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Article

Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma

  • Authors:
    • Kunio Iura
    • Kenichi Kohashi
    • Nobuko Yasutake
    • Takeaki Ishii
    • Akira Maekawa
    • Hirofumi Bekki
    • Hiroshi Otsuka
    • Yuichi Yamada
    • Hidetaka Yamamoto
    • Yoshihiro Ohishi
    • Yoshihiro Matsumoto
    • Yukihide Iwamoto
    • Yoshinao Oda
  • View Affiliations / Copyright

    Affiliations: Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812‑8581, Japan, Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka 812‑8581, Japan
  • Pages: 441-446
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/ol.2017.7274
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Abstract

Leiomyosarcomas account for ~24% of all adult sarcomas, and develop predominantly either in the uterus [uterine leiomyosarcoma (ULMS)] or in deep soft tissue or the retroperitoneum [non‑uterine leiomyosarcoma (NULMS)]. Leiomyosarcomas are relatively chemoresistant tumors, and the prognosis of patients with leiomyosarcomas is poor. Cancer‑testis (CT) antigens are considered promising immunotherapeutic targets because of their restricted expression in normal tissue, except in the testis. Little is known about the expression of CT antigens in leiomyosarcomas. In the present study, the protein expression of the CT antigens MAGE family member A (MAGEA)1, MAGEA3, MAGEA4, G antigen 7 (GAGE7) and cancer/testis antigen 1 (NY‑ESO‑1) in ULMS and NULMS were investigated using immunohistochemistry (IHC), and their expression profiles compared. In ULMS and NULMS, positive expression was observed in 11/32 (31%) and 1/31 (3%; MAGEA1), 15/32 (47%) and 5/31 (16%; MAGEA3), 11/32 (34%) and 3/31 (10%; MAGEA4), 23/32 (72%) and 11/31 (35%; GAGE7) and 3/32 (9%) and 0/31 (0%; NY‑ESO‑1), respectively. The ULMSs demonstrated significantly higher positive expression of MAGEA1 (P=0.0034), MAGEA3 (P=0.0141), MAGEA4 (P=0.0319) and GAGE7 (P=0.0054) compared with the NULMSs. The ULMSs also had significantly higher IHC scores for MAGEA1 (P=0.0023), MAGEA3 (P=0.0474), MAGEA4 (P=0.011), GAGE7 (P=0.0319) and NY‑ESO‑1 (P=0.0437). The results of the present study support the potential utility of MAGEA1, MAGEA3, MAGEA4 and GAGE7 in ULMS and GAGE7 in NULMS as immunotherapeutic targets.
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Copy and paste a formatted citation
Spandidos Publications style
Iura K, Kohashi K, Yasutake N, Ishii T, Maekawa A, Bekki H, Otsuka H, Yamada Y, Yamamoto H, Ohishi Y, Ohishi Y, et al: Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma. Oncol Lett 15: 441-446, 2018.
APA
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H. ... Oda, Y. (2018). Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma. Oncology Letters, 15, 441-446. https://doi.org/10.3892/ol.2017.7274
MLA
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H., Otsuka, H., Yamada, Y., Yamamoto, H., Ohishi, Y., Matsumoto, Y., Iwamoto, Y., Oda, Y."Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma". Oncology Letters 15.1 (2018): 441-446.
Chicago
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H., Otsuka, H., Yamada, Y., Yamamoto, H., Ohishi, Y., Matsumoto, Y., Iwamoto, Y., Oda, Y."Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma". Oncology Letters 15, no. 1 (2018): 441-446. https://doi.org/10.3892/ol.2017.7274
Copy and paste a formatted citation
x
Spandidos Publications style
Iura K, Kohashi K, Yasutake N, Ishii T, Maekawa A, Bekki H, Otsuka H, Yamada Y, Yamamoto H, Ohishi Y, Ohishi Y, et al: Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma. Oncol Lett 15: 441-446, 2018.
APA
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H. ... Oda, Y. (2018). Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma. Oncology Letters, 15, 441-446. https://doi.org/10.3892/ol.2017.7274
MLA
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H., Otsuka, H., Yamada, Y., Yamamoto, H., Ohishi, Y., Matsumoto, Y., Iwamoto, Y., Oda, Y."Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma". Oncology Letters 15.1 (2018): 441-446.
Chicago
Iura, K., Kohashi, K., Yasutake, N., Ishii, T., Maekawa, A., Bekki, H., Otsuka, H., Yamada, Y., Yamamoto, H., Ohishi, Y., Matsumoto, Y., Iwamoto, Y., Oda, Y."Cancer‑testis antigens are predominantly expressed in uterine leiomyosarcoma compared with non‑uterine leiomyosarcoma". Oncology Letters 15, no. 1 (2018): 441-446. https://doi.org/10.3892/ol.2017.7274
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