H., Luo, P., Lv, Z., Yu, F., Zhong, X., Ma, Y."Reduced miR-105-1 levels are associated with poor survival of patients with non‑small cell lung cancer". Oncology Letters 14, no. 6 (2017): 7842-7848. https://doi.org/10.3892/ol.2017.7228
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