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Review Open Access

Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)

  • Authors:
    • Christoph Spiekermann
    • Meike Kuhlencord
    • Sebastian Huss
    • Claudia Rudack
    • Daniel Weiss
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Münster, D‑48149 Münster, Germany, Institute of Immunology, University Hospital Münster, D‑48149 Münster, Germany, Institute of Pathology, University Hospital Münster, D‑48149 Münster, Germany
    Copyright: © Spiekermann et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 7643-7652
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    Published online on: October 20, 2017
       https://doi.org/10.3892/ol.2017.7247
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Abstract

Sarcoidosis, a chronic, inflammatory disease that affects various different organs, is characterized by noncaseating epitheloid granulomas. This systemic inflammatory process is associated with an increased risk of cancer. Several cases of sarcoidosis that mimic metastatic tumor progression in radiological findings have been reported so far. However, there are also cases that have presented a coexistence of sarcoidosis and metastasis, which have caused a diagnostic and therapeutic dilemma. Due to inadequate current therapies, a reliable differentiation between benign and malignant lesions is crucial. This review focuses on the residual risk of the coexistence of metastases within radiological suspicious lesions in patients with a history of solid tumors and sarcoidosis, as well as immunological findings, in order to explain the potential associations. Sarcoidosis has the potential to promote metastasis as it includes tumor‑promoting and immune‑regulating cell subsets. Notably, myeloid derived suppressor cells may serve a pivotal role in metastatic progression in patients with sarcoidosis. In addition, the present review also evaluates the potential novel diagnostic approaches, which may be able to differentiate between metastatic lesions and sarcoidosis. The risk of coexistent metastasis in sarcoidosis lesions must be considered by clinical practitioners, and a multidisciplinary approach may be required to avoid misdiagnosis and the subsequent unnecessary surgery or insufficient treatments.
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Copy and paste a formatted citation
Spandidos Publications style
Spiekermann C, Kuhlencord M, Huss S, Rudack C and Weiss D: Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review). Oncol Lett 14: 7643-7652, 2017.
APA
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., & Weiss, D. (2017). Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review). Oncology Letters, 14, 7643-7652. https://doi.org/10.3892/ol.2017.7247
MLA
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., Weiss, D."Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)". Oncology Letters 14.6 (2017): 7643-7652.
Chicago
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., Weiss, D."Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)". Oncology Letters 14, no. 6 (2017): 7643-7652. https://doi.org/10.3892/ol.2017.7247
Copy and paste a formatted citation
x
Spandidos Publications style
Spiekermann C, Kuhlencord M, Huss S, Rudack C and Weiss D: Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review). Oncol Lett 14: 7643-7652, 2017.
APA
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., & Weiss, D. (2017). Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review). Oncology Letters, 14, 7643-7652. https://doi.org/10.3892/ol.2017.7247
MLA
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., Weiss, D."Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)". Oncology Letters 14.6 (2017): 7643-7652.
Chicago
Spiekermann, C., Kuhlencord, M., Huss, S., Rudack, C., Weiss, D."Coexistence of sarcoidosis and metastatic lesions: A diagnostic and therapeutic dilemma (Review)". Oncology Letters 14, no. 6 (2017): 7643-7652. https://doi.org/10.3892/ol.2017.7247
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