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Article Open Access

SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion

  • Authors:
    • Yang Li
    • Xingli Dong
    • Jinquan Cai
    • Shi Yin
    • Ying Sun
    • Dongbo Yang
    • Chuanlu Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China, Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 285-291
    |
    Published online on: October 26, 2017
       https://doi.org/10.3892/ol.2017.7275
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Abstract

Glioblastoma (GBM) is a highly invasive and malignant brain tumor. Currently, it remains unclear whether Glioblastoma stem‑like cells (GSCs) contribute to the invasive phenotype of GBM. Invasion is a complex process involving interactions between tumor cells with the extracellular matrix (ECM), in addition to normal cells. The present study aimed to identify the regulators of GSCs invasion in the GBM tumor microenvironment. An integrative analysis was conducted to identify genes that are important for GSC invasion and are specifically upregulated in astroglia/microglia co‑cultured GSCs. Of the identified genes, serpin peptidase inhibitor clade A member 3 (SERPINA3) was observed to be abnormally overexpressed in astroglia/microglia co‑cultured GSCs. To further investigate the role of SERPINA3 in glioma pathogenesis and prognosis, a tissue microarray analysis was conducted to evaluate the expression of SERPINA3 and its association to clinicopathological factors and patient survival. The data indicated that upregulation of SERPINA3 was significantly associated with glioma progression and poor patient survival. Furthermore, it was demonstrated that the upregulation of SERPINA3 in glioma may contribute to the invasive behavior of GBM cells by remodeling of the ECM. Overall, the findings of the present study may be useful in future prognosis of GBM patients, suggesting that SERPINA is a potential therapeutic target, and may lead to further understanding of GBM and cancer progression as a whole.
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1 

Meyer MA: Malignant gliomas in adults. N Engl J Med. 359:18502008. View Article : Google Scholar : PubMed/NCBI

2 

Chen D, Song M, Mohamad O and Yu SP: Inhibition of Na+/K+-ATPase induces hybrid cell death and enhanced sensitivity to chemotherapy in human glioblastoma cells. BMC Cancer. 14:7162014. View Article : Google Scholar : PubMed/NCBI

3 

Binda E, Visioli A, Giani F, Trivieri N, Palumbo O, Restelli S, Dezi F, Mazza T, Fusilli C, Legnani F, et al: Wnt5a drives an invasive phenotype in human glioblastoma stem-like cells. Cancer Res. 77:996–1007. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD and Rich JN: Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 444:756–760. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Eramo A, Ricci-Vitiani L, Zeuner A, Pallini R, Lotti F, Sette G, Pilozzi E, Larocca LM, Peschle C and De Maria R: Chemotherapy resistance of glioblastoma stem cells. Cell Death Differ. 13:1238–1241. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Rath BH, Fair JM, Jamal M, Camphausen K and Tofilon PJ: Astrocytes enhance the invasion potential of glioblastoma stem-like cells. PLoS One. 8:e547522013. View Article : Google Scholar : PubMed/NCBI

7 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Rath BH, Wahba A, Camphausen K and Tofilon PJ: Coculture with astrocytes reduces the radiosensitivity of glioblastoma stem-like cells and identifies additional targets for radiosensitization. Cancer Med. 4:1705–1716. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Kalsheker NA: Alpha 1-antichymotrypsin. Int J Biochem Cell Biol. 28:961–964. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Baker C, Belbin O, Kalsheker N and Morgan K: SERPINA3 (aka alpha-1-antichymotrypsin). Front Biosci. 12:2821–2835. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Sun YX, Wright HT and Janciauskiene S: Glioma cell activation by Alzheimer's peptide Abeta1-42, alpha1-antichymotrypsin, and their mixture. Cell Mol Life Sci. 59:1734–1743. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Bodmer JL and Schnebli HP: Plasma proteinase inhibitors. Schweiz Med Wochenschr. 114:1359–1363. 1984.PubMed/NCBI

13 

Sun YX, Wright HT and Janciauskiene S: Alpha1-antichymotrypsin/Alzheimer's peptide Abeta(1–42) complex perturbs lipid metabolism and activates transcription factors PPARgamma and NFkappaB in human neuroblastoma (Kelly) cells. J Neurosci Res. 67:511–522. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Karashima S, Kataoka H, Itoh H, Maruyama R and Koono M: Prognostic significance of alpha-1-antitrypsin in early stage of colorectal carcinomas. Int J Cancer. 45:244–250. 1990. View Article : Google Scholar : PubMed/NCBI

15 

Hurlimann J and van Melle G: Prognostic value of serum proteins synthesized by breast carcinoma cells. Am J Clin Pathol. 95:835–843. 1991. View Article : Google Scholar : PubMed/NCBI

16 

Lein M, Stephan C, Jung K, Schnorr D and Loening SA: Molecular forms of prostate-specific antigen and human kallikrein 2 as possible indicators in prostatic carcinoma diagnosis. Urologe A. 39:313–323. 2000.(In German). View Article : Google Scholar : PubMed/NCBI

17 

Higashiyama M, Doi O, Yokouchi H, Kodama K, Nakamori S and Tateishi R: Alpha-1-antichymotrypsin expression in lung adenocarcinoma and its possible association with tumor progression. Cancer. 76:1368–1376. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Zelvyte I, Wallmark A, Piitulainen E, Westin U and Janciauskiene S: Increased plasma levels of serine proteinase inhibitors in lung cancer patients. Anticancer Res. 24:241–247. 2004.PubMed/NCBI

19 

Tahara E, Ito H, Taniyama K, Yokozaki H and Hata J: Alpha 1-antitrypsin, alpha 1-antichymotrypsin, and alpha 2-macroglobulin in human gastric carcinomas: A retrospective immunohistochemical study. Hum Pathol. 15:957–964. 1984. View Article : Google Scholar : PubMed/NCBI

20 

Zhou SM, Cheng L, Guo SJ, Wang Y, Czajkowsky DM, Gao H, Hu XF and Tao SC: Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple-negative breast cancer. Breast Cancer Res. 17:362015. View Article : Google Scholar : PubMed/NCBI

21 

Sjoestroem C, Khosravi S, Cheng Y, Safaee Ardekani G, Martinka M and Li G: DLC1 expression is reduced in human cutaneous melanoma and correlates with patient survival. Mod Pathol. 27:1203–1211. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Remmele W and Stegner HE: Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER-ICA) in breast cancer tissue. Pathologe. 8:138–140. 1987.(In German). PubMed/NCBI

23 

Abd Hamid UM, Royle L, Saldova R, Radcliffe CM, Harvey DJ, Storr SJ, Pardo M, Antrobus R, Chapman CJ, Zitzmann N, et al: A strategy to reveal potential glycan markers from serum glycoproteins associated with breast cancer progression. Glycobiology. 18:1105–1118. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Friedl P and Alexander S: Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell. 147:992–1009. 2011. View Article : Google Scholar : PubMed/NCBI

25 

The tumor microenvironment mediates GBM resistance to CSF1R blockade. Cancer Discov. 6:6902016. View Article : Google Scholar

26 

Sarkar S, Döring A, Zemp FJ, Silva C, Lun X, Wang X, Kelly J, Hader W, Hamilton M, Mercier P, et al: Therapeutic activation of macrophages and microglia to suppress brain tumor-initiating cells. Nat Neurosci. 17:46–55. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Sofroniew MV and Vinters HV: Astrocytes: Biology and pathology. Acta Neuropathol. 119:7–35. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Charles NA, Holland EC, Gilbertson R, Glass R and Kettenmann H: The brain tumor microenvironment. Glia. 60:502–514. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Danø K, Andreasen PA, Grøndahl-Hansen J, Kristensen P, Nielsen LS and Skriver L: Plasminogen activators, tissue degradation, and cancer. Adv Cancer Res. 44:139–266. 1985. View Article : Google Scholar : PubMed/NCBI

30 

Mignatti P and Rifkin DB: Biology and biochemistry of proteinases in tumor invasion. Physiol Rev. 73:161–195. 1993.PubMed/NCBI

31 

Dodwell DJ: Proteinase inhibitors in malignancy: Therapeutic promise or another white elephant? J R Soc Med. 86:573–576. 1993.PubMed/NCBI

32 

Liotta LA and Kohn EC: The microenvironment of the tumour-host interface. Nature. 411:375–379. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Beatty K, Bieth J and Travis J: Kinetics of association of serine proteinases with native and oxidized alpha-1-proteinase inhibitor and alpha-1-antichymotrypsin. J Biol Chem. 255:3931–3934. 1980.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Dong X, Cai J, Yin S, Sun Y, Yang D and Jiang C: SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion. Oncol Lett 15: 285-291, 2018.
APA
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., & Jiang, C. (2018). SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion. Oncology Letters, 15, 285-291. https://doi.org/10.3892/ol.2017.7275
MLA
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., Jiang, C."SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion". Oncology Letters 15.1 (2018): 285-291.
Chicago
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., Jiang, C."SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion". Oncology Letters 15, no. 1 (2018): 285-291. https://doi.org/10.3892/ol.2017.7275
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Dong X, Cai J, Yin S, Sun Y, Yang D and Jiang C: SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion. Oncol Lett 15: 285-291, 2018.
APA
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., & Jiang, C. (2018). SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion. Oncology Letters, 15, 285-291. https://doi.org/10.3892/ol.2017.7275
MLA
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., Jiang, C."SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion". Oncology Letters 15.1 (2018): 285-291.
Chicago
Li, Y., Dong, X., Cai, J., Yin, S., Sun, Y., Yang, D., Jiang, C."SERPINA3 induced by astroglia/microglia co‑culture facilitates glioblastoma stem‑like cell invasion". Oncology Letters 15, no. 1 (2018): 285-291. https://doi.org/10.3892/ol.2017.7275
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