CDKN1A‑interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma

Zhou,Xiaojun; Liu,Qiang; Wada,Youichiro; Liao,Lin; Liu,Ju

doi:10.3892/ol.2017.7282

CDKN1A‑interacting zinc finger protein 1 is a novel biomarker for lung squamous cell carcinoma

Authors:
- Xiaojun Zhou
- Qiang Liu
- Youichiro Wada
- Lin Liao
- Ju Liu
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Affiliations: Department of Endocrinology, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China, The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153‑8904, Japan
Published online on: October 26, 2017 https://doi.org/10.3892/ol.2017.7282
Pages: 183-188
Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CDKN1A‑interacting zinc finger protein 1 (CIZ1), a nuclear protein that participates in DNA replication, is involved in the pathogenesis of several types of cancer. However, the role of CIZ1 in lung squamous cell carcinoma (LSCC) is not fully understood. In the present study, the expression of CIZ1 in tissue microarrays and surgical samples of human LSCCs was examined. CIZ1 expression was found to be significantly increased in LSCC tissues compared with adjacent tissues or normal controls, whereas expression of a CIZ1‑interacting protein, p21Cip1/Waf1, was decreased. CIZ1 staining intensity and CIZ1‑positive vascular invasion were positively correlated with at least two categories of the Tumor‑Node‑Metastasis (TNM) staging system (T stage, N stage or TNM stage). It was also observed that CIZ1 was specifically expressed in the vascular cells of LSCC tissues. These results indicate that overexpression of CIZ1 may contribute to the growth and angiogenesis of LSCC, thus CIZ1 could represent a biomarker for diagnosis and a target for therapeutic intervention.

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