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Article

CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells

  • Authors:
    • Yang Yang
    • Jie Hou
    • Mingliang Shao
    • Wei Zhang
    • Yaling Qi
    • Shengnan E
    • Shuqiu Wang
    • Hongyu Sui
    • Dexin Meng
    • Baixin Wang
    • Mingfu Wang
    • Yang Han
    • Yu Cao
    • Xiaoqing Huang
    • Yue Li
    • Pengxia Zhang
    • Weiqun Wang
  • View Affiliations / Copyright

    Affiliations: Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China, The First Affiliated Hospital, Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China, The Fifth Hospital, Shijiazhuang, Hebei 050021, P.R. China, Hainan Medical College, Haikou, Hainan 571199, P.R. China
  • Pages: 7977-7985
    |
    Published online on: October 20, 2017
       https://doi.org/10.3892/ol.2017.7236
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Abstract

C‑X‑C motif chemokine ligand 5 (CXCL5) is a CXC‑type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was expressed in both hepatoblastoma HepG2 cells and liver stellate LX‑2 cells, and CXCL5's receptor C‑X‑C chemokine receptor type 2 (CXCR2) was expressed in HepG2 cells by reverse transcription‑polymerase chain reaction (RT‑PCR), western blotting and ELISA assays. Cell counting kit‑8, colony formation and Transwell assays revealed that exogenous CXCL5 expression efficiently promoted proliferation, colony formation and migration of HepG2 cells. To explore the autocrine and paracrine roles of CXCL5 in the oncogenic potential of HepG2 cells, HepG2 cells overexpressing CXCL5 and LX‑2 cells overexpressing CXCL5 were successfully constructed by gene transfection. Similarly, overexpression of CXCL5 in HepG2 also enhanced proliferation, colony formation and migration of HepG2 cells. Furthermore, the condition medium of LX‑2 cells overexpressing CXCL5 affected the proliferation and migration of HepG2 cells. RT‑PCR and western blotting assays were also conducted to explore whether overexpression of CXCL5 in HepG2 modulated the expression of genes. The results revealed that overexpression of CXCL5 regulated the expression of several genes, including N‑myc downregulated gene 3,w B‑cell lymphoma‑2 (Bcl‑2), Bcl‑2‑associated X protein, P53, vascular endothelial growth factor, interleukin (IL)‑18, IL‑1β and cystathionine‑γ‑lyase. In conclusion, the present findings indicate that CXCL5/CXCR2 axis contributes to the oncogenic potential of hepatoblastoma via autocrine or paracrine pathways by regulating expression of genes associated with the progression of carcinoma.
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View References

1 

Stocker JT: Hepatoblastoma. Semin Diagn Pathol. 11:136–143. 1994.PubMed/NCBI

2 

Khaderi S, Guiteau J, Cotton RT, O'Mahony C, Rana A and Goss JA: Role of liver transplantation in the management of hepatoblastoma in the pediatric population. World J Transplant. 4:294–298. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Hiyama E: Pediatric hepatoblastoma: Diagnosis and treatment. Transl Pediatr. 3:293–299. 2014.PubMed/NCBI

4 

Kayisli UA, Mahutte NG and Arici A: Uterine chemokines in reproductive physiology and pathology. Am J Reprod Immunol. 47:213–221. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Murdoch C and Finn A: Chemokine receptors and their role in inflammation and infectious diseases. Blood. 95:3032–3043. 2000.PubMed/NCBI

6 

Kollet O, Vagima Y, D'Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, et al: Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors. Leukemia. 27:2006–2015. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Koch AE: Review: Angiogenesis: Implications for rheumatoid arthritis. Arthritis Rheum. 41:951–962. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Selam B, Kayisli UA, Garcia-Velasco JA, Akbas GE and Arici A: Regulation of fas ligand expression by IL-8 in human endometrium. J Clin Endocrinol Metab. 87:3921–3927. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Milliken D, Scotton C, Raju S, Balkwill F and Wilson J: Analysis of chemokines and chemokine receptor expression in ovarian cancer ascites. Clin Cancer Res. 84:1108–1114. 2002.

10 

Arenberg DA, Keane MP, DiGiovine B, Kunkel SL, Morris SB, Xue YY, Burdick MD, Glass MC, Iannettoni MD and Strieter RM: Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer. J Clin Invest. 102:465–472. 1998. View Article : Google Scholar : PubMed/NCBI

11 

Begley LA, MacDonald JW, Day ML and Macoska JA: CXCL12 activates a robust transcriptional response in human prostate epithelial cells. J Biol Chem. 282:26767–26774. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Murakami T, Maki W, Cardones AR, Fang H, Kyi Tun A, Nestle FO and Hwang ST: Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanomacells. Cancer Res. 15:7328–7334. 2002.

13 

Hirbe AC, Morgan EA and Weilbaecher KN: The CXCR4/SDF-1 chemokine axis: A potential therapeutic target for bone metastases? Curr Pharm Des. 16:1284–1290. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Begley LA, Kasina S, Mehra R, Adsule S, Admon AJ, Lonigro RJ, Chinnaiyan AM and Macoska JA: CXCL5 promotes prostate cancer progression. Neoplasia. 10:244–254. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Miyazaki H, Patel V, Wang H, Edmunds RK, Gutkind JS and Yeudall WA: Down-regulation of CXCL5 inhibits squamous carcinogenesis. Cancer Res. 66:4279–4284. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Park JY, Park KH, Bang S, Kim MH, Lee JE, Gang J, Koh SS and Song SY: CXCL5 overexpression is associated with late stage gastric cancer. J Cancer Res Clin Oncol. 133:835–840. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Zhou SL, Dai Z, Zhou ZJ, Wang XY, Yang GH, Wang Z, Huang XW, Fan J and Zhou J: Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma. Hepatology. 56:2242–2254. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Wang W, Li Y, Li Y, Hong A, Wang J, Lin B and Li R: NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth. Int J Cancer. 124:521–530. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Rollins BJ: Inflammatory chemokines in cancer growth and progression. Eur J Cancer. 42:760–767. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Speetjens FM, Kuppen PJ, Sandel MH, Menon AG, Burg D, van de Velde CJ, Tollenaar RA, de Bont HJ and Nagelkerke JF: Disrupted expression of CXCL5 in Colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients. Clin Cancer Res. 14:2276–2284. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Xia J, Xu X, Huang P, He M and Wang X: The potential of CXCL5 as a target for liver cancer - what do we know so far? Expert Opin Ther Targets. 19:141–146. 2015. View Article : Google Scholar : PubMed/NCBI

22 

López-Terrada D, Cheung SW, Finegold MJ and Knowles BB: Hep G2 is a hepatoblastoma-derived cell line. Hum Pathol. 40:1512–1515. 2009. View Article : Google Scholar

23 

Yumnam S, Hong GE, Raha S, Saralamma VV, Lee HJ, Lee WS, Kim EH and Kim GS: Mitochondrial dysfunction and Ca(2+) overload contributes to hesperidin induced paraptosis in hepatoblastoma cells, HepG2. J Cell Physiol. 231:1261–1268. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Nishikawa T, Tanaka Y, Nishikawa M, Ogino Y, Kusamori K, Mizuno N, Mizukami Y, Shimizu K, Konishi S, Takahashi Y and Takakura Y: Optimization of albumin secretion and metabolic activity of cytochrome P450 1A1 of human hepatoblastoma HepG2 cells in multicellular spheroids by controlling spheroid size. Biol Pharm Bull. 40:334–338. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Leibowitz B and Yu J: Mitochondrial signaling in cell death via the Bcl-2 family. Cancer Biol Ther. 9:417–422. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Khodapasand E, Jafarzadeh N, Farrokhi F, Kamalidehghan B and Houshmand M: Is Bax/Bcl-2 ratio considered as a prognostic marker with age and tumor location in colorectal cancer? Iran Biomed J. 19:69–75. 2015.PubMed/NCBI

27 

Zeren T, Inan S, Vatansever HS and Sayhan S: Significance of apoptosis related proteins on malignant transformation of ovarian tumors: A comparison between Bcl-2/Bax ratio and p53 immunoreactiviy. Acta Histochem. 116:1251–1258. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Lee WS, Yi SM, Yun JW, Jung JH, Kim DH, Kim HJ, Chang SH, Kim G, Ryu CH, Shin SC, et al: Polyphenols isolated from allium cepa L. Induces apoptosis by induction of p53 and suppression of Bcl-2 through inhibiting PI3K/Akt signaling pathway in AGS human cancer cells. J Cancer Prev. 19:14–22. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Zhang J, Li F, Liu X, Shen L, Liu J, Su J, Zhang W, Deng Y, Wang L, Liu N, et al: The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter. J Biol Chem. 281:39159–39168. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Zhao W, Tang R, Huang Y, Wang W, Zhou Z, Gu S, Dai J, Ying K, Xie Y and Mao Y: Cloning and expression pattern of the human NDRG3 gene. Biochim Biophys Acta. 1519:134–138. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Tian X, Meng L, Shou C and Dong Z: Coexpression of vascular endothelial growth factor and its receptor KDR on gastric adenocarcinoma MGC803 cell line and stimulation of exogenous VEGF (165) to MGC803 cells. Sci China C Life Sci. 43:88–95. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Wu D, Si W, Wang M, Lv S, Ji A and Li Y: Hydrogen sulfide in cancer: Friend or foe? Nitric Oxide. 50:38–45. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N, Qi J, Wang L, Shi Y, et al: Sp1 is involved inregulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal. 24:1229–1240. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Wang XH, Wang F, You SJ, Cao YJ, Cao LD, Han Q, Liu CF and Hu LF: Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage. Cell Signal. 25:2255–2262. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Fan K, Li N, Qi J, Yin P, Zhao C, Wang L, Li Z and Zha X: Wnt/β-catenin signaling induces the transcription of cystathionine-γ-lyase, a stimulator of tumor in colon cancer. Cell Signal. 26:2801–2808. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Palma G, Barbieri A, Bimonte S, Palla M, Zappavigna S, Caraglia M, Ascierto PA, Ciliberto G and Arra C: Interleukin 18: Friend or foe in cancer. Biochim Biophys Acta. 1836:296–303. 2013.PubMed/NCBI

37 

Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG and Wang TC: Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derivedsuppressor cells in mice. Cancer Cell. 14:408–419. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Hou J, Shao M, Zhang W, Qi Y, E S, Wang S, Sui H, Meng D, Wang B, Wang B, et al: CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells. Oncol Lett 14: 7977-7985, 2017.
APA
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S. ... Wang, W. (2017). CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells. Oncology Letters, 14, 7977-7985. https://doi.org/10.3892/ol.2017.7236
MLA
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S., Wang, S., Sui, H., Meng, D., Wang, B., Wang, M., Han, Y., Cao, Y., Huang, X., Li, Y., Zhang, P., Wang, W."CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells". Oncology Letters 14.6 (2017): 7977-7985.
Chicago
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S., Wang, S., Sui, H., Meng, D., Wang, B., Wang, M., Han, Y., Cao, Y., Huang, X., Li, Y., Zhang, P., Wang, W."CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells". Oncology Letters 14, no. 6 (2017): 7977-7985. https://doi.org/10.3892/ol.2017.7236
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Hou J, Shao M, Zhang W, Qi Y, E S, Wang S, Sui H, Meng D, Wang B, Wang B, et al: CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells. Oncol Lett 14: 7977-7985, 2017.
APA
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S. ... Wang, W. (2017). CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells. Oncology Letters, 14, 7977-7985. https://doi.org/10.3892/ol.2017.7236
MLA
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S., Wang, S., Sui, H., Meng, D., Wang, B., Wang, M., Han, Y., Cao, Y., Huang, X., Li, Y., Zhang, P., Wang, W."CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells". Oncology Letters 14.6 (2017): 7977-7985.
Chicago
Yang, Y., Hou, J., Shao, M., Zhang, W., Qi, Y., E, S., Wang, S., Sui, H., Meng, D., Wang, B., Wang, M., Han, Y., Cao, Y., Huang, X., Li, Y., Zhang, P., Wang, W."CXCL5 as an autocrine or paracrine cytokine is associated with proliferation and migration of hepatoblastoma HepG2 cells". Oncology Letters 14, no. 6 (2017): 7977-7985. https://doi.org/10.3892/ol.2017.7236
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